Department of Microbiology (2022-24)

1: Zhang X, Lam SJ, Ip JD, Fong CH, Chu AW, Chan WM, Lai YS, Tsoi HW, Chan BP, Chen LL, Meng X, Yuan S, Zhao H, Cheng VC, Yuen JKY, Yuen KY, Zhou J, To KK. Characterizing fitness and immune escape of SARS-CoV-2 EG.5 sublineage using elderly serum and nasal organoid. iScience. 2024 Apr 9;27(5):109706. doi: 10.1016/j.isci.2024.109706. PMID: 38660398; PMCID: PMC11039328.

2: Chan JF, Yuan S, Chu H, Sridhar S, Yuen KY. COVID-19 drug discovery and treatment options. Nat Rev Microbiol. 2024 Apr 15. doi: 10.1038/s41579-024-01036-y. Epub ahead of print. PMID: 38622352.

3: Zhou Y, Cheng T, Tang K, Li H, Luo C, Yu F, Xiao F, Jin L, Hung IF, Lu L, Yuen KY, Chan JF, Yuan S, Sun H. Integration of metalloproteome and immunoproteome reveals a tight link of iron-related proteins with COVID-19 pathogenesis and immunity. Clin Immunol. 2024 Apr 2;263:110205. doi: 10.1016/j.clim.2024.110205. Epub ahead of print. PMID: 38575044.

4: Yip CC, Poon JH, Leung KH, Chan WM, Ip JD, Chu AW, Cheng VC, Yuen KY, To KK. Development and Evaluation of an In-House Real-Time RT-PCR Targeting nsp10 Gene for SARS-CoV-2 Detection. Int J Mol Sci. 2024 Mar 21;25(6):3552. doi: 10.3390/ijms25063552. PMID: 38542524; PMCID: PMC10970969.

5: Xing FF, Chiu KH, Deng CW, Ye HY, Sun LL, Su YX, Cai HJ, Lo SK, Rong L, Chen JL, Cheng VC, Lung DC, Sridhar S, Chan JF, Hung IF, Yuen KY. Post-COVID-19 Pandemic Rebound of Macrolide-Resistant <i>Mycoplasma pneumoniae</i> Infection: A Descriptive Study. Antibiotics (Basel). 2024 Mar 15;13(3):262. doi: 10.3390/antibiotics13030262. PMID: 38534697; PMCID: PMC10967482.

6: Hu B, Chan JF, Liu Y, Liu H, Chen YX, Shuai H, Hu YF, Hartnoll M, Chen L, Xia Y, Hu JC, Yuen TT, Yoon C, Hou Y, Huang X, Chai Y, Zhu T, Shi J, Wang Y, He Y, Cai JP, Zhou J, Yuan S, Zhang J, Huang JD, Yuen KY, To KK, Zhang BZ, Chu H. Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA.2/5 subvariants in the upper and lower respiratory tract. EBioMedicine. 2024 Jan;99:104916. doi: 10.1016/j.ebiom.2023.104916. Epub 2023 Dec 14. PMID: 38101297; PMCID: PMC10733096.

7: Chan TT-Y, Chow FW-N, Fung J, Cheng FK-K, Lo GC-S, Tsang C-C, Luk HK-H, Wong AC-P, He Z, Aw-Yong KL, Liu X, Yuen K-Y, Woo PC-Y, Lau SK-P. A sensitive and simple RT-LAMP assay for sarbecovirus screening in bats. Microbiol Spectr. 2023 Dec 12;11(6):e0259123. doi: 10.1128/spectrum.02591-23. Epub 2023 Nov 16. PMID: 37971222; PMCID: PMC10715088.

8: Tsoi JYH, Cai J, Situ J, Lam WJ, Shun EHK, Leung JKY, Chen LL, Chan BPC, Yeung ML, Li X, Chan KH, Wong JSC, Kwan MYW, To KKW, Yuen KY, Sridhar S. Autoantibodies against angiotensin-converting enzyme 2 (ACE2) after COVID-19 infection or vaccination. J Med Virol. 2023 Dec;95(12):e29313. doi: 10.1002/jmv.29313. PMID: 38100626.

9: Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z. SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters<sup>1</sup>. Emerg Microbes Infect. 2023 Dec;12(2):2245921. doi: 10.1080/22221751.2023.2245921. PMID: 37542391; PMCID: PMC10444022.

10: Chiu KH, Sridhar S, Yuen KY. Preparation for the next pandemic: challenges in strengthening surveillance. Emerg Microbes Infect. 2023 Dec;12(2):2240441. doi: 10.1080/22221751.2023.2240441. PMID: 37474466; PMCID: PMC10478602.

11: Li C, Song W, Chan JF, Chen Y, Liu F, Ye Z, Lam AH, Cai J, Lee AC, Wong BH, Chu H, Lung DC, Sridhar S, Chen H, Zhang AJ, Yuen KY. Intranasal infection by SARS-CoV-2 Omicron variants can induce inflammatory brain damage in newly weaned hamsters. Emerg Microbes Infect. 2023 Dec;12(1):2207678. doi: 10.1080/22221751.2023.2207678. PMID: 37122119; PMCID: PMC10262819.

12: Chiu KH, Yip CC, Poon RW, Leung KH, Li X, Hung IF, To KK, Cheng VC, Yuen KY. Correlations of Myeloperoxidase (MPO), Adenosine deaminase (ADA), C-C motif chemokine 22 (CCL22), Tumour necrosis factor alpha (TNFα) and Interleukin-6 (IL-6) mRNA expression in the nasopharyngeal specimens with the diagnosis and severity of SARS-CoV-2 infections. Emerg Microbes Infect. 2023 Dec;12(1):2157338. doi: 10.1080/22221751.2022.2157338. PMID: 36482706; PMCID: PMC9809351.

13: Luo M, Zhou B, Reddem ER, Tang B, Chen B, Zhou R, Liu H, Liu L, Katsamba PS, Au KK, Man HO, To KK, Yuen KY, Shapiro L, Dang S, Ho DD, Chen Z. Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2. Emerg Microbes Infect. 2023 Dec;12(1):2146538. doi: 10.1080/22221751.2022.2146538. PMID: 36354024; PMCID: PMC9817130.

14: Yuen CK, Wong WM, Mak LF, Lam JY, Cheung LY, Cheung DT, Ng YY, Lee AC, Zhong N, Yuen KY, Kok KH. An interferon-integrated mucosal vaccine provides pan- sarbecovirus protection in small animal models. Nat Commun. 2023 Oct 24;14(1):6762. doi: 10.1038/s41467-023-42349-5. PMID: 37875475; PMCID: PMC10598001.

15: Liu L, Casner RG, Guo Y, Wang Q, Iketani S, Chan JF, Yu J, Dadonaite B, Nair MS, Mohri H, Reddem ER, Yuan S, Poon VK, Chan CC, Yuen KY, Sheng Z, Huang Y, Bloom JD, Shapiro L, Ho DD. Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking. Immunity. 2023 Oct 10;56(10):2442-2455.e8. doi: 10.1016/j.immuni.2023.09.003. Epub 2023 Sep 29. PMID: 37776849; PMCID: PMC10588992.

16: Lam JY, Wong WM, Yuen CK, Ng YY, San CH, Yuen KY, Kok KH. An RNA-Scaffold Protein Subunit Vaccine for Nasal Immunization. Vaccines (Basel). 2023 Sep 29;11(10):1550. doi: 10.3390/vaccines11101550. PMID: 37896953; PMCID: PMC10610892.

17: Shuai H, Chan JF, Hu B, Chai Y, Yoon C, Liu H, Liu Y, Shi J, Zhu T, Hu JC, Hu YF, Hou Y, Huang X, Yuen TT, Wang Y, Zhang J, Xia Y, Chen LL, Cai JP, Zhang AJ, Yuan S, Zhou J, Zhang BZ, Huang JD, Yuen KY, To KK, Chu H. The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5. EBioMedicine. 2023 Sep;95:104753. doi: 10.1016/j.ebiom.2023.104753. Epub 2023 Aug 12. PMID: 37579626; PMCID: PMC10448076.

18: Liu J, Mao F, Chen J, Lu S, Qi Y, Sun Y, Fang L, Yeung ML, Liu C, Yu G, Li G, Liu X, Yao Y, Huang P, Hao D, Liu Z, Ding Y, Liu H, Yang F, Chen P, Sa R, Sheng Y, Tian X, Peng R, Li X, Luo J, Cheng Y, Zheng Y, Lin Y, Song R, Jin R, Huang B, Choe H, Farzan M, Yuen KY, Tan W, Peng X, Sui J, Li W. An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants. Nat Commun. 2023 Aug 25;14(1):5191. doi: 10.1038/s41467-023-40933-3. PMID: 37626079; PMCID: PMC10457309.

19: Wen K, Cai JP, Fan X, Zhang X, Luo C, Tang KM, Shuai H, Chen LL, Zhang RR, Situ J, Tsoi HW, Wang K, Chan JF, Yuan S, Yuen KY, Zhou H, To KK. Broad-spectrum humanized monoclonal neutralizing antibody against SARS-CoV-2 variants, including the Omicron variant. Front Cell Infect Microbiol. 2023 Aug 14;13:1213806. doi: 10.3389/fcimb.2023.1213806. PMID: 37645378; PMCID: PMC10461085.

20: Hu YF, Yuen TT, Gong HR, Hu B, Hu JC, Lin XS, Rong L, Zhou CL, Chen LL, Wang X, Lei C, Yau T, Hung IF, To KK, Yuen KY, Zhang BZ, Chu H, Huang JD. Rational design of a booster vaccine against COVID-19 based on antigenic distance. Cell Host Microbe. 2023 Aug 9;31(8):1301-1316.e8. doi: 10.1016/j.chom.2023.07.004. Epub 2023 Jul 31. PMID: 37527659.

21: Wong SC, Chan VW, Yuen LL, AuYeung CH, Leung JO, Li CK, Kwok MO, So SY, Chen JH, Tam AR, Hung IF, To KK, Lo JY, Yuen KY, Cheng VC. Air dispersal of severe acute respiratory coronavirus virus 2 (SARS-CoV-2): Implications for hospital infection control during the fifth wave of coronavirus disease 2019 (COVID-19) due to the SARS-CoV-2 omicron variant in Hong Kong. Infect Control Hosp Epidemiol. 2023 Aug;44(8):1321-1324. doi: 10.1017/ice.2022.258. Epub 2022 Oct 24. PMID: 36278515.

22: Chung TW, Zhang H, Wong FK, Sridhar S, Lee TM, Leung GK, Chan KH, Lau KK, Tam AR, Ho DT, Cheng VC, Yuen KY, Hung IF, Mak HK. A Pilot Study of Short-Course Oral Vitamin A and Aerosolised Diffuser Olfactory Training for the Treatment of Smell Loss in Long COVID. Brain Sci. 2023 Jun 30;13(7):1014. doi: 10.3390/brainsci13071014. PMID: 37508945; PMCID: PMC10377650.

23: Wong SC, Chau PH, So SY, Chiu KH, Yuen LL, AuYeung CH, Lam GK, Chan VW, Chen JH, Chen H, Li X, Ho PL, Chan SS, Yuen KY, Cheng VC. Epidemiology of multidrug- resistant organisms before and during COVID-19 in Hong Kong. Infect Prev Pract. 2023 Jun;5(2):100286. doi: 10.1016/j.infpip.2023.100286. Epub 2023 May 8. PMID: 37223243; PMCID: PMC10165868.

24: Wong SC, Chan VW, AuYeung CH, Chen JH, Yip CC, So SY, Li X, Lung DC, Tsang AM, To KK, Yuen KY, Cheng VC. Air dispersal of respiratory viruses other than severe acute respiratory coronavirus virus 2 (SARS-CoV-2) and the implication on hospital infection control. Infect Control Hosp Epidemiol. 2023 May;44(5):768-773. doi: 10.1017/ice.2022.186. Epub 2022 Jul 11. PMID: 35811422; PMCID: PMC9304945.

25: Li C, Huang J, Yu Y, Wan Z, Chiu MC, Liu X, Zhang S, Cai JP, Chu H, Li G, Chan JF, To KK, Yang Z, Jiang S, Yuen KY, Clevers H, Zhou J. Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2300376120. doi: 10.1073/pnas.2300376120. Epub 2023 Apr 17. PMID: 37068258; PMCID: PMC10151566.

26: Deng S, Liu Y, Tam RC, Chen P, Zhang AJ, Mok BW, Long T, Kukic A, Zhou R, Xu H, Song W, Chan JF, To KK, Chen Z, Yuen KY, Wang P, Chen H. An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters. Nat Commun. 2023 Apr 12;14(1):2081. doi: 10.1038/s41467-023-37697-1. PMID: 37045873; PMCID: PMC10092940.

27: Zhang R, Chan KH, Wang P, Zhou R, Yau HK, Wong CK, Au MW, Tam AR, Ng CT, Lou MK, Liu N, Huang H, Deng S, Tam RC, Liu Y, Long T, Tsoi HW, Ng MKW, Cai JP, To KK, Yuen MF, Chen Z, Chen H, Yuen KY, Hung IF. A Phase 1, Randomized, Double- Blinded, Placebo-Controlled and Dose-Escalation Study to Evaluate the Safety and Immunogenicity of the Intranasal DelNS1-nCoV-RBD LAIV for COVID-19 in Healthy Adults. Vaccines (Basel). 2023 Mar 24;11(4):723. doi: 10.3390/vaccines11040723. PMID: 37112634; PMCID: PMC10143096.

28: Cai JP, Luo C, Wang K, Cao H, Chen LL, Zhang X, Han Y, Yin F, Zhang AJ, Chu H, Yuan S, Kok KH, To KK, Chen H, Chen Z, Jin DY, Yuen KY, Chan JF. Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice. Viruses. 2023 Mar 6;15(3):687. doi: 10.3390/v15030687. PMID: 36992395; PMCID: PMC10052291.

29: Chen Y, Song W, Li C, Wang J, Liu F, Ye Z, Ren P, Tong Y, Li J, Ou Z, Lee AC, Cai JP, Wong BH, Chan JF, Yuen KY, Zhang AJ, Chu H. COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses. EBioMedicine. 2023 Mar;89:104485. doi: 10.1016/j.ebiom.2023.104485. Epub 2023 Feb 27. PMID: 36857860; PMCID: PMC9970285.

30: Cable J, Denison MR, Kielian M, Jackson WT, Bartenschlager R, Ahola T, Mukhopadhyay S, Fremont DH, Kuhn RJ, Shannon A, Frazier MN, Yuen KY, Coyne CB, Wolthers KC, Ming GL, Guenther CS, Moshiri J, Best SM, Schoggins JW, Jurado KA, Ebel GD, Schäfer A, Ng LFP, Kikkert M, Sette A, Harris E, Wing PAC, Eggenberger J, Krishnamurthy SR, Mah MG, Meganck RM, Chung D, Maurer-Stroh S, Andino R, Korber B, Perlman S, Shi PY, Bárcena M, Aicher SM, Vu MN, Kenney DJ, Lindenbach BD, Nishida Y, Rénia L, Williams EP. Positive-strand RNA viruses-a Keystone Symposia report. Ann N Y Acad Sci. 2023 Mar;1521(1):46-66. doi: 10.1111/nyas.14957. Epub 2023 Jan 25. PMID: 36697369; PMCID: PMC10347887.

31: Zhou R, Liu N, Li X, Peng Q, Yiu CK, Huang H, Yang D, Du Z, Kwok HY, Au KK, Cai JP, Fan-Ngai Hung I, Kai-Wang To K, Xu X, Yuen KY, Chen Z. Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron BA.2: a population-based study in Hong Kong. Lancet Reg Health West Pac. 2023 Mar;32:100660. doi: 10.1016/j.lanwpc.2022.100660. Epub 2022 Dec 23. PMID: 36591327; PMCID: PMC9786166.

32: Zhang X, Chen LL, Ip JD, Chan WM, Hung IF, Yuen KY, Li X, To KK. Omicron sublineage recombinant XBB evades neutralising antibodies in recipients of BNT162b2 or CoronaVac vaccines. Lancet Microbe. 2023 Mar;4(3):e131. doi: 10.1016/S2666-5247(22)00335-4. Epub 2022 Dec 6. PMID: 36493789; PMCID: PMC9725777.

33: Wong SC, Chan VW, Yuen LL, AuYeung CH, Leung JO, Li CK, Kwok MO, So SY, Chen JH, Chiu KH, Tam AR, Hung IF, Kai-Wang To K, Lo JY, Yuen KY, Cheng VC. Infection of healthcare workers despite a high vaccination rate during the fifth wave of COVID-19 due to Omicron variant in Hong Kong. Infect Prev Pract. 2023 Mar;5(1):100261. doi: 10.1016/j.infpip.2022.100261. Epub 2022 Nov 29. PMID: 36465098; PMCID: PMC9705264.

34: Tam AR, Zhang RR, Lung KC, Liu R, Leung KY, Liu D, Fan Y, Lu L, Lam AH, Chung TW, Yip CC, Lo J, Wu AK, Lee R, Sin S, Ng PY, Chan WM, Shum HP, Yan WW, Chan JF, Cheng VC, Lau CS, To KK, Chan KH, Yuen KY, Hung IF. Early Treatment of High-Risk Hospitalized Coronavirus Disease 2019 (COVID-19) Patients With a Combination of Interferon Beta-1b and Remdesivir: A Phase 2 Open-label Randomized Controlled Trial. Clin Infect Dis. 2023 Feb 8;76(3):e216-e226. doi: 10.1093/cid/ciac523. PMID: 35762834; PMCID: PMC9278225.

35: Fong CH, Zhang X, Chen LL, Poon RW, Chan BP, Zhao Y, Wong CK, Chan KH, Yuen KY, Hung IF, Yuen JKY, To KK. Effect of vaccine booster, vaccine type, and hybrid immunity on humoral and cellular immunity against SARS-CoV-2 ancestral strain and Omicron variant sublineages BA.2 and BA.5 among older adults with comorbidities: a cross sectional study. EBioMedicine. 2023 Feb;88:104446. doi: 10.1016/j.ebiom.2023.104446. Epub 2023 Jan 25. PMID: 36706582; PMCID: PMC9874281.

36: Chan JF, Huang X, Hu B, Chai Y, Shi H, Zhu T, Yuen TT, Liu Y, Liu H, Shi J, Wen L, Shuai H, Hou Y, Yoon C, Cai JP, Zhang AJ, Zhou J, Yin F, Yuan S, Zhang BZ, Brindley MA, Shi ZL, Yuen KY, Chu H. Altered host protease determinants for SARS-CoV-2 Omicron. Sci Adv. 2023 Jan 20;9(3):eadd3867. doi: 10.1126/sciadv.add3867. Epub 2023 Jan 20. PMID: 36662861; PMCID: PMC9858505.

37: Tsang PYL, Chu SLH, Li LCW, Tai DMS, Cheung BKC, Kebede FT, Leung PYM, Wong W, Chung T, Yip CCY, Poon RWS, Chen JHK, Yuen KY, Fok M, Lau JYN, Lau LT. Automated System for Multiplexing Detection of COVID-19 and Other Respiratory Pathogens. IEEE J Transl Eng Health Med. 2022 Dec 19;11:424-434. doi: 10.1109/JTEHM.2022.3230716. PMID: 37435542; PMCID: PMC10332469.

38: Yip CC, Sridhar S, Chan WM, Ip JD, Chu AW, Leung KH, Cheng VC, Yuen KY, To KK. Development and Validation of a Novel COVID-19 nsp8 One-Tube RT-LAMP-CRISPR Assay for SARS-CoV-2 Diagnosis. Microbiol Spectr. 2022 Dec 21;10(6):e0196222. doi: 10.1128/spectrum.01962-22. Epub 2022 Nov 29. PMID: 36445095; PMCID: PMC9769742.

39: Liu X, Li C, Wan Z, Chiu MC, Huang J, Yu Y, Zhu L, Cai JP, Rong L, Song YQ, Chu H, Cai Z, Jiang S, Yuen KY, Zhou J. Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids. Signal Transduct Target Ther. 2022 Dec 19;7(1):392. doi: 10.1038/s41392-022-01247-w. PMID: 36529763; PMCID: PMC9760641.

40: Chan CM, Tse H, Wong SSY, Woo PCY, Lau SKP, Chen L, Zheng BJ, Huang JD, Yuen KY. Corrigendum to “Examination of seroprevalence of coronavirus HKU1 infection with S protein-based ELISA and neutralization assay against viral spike pseudotyped virus” Journal of Clinical Virology 45 (2009) 54-60. J Clin Virol. 2022 Dec;157:105295. doi: 10.1016/j.jcv.2022.105295. Epub 2022 Oct 26. Erratum for: J Clin Virol. 2009 May;45(1):54-60. PMID: 36307272; PMCID: PMC9597574.

41: Hu B, Chan JF, Liu H, Liu Y, Chai Y, Shi J, Shuai H, Hou Y, Huang X, Yuen TT, Yoon C, Zhu T, Zhang J, Li W, Zhang AJ, Zhou J, Yuan S, Zhang BZ, Yuen KY, Chu H. Spike mutations contributing to the altered entry preference of SARS- CoV-2 omicron BA.1 and BA.2. Emerg Microbes Infect. 2022 Dec;11(1):2275-2287. doi: 10.1080/22221751.2022.2117098. PMID: 36039901; PMCID: PMC9542985.

42: Liang R, Ye ZW, Ong CP, Qin Z, Xie Y, Fan Y, Tang K, Poon VK, Chan CC, Yang X, Cao H, Wang K, Sun H, Hu B, Cai JP, Luo C, Chik KK, Chu H, Zheng Y, Yuen KY, Chan JF, Jin DY, Yuan S. The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage. Emerg Microbes Infect. 2022 Dec;11(1):2093-2101. doi: 10.1080/22221751.2022.2111977. PMID: 35943779; PMCID: PMC9448440.

43: Poon RW, Chan BP, Chan WM, Fong CH, Zhang X, Lu L, Chen LL, Lam JY, Cheng VC, Wong SSY, Kok KH, Yuen KY, To KK. SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong Kong. Emerg Microbes Infect. 2022 Dec;11(1):2116-2119. doi: 10.1080/22221751.2022.2106899. PMID: 35880656; PMCID: PMC9448364.

44: Yuan S, Gao X, Tang K, Cai JP, Hu M, Luo P, Wen L, Ye ZW, Luo C, Tsang JO, Chan CC, Huang Y, Cao J, Liang R, Qin Z, Qin B, Yin F, Chu H, Jin DY, Sun R, Chan JF, Cui S, Yuen KY. Targeting papain-like protease for broad-spectrum coronavirus inhibition. Protein Cell. 2022 Dec;13(12):940-953. doi: 10.1007/s13238-022-00909-3. Epub 2022 Apr 6. PMID: 35384604; PMCID: PMC8983325.

45: Lam JY, Ng YY, Yuen CK, Wong WM, Yuen KY, Kok KH. A nasal omicron vaccine booster elicits potent neutralizing antibody response against emerging SARS- CoV-2 variants. Emerg Microbes Infect. 2022 Dec;11(1):964-967. doi: 10.1080/22221751.2022.2053365. PMID: 35275039; PMCID: PMC8973333.

46: Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY. Fusion-inhibition peptide broadly inhibits influenza virus and SARS- CoV-2, including Delta and Omicron variants. Emerg Microbes Infect. 2022 Dec;11(1):926-937. doi: 10.1080/22221751.2022.2051753. PMID: 35259078; PMCID: PMC8973381.

47: Kok KH, Wong SC, Chan WM, Wen L, Chu AW, Ip JD, Lee LK, Wong IT, Lo HW, Cheng VC, Ho AY, Lam BH, Tse H, Lung D, Ng KNH, Au AK, Siu GK, Yuen KY. Co- circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong. Emerg Microbes Infect. 2022 Dec;11(1):689-698. doi: 10.1080/22221751.2022.2040922. PMID: 35135441; PMCID: PMC8890519.

48: Chen LL, Chua GT, Lu L, Chan BP, Wong JS, Chow CC, Yu TC, Leung AS, Lam SY, Wong TW, Tsang HW, Wong IC, Chan KH, Yuen KY, Ip P, Kwan MY, To KK. Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine. Emerg Microbes Infect. 2022 Dec;11(1):543-547. doi: 10.1080/22221751.2022.2035195. PMID: 35084295; PMCID: PMC8843159.

49: Zhang X, Chu H, Chik KK, Wen L, Shuai H, Yang D, Wang Y, Hou Y, Yuen TT, Cai JP, Yuan S, Yin F, Yuen KY, Chan JF. hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs. Emerg Microbes Infect. 2022 Dec;11(1):519-531. doi: 10.1080/22221751.2022.2032372. PMID: 35060842; PMCID: PMC8843244.

50: Chen Y, Li C, Liu F, Ye Z, Song W, Lee ACY, Shuai H, Lu L, To KK, Chan JF, Zhang AJ, Chu H, Yuen KY. Age-associated SARS-CoV-2 breakthrough infection and changes in immune response in a mouse model. Emerg Microbes Infect. 2022 Dec;11(1):368-383. doi: 10.1080/22221751.2022.2026741. PMID: 34989330; PMCID: PMC8794076.

51: Zhao H, Lu L, Peng Z, Chen LL, Meng X, Zhang C, Ip JD, Chan WM, Chu AW, Chan KH, Jin DY, Chen H, Yuen KY, To KK. SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells. Emerg Microbes Infect. 2022 Dec;11(1):277-283. doi: 10.1080/22221751.2021.2023329. PMID: 34951565; PMCID: PMC8774049.

52: Wang P, Casner RG, Nair MS, Yu J, Guo Y, Wang M, Chan JF, Cerutti G, Iketani S, Liu L, Sheng Z, Chen Z, Yuen KY, Kwong PD, Huang Y, Shapiro L, Ho DD. A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. Emerg Microbes Infect. 2022 Dec;11(1):147-157. doi: 10.1080/22221751.2021.2011623. PMID: 34836485; PMCID: PMC8725896.

53: Wong SC, Au AK, Lo JY, Ho PL, Hung IF, To KK, Yuen KY, Cheng VC. Evolution and Control of COVID-19 Epidemic in Hong Kong. Viruses. 2022 Nov 14;14(11):2519. doi: 10.3390/v14112519. PMID: 36423128; PMCID: PMC9698160.

54: Chan JF, Oh YJ, Yuan S, Chu H, Yeung ML, Canena D, Chan CC, Poon VK, Chan CC, Zhang AJ, Cai JP, Ye ZW, Wen L, Yuen TT, Chik KK, Shuai H, Wang Y, Hou Y, Luo C, Chan WM, Qin Z, Sit KY, Au WK, Legendre M, Zhu R, Hain L, Seferovic H, Tampé R, To KK, Chan KH, Thomas DG, Klausberger M, Xu C, Moon JJ, Stadlmann J, Penninger JM, Oostenbrink C, Hinterdorfer P, Yuen KY, Markovitz DM. A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS- CoV-2 and MERS-CoV infection in vivo. Cell Rep Med. 2022 Oct 18;3(10):100774. doi: 10.1016/j.xcrm.2022.100774. Epub 2022 Sep 29. PMID: 36195094; PMCID: PMC9519379.

55: Wong SC, Yuen LL, Chan VW, Chen JH, To KK, Yuen KY, Cheng VC. Airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): What is the implication of hospital infection control? Infect Control Hosp Epidemiol. 2022 Oct;43(10):1522-1523. doi: 10.1017/ice.2021.318. Epub 2021 Jul 12. PMID: 34250877; PMCID: PMC8319673.

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61: Cheng VCC, Ip JD, Chu AWH, Tam AR, Chan WM, Abdullah SMU, Chan BPC, Wong SC, Kwan MYW, Chua GT, Ip P, Chan JMC, Lam BHS, To WK, Chuang VWM, Yuen KY, Hung IFN, To KKW. Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Subvariant BA.2 in a Single-Source Community Outbreak. Clin Infect Dis. 2022 Aug 24;75(1):e44-e49. doi: 10.1093/cid/ciac203. PMID: 35271728; PMCID: PMC8992238.

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64: Li X, Chan JMC, Lam B, Lung DC, Lung KC, Chow CKY, Tam T, Chiu KHY, Hung LL, Hung IFN, Cheng VCC, To KKW, Yuen KY. Coronavirus Disease 2019 Messenger RNA Vaccines Associated With Delayed Onset of Breakthrough Infections and Fewer Radiographic Abnormalities. Clin Infect Dis. 2022 Aug 24;75(1):e905-e908. doi: 10.1093/cid/ciab1062. PMID: 34984442; PMCID: PMC8755373.

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70: Cheng VC, Wong SC, Au AK, Zhang C, Chen JH, So SY, Li X, Wang Q, Lu KK, Lung DC, Chuang VW, Schuldenfrei E, Siu GK, To KK, Li Y, Yuen KY. Explosive outbreak of SARS-CoV-2 Omicron variant is associated with vertical transmission in high- rise residential buildings in Hong Kong. Build Environ. 2022 Aug 1;221:109323. doi: 10.1016/j.buildenv.2022.109323. Epub 2022 Jun 24. PMID: 35765578; PMCID: PMC9225940.

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73: Yan B, Yuan S, Cao J, Fung K, Lai PM, Yin F, Sze KH, Qin Z, Xie Y, Ye ZW, Yuen TT, Chik KK, Tsang JO, Zou Z, Chan CC, Luo C, Cai JP, Chan KH, Chung TW, Tam AR, Chu H, Jin DY, Hung IF, Yuen KY, Kao RY, Chan JF. Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway. Int J Biol Sci. 2022 Jul 11;18(12):4744-4755. doi: 10.7150/ijbs.73057. PMID: 35874954; PMCID: PMC9305268.

74: Zhao H, To KK, Lam H, Zhang C, Peng Z, Meng X, Wang X, Zhang AJ, Yan B, Cai J, Yeung ML, Chan JF, Yuen KY. A trifunctional peptide broadly inhibits SARS- CoV-2 Delta and Omicron variants in hamsters. Cell Discov. 2022 Jun 30;8(1):62. doi: 10.1038/s41421-022-00428-9. PMID: 35768416; PMCID: PMC9243000.

75: Chen LL, Abdullah SMU, Chan WM, Chan BP, Ip JD, Chu AW, Lu L, Zhang X, Zhao Y, Chuang VW, Au AK, Cheng VC, Sridhar S, Yuen KY, Hung IF, Chan KH, To KK. Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong. Nat Commun. 2022 Jun 24;13(1):3618. doi: 10.1038/s41467-022-31395-0. PMID: 35750868; PMCID: PMC9232516.

76: Zhou B, Zhou R, Tang B, Chan JF, Luo M, Peng Q, Yuan S, Liu H, Mok BW, Chen B, Wang P, Poon VK, Chu H, Chan CC, Tsang JO, Chan CC, Au KK, Man HO, Lu L, To KK, Chen H, Yuen KY, Dang S, Chen Z. A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge. Nat Commun. 2022 Jun 23;13(1):3589. doi: 10.1038/s41467-022-31259-7. PMID: 35739114; PMCID: PMC9223271.

77: Chiu MC, Li C, Liu X, Yu Y, Huang J, Wan Z, Xiao D, Chu H, Cai JP, Zhou B, Sit KY, Au WK, Wong KK, Li G, Chan JF, To KK, Chen Z, Jiang S, Clevers H, Yuen KY, Zhou J. A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant. Cell Discov. 2022 Jun 17;8(1):57. doi: 10.1038/s41421-022-00422-1. PMID: 35710786; PMCID: PMC9203776.

78: Li C, Chen Y, Zhao Y, Lung DC, Ye Z, Song W, Liu FF, Cai JP, Wong WM, Yip CC, Chan JF, To KK, Sridhar S, Hung IF, Chu H, Kok KH, Jin DY, Zhang AJ, Yuen KY. Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model. Clin Infect Dis. 2022 Jun 10;74(11):1933-1950. doi: 10.1093/cid/ciab707. Erratum in: Clin Infect Dis. 2021 Dec 16;73(12):2372-2373. PMID: 34406358; PMCID: PMC8436386.

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80: Cheng VC, Wong SC, So SY, Chen JH, Chau PH, Au AK, Chiu KH, Li X, Ip P, Chuang VW, Lung DC, Tse CW, Lee RA, Fung KS, To WK, Lai RW, Que TL, Lo JY, Yuen KY. Decreased Antibiotic Consumption Coincided with Reduction in Bacteremia Caused by Bacterial Species with Respiratory Transmission Potential during the COVID-19 Pandemic. Antibiotics (Basel). 2022 May 31;11(6):746. doi: 10.3390/antibiotics11060746. PMID: 35740153; PMCID: PMC9219721.

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87: Chen LL, Lu L, Choi CY, Cai JP, Tsoi HW, Chu AW, Ip JD, Chan WM, Zhang RR, Zhang X, Tam AR, Lau DP, To WK, Que TL, Yip CC, Chan KH, Cheng VC, Yuen KY, Hung IF, To KK. Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2) Variant-Associated Receptor Binding Domain (RBD) Mutations on the Susceptibility to Serum Antibodies Elicited by Coronavirus Disease 2019 (COVID-19) Infection or Vaccination. Clin Infect Dis. 2022 May 3;74(9):1623-1630. doi: 10.1093/cid/ciab656. PMID: 34309648.

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97: Wang Q, Lung DC, Chan PT, Jia W, Dung CH, Miao T, Huang J, Chen W, Wang Z, Leung KM, Xu P, Lin Z, Wong D, Tse H, Ying Wong SC, Choi GK, To KK, Cheng VC, Yuen KY, Li Y. High attack rate in a Tong Lau house outbreak of COVID-19 with subdivided units in Hong Kong. Interface Focus. 2022 Feb 11;12(2):20210063. doi: 10.1098/rsfs.2021.0063. PMID: 35261729; PMCID: PMC8831081.

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100: Xia S, Chan JF, Wang L, Jiao F, Chik KK, Chu H, Lan Q, Xu W, Wang Q, Wang C, Yuen KY, Lu L, Jiang S. Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant. Cell Res. 2022 Apr;32(4):404-406. doi: 10.1038/s41422-022-00617-x. Epub 2022 Jan 27. PMID: 35087243; PMCID: PMC8793821.

101: Hu YF, Hu JC, Gong HR, Danchin A, Sun R, Chu H, Hung IF, Yuen KY, To KK, Zhang BZ, Yau T, Huang JD. Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants. Front Immunol. 2022 Mar 24;13:861050. doi: 10.3389/fimmu.2022.861050. PMID: 35401572; PMCID: PMC8987580.

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106: Li X, Chen H, Lu L, Chen LL, Chan BP, Wong SC, Cheng VC, Yuen KY, Chan KH, To KK. High compliance to infection control measures prevented guest-to-staff transmission in COVID-19 quarantine hotels. J Infect. 2022 Mar;84(3):418-467. doi: 10.1016/j.jinf.2021.10.016. Epub 2021 Oct 27. PMID: 34715237; PMCID: PMC8548840.

107: Cheng VC, Wong SC, Tong DW, Chuang VW, Chen JH, Lee LL, To KK, Hung IF, Ho PL, Yeung DT, Chung KL, Yuen KY. Multipronged infection control strategy to achieve zero nosocomial coronavirus disease 2019 (COVID-19) cases among Hong Kong healthcare workers in the first 300 days of the pandemic. Infect Control Hosp Epidemiol. 2022 Mar;43(3):334-343. doi: 10.1017/ice.2021.119. Epub 2021 Mar 19. PMID: 33736729; PMCID: PMC8060541.

108: Wang R, Chan JF, Wang S, Li H, Zhao J, Ip TK, Zuo Z, Yuen KY, Yuan S, Sun H. Orally administered bismuth drug together with <i>N</i>-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy. Chem Sci. 2021 Dec 3;13(8):2238-2248. doi: 10.1039/d1sc04515f. PMID: 35310492; PMCID: PMC8864717.

109: Chua GT, Wong JSC, Chung J, Lam I, Kwong J, Leung K, Law CY, Lam CW, Kwok J, Chu PWK, Au EYL, Lam CK, Mak D, Fong NC, Leung D, Wong WHS, Ho MHK, Tsao SSL, Wong CS, Yam JC, Tso WWY, To KKW, Tam PKH, Chan GCF, Leung WH, Yuen KY, Novelli V, Klein N, Levin M, Whitaker E, Lau YL, Ip P, Kwan MYW. Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2: a case report. Hong Kong Med J. 2022 Feb;28(1):76-78. doi: 10.12809/hkmj219689. Epub 2022 Feb 14. PMID: 35249890.

110: Liu L, Iketani S, Guo Y, Chan JF, Wang M, Liu L, Luo Y, Chu H, Huang Y, Nair MS, Yu J, Chik KK, Yuen TT, Yoon C, To KK, Chen H, Yin MT, Sobieszczyk ME, Huang Y, Wang HH, Sheng Z, Yuen KY, Ho DD. Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature. 2022 Feb;602(7898):676-681. doi: 10.1038/s41586-021-04388-0. Epub 2021 Dec 23. PMID: 35016198.

111: Khong KW, Liu D, Leung KY, Lu L, Lam HY, Chen L, Chan PC, Lam HM, Xie X, Zhang R, Fan Y, To KK, Chen H, Yuen KY, Chan KH, Hung IF. Antibody Response of Combination of BNT162b2 and CoronaVac Platforms of COVID-19 Vaccines against Omicron Variant. Vaccines (Basel). 2022 Jan 21;10(2):160. doi: 10.3390/vaccines10020160. PMID: 35214619; PMCID: PMC8877145.

112: Mo Y, To KK, Zhou R, Liu L, Cao T, Huang H, Du Z, Lim CYH, Yim LY, Luk TY, Chan JM, Chik TS, Lau DP, Tsang OT, Tam AR, Hung IF, Yuen KY, Chen Z. Mitochondrial Dysfunction Associates With Acute T Lymphocytopenia and Impaired Functionality in COVID-19 Patients. Front Immunol. 2022 Jan 14;12:799896. doi: 10.3389/fimmu.2021.799896. PMID: 35095881; PMCID: PMC8795605.

113: Wang Q, Li Y, Lung DC, Chan PT, Dung CH, Jia W, Miao T, Huang J, Chen W, Wang Z, Leung KM, Lin Z, Wong D, Tse H, Wong SCY, Choi GK, Lam JY, To KK, Cheng VC, Yuen KY. Aerosol transmission of SARS-CoV-2 due to the chimney effect in two high-rise housing drainage stacks. J Hazard Mater. 2022 Jan 5;421:126799. doi: 10.1016/j.jhazmat.2021.126799. Epub 2021 Aug 2. PMID: 34396958; PMCID: PMC8327615.

114: Zhang R, Liu D, Leung KY, Fan Y, Lu L, Chan PC, To KK, Chen H, Yuen KY, Chan KH, Hung IF. Immunogenicity of a Heterologous Prime-Boost COVID-19 Vaccination with mRNA and Inactivated Virus Vaccines Compared with Homologous Vaccination Strategy against SARS-CoV-2 Variants. Vaccines (Basel). 2022 Jan 3;10(1):72. doi: 10.3390/vaccines10010072. PMID: 35062734; PMCID: PMC8781520.

115: Zhao H, Yuen KY. Broad-spectrum Respiratory Virus Entry Inhibitors. Adv Exp Med Biol. 2022;1366:137-153. doi: 10.1007/978-981-16-8702-0_9. PMID: 35412139.

116: Zhou R, To KK, Peng Q, Chan JM, Huang H, Yang D, Lam BH, Chuang VW, Cai JP, Liu N, Au KK, Tsang OT, Yuen KY, Chen Z. Vaccine-breakthrough infection by the SARS-CoV-2 omicron variant elicits broadly cross-reactive immune responses. Clin Transl Med. 2022 Jan;12(1):e720. doi: 10.1002/ctm2.720. PMID: 35083867; PMCID: PMC8792449.

117: Wong SC, Au AK, Chen H, Yuen LL, Li X, Lung DC, Chu AW, Ip JD, Chan WM, Tsoi HW, To KK, Yuen KY, Cheng VC. Transmission of Omicron (B.1.1.529) – SARS- CoV-2 Variant of Concern in a designated quarantine hotel for travelers: a challenge of elimination strategy of COVID-19. Lancet Reg Health West Pac. 2022 Jan;18:100360. doi: 10.1016/j.lanwpc.2021.100360. Epub 2021 Dec 23. PMID: 34961854; PMCID: PMC8696199.

118: Zhou R, Wang P, Wong YC, Xu H, Lau SY, Liu L, Mok BW, Peng Q, Liu N, Woo KF, Deng S, Tam RC, Huang H, Zhang AJ, Zhou D, Zhou B, Chan CY, Du Z, Yang D, Au KK, Yuen KY, Chen H, Chen Z. Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models. EBioMedicine. 2022 Jan;75:103762. doi: 10.1016/j.ebiom.2021.103762. Epub 2021 Dec 21. PMID: 34942445; PMCID: PMC8687884.

119: Tsang HW, Chua GT, To KKW, Wong JSC, Tu W, Kwok JSY, Wong WHS, Wang X, Zhang Y, Rosa Duque JS, Chan GCF, Chu WK, Pang CP, Tam PKH, Lau YL, Wong ICK, Leung WH, Yuen KY, Kwan MYW, Ip P. Assessment of SARS-CoV-2 Immunity in Convalescent Children and Adolescents. Front Immunol. 2021 Dec 17;12:797919. doi: 10.3389/fimmu.2021.797919. PMID: 34975908; PMCID: PMC8718543.

120: Li C, Chen Y, Zhao Y, Christopher Lung D, Ye Z, Song W, Liu FF, Cai JP, Wong WM, Chik-YanYip C, Fuk-Woo Chan J, Kai-Wang To K, Sridhar S, Fan-Ngai Hung I, Chu H, Kok KH, Jin DY, JinxiaZhang A, Yuen KY. Corrigendum to: Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model. Clin Infect Dis. 2021 Dec 16;73(12):2372-2373. doi: 10.1093/cid/ciab941. Erratum for: Clin Infect Dis. 2021 Aug 18;: PMID: 34849654; PMCID: PMC8690168.

121: Lam AH, Cai JP, Leung KY, Zhang RR, Liu D, Fan Y, Tam AR, Cheng VC, To KK, Yuen KY, Hung IF, Chan KH. In-House Immunofluorescence Assay for Detection of SARS-CoV-2 Antigens in Cells from Nasopharyngeal Swabs as a Diagnostic Method for COVID-19. Diagnostics (Basel). 2021 Dec 13;11(12):2346. doi: 10.3390/diagnostics11122346. PMID: 34943583; PMCID: PMC8700487.

122: Zhang R, Khong KW, Leung KY, Liu D, Fan Y, Lu L, Chan PC, Chen L, To KK, Chen H, Yuen KY, Chan KH, Hung IF. Antibody Response of BNT162b2 and CoronaVac Platforms in Recovered Individuals Previously Infected by COVID-19 against SARS- CoV-2 Wild Type and Delta Variant. Vaccines (Basel). 2021 Dec 7;9(12):1442. doi: 10.3390/vaccines9121442. PMID: 34960189; PMCID: PMC8705363.

123: Cheng VC, Siu GK, Wong SC, Au AK, Ng CS, Chen H, Li X, Lee LK, Leung JS, Lu KK, Lo HW, Wong EY, Luk S, Lam BH, To WK, Lee RA, Lung DC, Kwan MY, Tse H, Chuang SK, To KK, Yuen KY. Complementation of contact tracing by mass testing for successful containment of beta COVID-19 variant (SARS-CoV-2 VOC B.1.351) epidemic in Hong Kong. Lancet Reg Health West Pac. 2021 Dec;17:100281. doi: 10.1016/j.lanwpc.2021.100281. Epub 2021 Oct 1. PMID: 34611629; PMCID: PMC8483778.

124: Wang X, Lam JY, Chen L, Au SW, To KKW, Yuen KY, Kok KH. Mining of linear B cell epitopes of SARS-CoV-2 ORF8 protein from COVID-19 patients. Emerg Microbes Infect. 2021 Dec;10(1):1016-1023. doi: 10.1080/22221751.2021.1931465. PMID: 34003073; PMCID: PMC8186430.

125: Zhang BZ, Wang X, Yuan S, Li W, Dou Y, Poon VK, Chan CC, Cai JP, Chik KK, Tang K, Chan CC, Hu YF, Hu JC, Badea SR, Gong HR, Lin X, Chu H, Li X, To KK, Liu L, Chen Z, Hung IF, Yuen KY, Chan JF, Huang JD. A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters. Emerg Microbes Infect. 2021 Dec;10(1):874-884. doi: 10.1080/22221751.2021.1921621. PMID: 33890550; PMCID: PMC8118541.

126: To KK, Sridhar S, Chiu KH, Hung DL, Li X, Hung IF, Tam AR, Chung TW, Chan JF, Zhang AJ, Cheng VC, Yuen KY. Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic. Emerg Microbes Infect. 2021 Dec;10(1):507-535. doi: 10.1080/22221751.2021.1898291. PMID: 33666147; PMCID: PMC8006950.

127: Ye ZW, Yuan S, Chan JF, Zhang AJ, Yu CY, Ong CP, Yang D, Chan CC, Tang K, Cao J, Poon VK, Chan CC, Cai JP, Chu H, Yuen KY, Jin DY. Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection. Emerg Microbes Infect. 2021 Dec;10(1):291-304. doi: 10.1080/22221751.2021.1885998. PMID: 33538646; PMCID: PMC7919885.

128: Poon RW, Lu L, Fong CH, Ip TC, Chen LL, Zhang RR, Yip CC, Cheng VC, Chan KH, Yuen KY, To KK. Correlation between Commercial Anti-RBD IgG Titer and Neutralization Titer against SARS-CoV-2 Beta Variant. Diagnostics (Basel). 2021 Nov 27;11(12):2216. doi: 10.3390/diagnostics11122216. PMID: 34943453; PMCID: PMC8700542.

129: Yamaguchi T, Hoshizaki M, Minato T, Nirasawa S, Asaka MN, Niiyama M, Imai M, Uda A, Chan JF, Takahashi S, An J, Saku A, Nukiwa R, Utsumi D, Kiso M, Yasuhara A, Poon VK, Chan CC, Fujino Y, Motoyama S, Nagata S, Penninger JM, Kamada H, Yuen KY, Kamitani W, Maeda K, Kawaoka Y, Yasutomi Y, Imai Y, Kuba K. ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. Nat Commun. 2021 Nov 23;12(1):6791. doi: 10.1038/s41467-021-27097-8. PMID: 34815389; PMCID: PMC8610983.

130: Tse H, Lung DC, Wong SC, Ip KF, Wu TC, To KK, Kok KH, Yuen KY, Choi GK. Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 Virus Variant With Novel Genomic Architecture in Hong Kong. Clin Infect Dis. 2021 Nov 2;73(9):1696-1699. doi: 10.1093/cid/ciab198. PMID: 33675655; PMCID: PMC7989571.

131: To KK, Hung IF, Ip JD, Chu AW, Chan WM, Tam AR, Fong CH, Yuan S, Tsoi HW, Ng AC, Lee LL, Wan P, Tso EY, To WK, Tsang DN, Chan KH, Huang JD, Kok KH, Cheng VC, Yuen KY. Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing. Clin Infect Dis. 2021 Nov 2;73(9):e2946-e2951. doi: 10.1093/cid/ciaa1275. PMID: 32840608; PMCID: PMC7499500.

132: Shuai H, Chan JF, Yuen TT, Yoon C, Hu JC, Wen L, Hu B, Yang D, Wang Y, Hou Y, Huang X, Chai Y, Chan CC, Poon VK, Lu L, Zhang RQ, Chan WM, Ip JD, Chu AW, Hu YF, Cai JP, Chan KH, Zhou J, Sridhar S, Zhang BZ, Yuan S, Zhang AJ, Huang JD, To KK, Yuen KY, Chu H. Emerging SARS-CoV-2 variants expand species tropism to murines. EBioMedicine. 2021 Nov;73:103643. doi: 10.1016/j.ebiom.2021.103643. Epub 2021 Oct 21. PMID: 34689086; PMCID: PMC8530107.

133: Yuan S, Yan B, Cao J, Ye ZW, Liang R, Tang K, Luo C, Cai J, Chu H, Chung TW, To KK, Hung IF, Jin DY, Chan JF, Yuen KY. SARS-CoV-2 exploits host DGAT and ADRP for efficient replication. Cell Discov. 2021 Oct 26;7(1):100. doi: 10.1038/s41421-021-00338-2. PMID: 34702802; PMCID: PMC8548329.

134: Wang P, Casner RG, Nair MS, Yu J, Guo Y, Wang M, Chan JF, Cerutti G, Iketani S, Liu L, Sheng Z, Chen Z, Yuen KY, Kwong PD, Huang Y, Shapiro L, Ho DD. A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses. bioRxiv [Preprint]. 2021 Oct 14:2021.10.13.464307. doi: 10.1101/2021.10.13.464307. Update in: Emerg Microbes Infect. 2021 Nov 26;:1-34. PMID: 34671769; PMCID: PMC8528075.

135: Banach BB, Cerutti G, Fahad AS, Shen CH, Oliveira De Souza M, Katsamba PS, Tsybovsky Y, Wang P, Nair MS, Huang Y, Francino-Urdániz IM, Steiner PJ, Gutiérrez-González M, Liu L, López Acevedo SN, Nazzari AF, Wolfe JR, Luo Y, Olia AS, Teng IT, Yu J, Zhou T, Reddem ER, Bimela J, Pan X, Madan B, Laflin AD, Nimrania R, Yuen KY, Whitehead TA, Ho DD, Kwong PD, Shapiro L, DeKosky BJ. Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses. Cell Rep. 2021 Oct 5;37(1):109771. doi: 10.1016/j.celrep.2021.109771. Epub 2021 Sep 28. PMID: 34587480; PMCID: PMC8479507.

136: Wong SC, Lam GK, Chen JH, Li X, Ip FT, Yuen LL, Chan VW, AuYeung CH, So SY, Ho PL, Yuen KY, Cheng VC. Air dispersal of multidrug-resistant Acinetobacter baumannii: implications for nosocomial transmission during the COVID-19 pandemic. J Hosp Infect. 2021 Oct;116:78-86. doi: 10.1016/j.jhin.2021.08.005. Epub 2021 Aug 14. PMID: 34403765; PMCID: PMC8429036.

137: Kwan MYW, Chua GT, Chow CB, Tsao SSL, To KKW, Yuen KY, Lau YL, Ip P. mRNA COVID vaccine and myocarditis in adolescents. Hong Kong Med J. 2021 Oct;27(5):326-327. doi: 10.12809/hkmj215120. Epub 2021 Aug 16. PMID: 34393110.

138: Chan KH, Leung KY, Zhang RR, Liu D, Fan Y, Chen H, Yuen KY, Hung IF. Performance of a Surrogate SARS-CoV-2-Neutralizing Antibody Assay in Natural Infection and Vaccination Samples. Diagnostics (Basel). 2021 Sep 24;11(10):1757. doi: 10.3390/diagnostics11101757. PMID: 34679455; PMCID: PMC8534648.

139: Mok BW, Liu H, Deng S, Liu J, Zhang AJ, Lau SY, Liu S, Tam RC, Cremin CJ, Ng TT, Leung JS, Lee LK, Wang P, To KK, Chan JF, Chan KH, Yuen KY, Siu GK, Chen H. Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters. Commun Biol. 2021 Sep 20;4(1):1102. doi: 10.1038/s42003-021-02640-x. PMID: 34545191; PMCID: PMC8452646.

140: Cheng VC, Fung KS, Siu GK, Wong SC, Cheng LS, Wong MS, Lee LK, Chan WM, Chau KY, Leung JS, Chu AW, Chan WS, Lu KK, Tam KK, Ip JD, Leung KS, Lung DC, Tse H, To KK, Yuen KY. Nosocomial Outbreak of Coronavirus Disease 2019 by Possible Airborne Transmission Leading to a Superspreading Event. Clin Infect Dis. 2021 Sep 15;73(6):e1356-e1364. doi: 10.1093/cid/ciab313. PMID: 33851214; PMCID: PMC8083289.

141: Lu L, Chu AW, Zhang RR, Chan WM, Ip JD, Tsoi HW, Chen LL, Cai JP, Lung DC, Tam AR, Yau YS, Kwan MY, To WK, Tsang OT, Lee LL, Yi H, Ip TC, Poon RW, Siu GK, Mok BW, Cheng VC, Chan KH, Yuen KY, Hung IF, To KK. The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum. EBioMedicine. 2021 Sep;71:103544. doi: 10.1016/j.ebiom.2021.103544. Epub 2021 Aug 19. PMID: 34419925; PMCID: PMC8374549.

142: Wong SC, Chen H, Lung DC, Ho PL, Yuen KY, Cheng VC. To prevent SARS-CoV-2 transmission in designated quarantine hotel for travelers: Is the ventilation system a concern? Indoor Air. 2021 Sep;31(5):1295-1297. doi: 10.1111/ina.12870. Epub 2021 Jul 14. PMID: 34259364; PMCID: PMC8447387.

143: Wong SC, Leung M, Tong DW, Lee LL, Leung WL, Chan FW, Chen JH, Hung IF, Yuen KY, Yeung DT, Chung KL, Cheng VC. Infection control challenges in setting up community isolation and treatment facilities for patients with coronavirus disease 2019 (COVID-19): Implementation of directly observed environmental disinfection. Infect Control Hosp Epidemiol. 2021 Sep;42(9):1037-1045. doi: 10.1017/ice.2020.1355. Epub 2020 Dec 7. PMID: 33280617; PMCID: PMC7889843.

144: Ip JD, Kok KH, Chan WM, Chu AW, Wu WL, Yip CC, To WK, Tsang OT, Leung WS, Chik TS, Chan KH, Hung IF, Yuen KY, To KK. Intra-host non-synonymous diversity at a neutralizing antibody epitope of SARS-CoV-2 spike protein N-terminal domain. Clin Microbiol Infect. 2021 Sep;27(9):1350.e1-1350.e5. doi: 10.1016/j.cmi.2020.10.030. Epub 2020 Nov 2. PMID: 33144203; PMCID: PMC7605743.

145: Bohn MK, Lippi G, Horvath AR, Erasmus R, Grimmler M, Gramegna M, Mancini N, Mueller R, Rawlinson WD, Menezes ME, Patru MM, Rota F, Sethi S, Singh K, Yuen KY, Wang CB, Adeli K; IFCC Taskforce on COVID-19. IFCC interim guidelines on rapid point-of-care antigen testing for SARS-CoV-2 detection in asymptomatic and symptomatic individuals. Clin Chem Lab Med. 2021 Apr 28;59(9):1507-1515. doi: 10.1515/cclm-2021-0455. PMID: 33908222.

146: Li C, Chen YX, Liu FF, Lee AC, Zhao Y, Ye ZH, Cai JP, Chu H, Zhang RQ, Chan KH, Chiu KH, Lung DC, Sridhar S, Hung IF, To KK, Zhang AJ, Chan JF, Yuen KY. Absence of Vaccine-enhanced Disease With Unexpected Positive Protection Against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by Inactivated Vaccine Given Within 3 Days of Virus Challenge in Syrian Hamster Model. Clin Infect Dis. 2021 Aug 2;73(3):e719-e734. doi: 10.1093/cid/ciab083. PMID: 33515458; PMCID: PMC7929057.

147: Wong SC, Yuen LLH, Chen JHK, Yuen KY, Cheng VCC. Infection control challenges in handling recurrent blockage of sewage pipes in isolation facility designated for patients with COVID-19. J Hosp Infect. 2021 Aug;114:187-189. doi: 10.1016/j.jhin.2021.03.002. Epub 2021 Mar 7. PMID: 33691161; PMCID: PMC7937326.

148: Zhang AJ, Lee AC, Chu H, Chan JF, Fan Z, Li C, Liu F, Chen Y, Yuan S, Poon VK, Chan CC, Cai JP, Wu KL, Sridhar S, Chan YS, Yuen KY. Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters. Clin Infect Dis. 2021 Jul 15;73(2):e503-e512. doi: 10.1093/cid/ciaa995. PMID: 32667973; PMCID: PMC7454453.

149: Wong YC, Lau SY, Wang To KK, Mok BWY, Li X, Wang P, Deng S, Woo KF, Du Z, Li C, Zhou J, Chan JFW, Yuen KY, Chen H, Chen Z. Natural Transmission of Bat- like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine- Arginine-Alanine Variants in Coronavirus Disease 2019 Patients. Clin Infect Dis. 2021 Jul 15;73(2):e437-e444. doi: 10.1093/cid/ciaa953. PMID: 32649739; PMCID: PMC7454488.

150: Zhang Q, Ju B, Ge J, Chan JF, Cheng L, Wang R, Huang W, Fang M, Chen P, Zhou B, Song S, Shan S, Yan B, Zhang S, Ge X, Yu J, Zhao J, Wang H, Liu L, Lv Q, Fu L, Shi X, Yuen KY, Liu L, Wang Y, Chen Z, Zhang L, Wang X, Zhang Z. Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun. 2021 Jul 9;12(1):4210. doi: 10.1038/s41467-021-24514-w. PMID: 34244522; PMCID: PMC8270942.

151: Martín-Sánchez M, Lim WW, Yeung A, Adam DC, Ali ST, Lau EHY, Wu P, Yuen KY, Leung GM, Cowling BJ. COVID-19 transmission in Hong Kong despite universal masking. J Infect. 2021 Jul;83(1):92-95. doi: 10.1016/j.jinf.2021.04.019. Epub 2021 Apr 22. PMID: 33895227; PMCID: PMC8061183.

152: To KK, Chan WM, Ip JD, Chu AW, Tam AR, Liu R, Wu AK, Lung KC, Tsang OT, Lau DP, To WK, Kwan MY, Yau YS, Ng AC, Yip CC, Chan KH, Tse H, Hung IF, Yuen KY. Unique Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 Causing a Large Coronavirus Disease 2019 Outbreak in Hong Kong. Clin Infect Dis. 2021 Jul 1;73(1):137-142. doi: 10.1093/cid/ciaa1119. PMID: 32756996; PMCID: PMC7454385.

153: Chu H, Shuai H, Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity. Sci Adv. 2021 Jun 16;7(25):eabf8577. doi: 10.1126/sciadv.abf8577. PMID: 34134991; PMCID: PMC8208716.

154: Zhang AJ, Lee AC, Chan JF, Liu F, Li C, Chen Y, Chu H, Lau SY, Wang P, Chan CC, Poon VK, Yuan S, To KK, Chen H, Yuen KY. Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters. Clin Infect Dis. 2021 Jun 15;72(12):e978-e992. doi: 10.1093/cid/ciaa1747. PMID: 33216851; PMCID: PMC7717201.

155: Chung TW, Zhang H, Wong FK, Sridhar S, Chan KH, Cheng VC, Yuen KY, Hung IF, Mak HK. Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction. Brain Sci. 2021 May 23;11(6):686. doi: 10.3390/brainsci11060686. PMID: 34071007; PMCID: PMC8224593.

156: To KK, Hung IF, Chan KH, Yuan S, To WK, Tsang DN, Cheng VC, Chen Z, Kok KH, Yuen KY. Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection. Clin Infect Dis. 2021 May 18;72(10):e659-e662. doi: 10.1093/cid/ciaa1368. PMID: 32966566; PMCID: PMC7543314.

157: Wang P, Lau SY, Deng S, Chen P, Mok BW, Zhang AJ, Lee AC, Chan KH, Tam RC, Xu H, Zhou R, Song W, Liu L, To KK, Chan JF, Chen Z, Yuen KY, Chen H. Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein. Nat Commun. 2021 May 13;12(1):2790. doi: 10.1038/s41467-021-23166-0. PMID: 33986286; PMCID: PMC8119425.

158: Chua GT, Wong JSC, Lam I, Ho PPK, Chan WH, Yau FYS, Rosa Duque JS, Ho ACC, Siu KK, Cheung TWY, Lam DSY, Chan VCM, Lee KP, Tsui KW, Wong TW, Yau MM, Yau TY, Chan KCC, Yu MWL, Chow CK, Chiu WK, Chan KC, Wong WHS, Ho MHK, Tso WWY, Tung KTS, Wong CS, Kwok J, Leung WH, Yam JC, Wong ICK, Tam PKH, Chan GCF, Chow CB, To KKW, Lau YL, Yuen KY, Ip P, Kwan MYW. Clinical Characteristics and Transmission of COVID-19 in Children and Youths During 3 Waves of Outbreaks in Hong Kong. JAMA Netw Open. 2021 May 3;4(5):e218824. doi: 10.1001/jamanetworkopen.2021.8824. PMID: 33938934; PMCID: PMC8094012.

159: Chan WM, Ip JD, Chu AW, Tse H, Tam AR, Li X, Kwan MY, Yau YS, Leung WS, Chik TS, To WK, Ng AC, Yip CC, Poon RW, Chan KH, Wong SC, Choi GK, Lung DC, Cheng VC, Hung IF, Yuen KY, To KK. Phylogenomic analysis of COVID-19 summer and winter outbreaks in Hong Kong: An observational study. Lancet Reg Health West Pac. 2021 May;10:100130. doi: 10.1016/j.lanwpc.2021.100130. Epub 2021 Mar 23. PMID: 33778795; PMCID: PMC7985010.

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166: Li X, Chan JF, Li KK, Tso EY, Yip CC, Sridhar S, Chung TW, Chiu KH, Hung DL, Wu AK, Chau SK, Liu R, Lung KC, Tam AR, Cheng VC, To KK, Chan KH, Hung IF, Yuen KY. Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms. Infection. 2021 Apr;49(2):257-265. doi: 10.1007/s15010-020-01524-2. Epub 2020 Sep 17. PMID: 32944840; PMCID: PMC7497856.

167: Zhao H, To KKW, Lam H, Zhou X, Chan JF, Peng Z, Lee ACY, Cai J, Chan WM, Ip JD, Chan CC, Yeung ML, Zhang AJ, Chu AWH, Jiang S, Yuen KY. Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2. Nat Commun. 2021 Mar 9;12(1):1517. doi: 10.1038/s41467-021-21825-w. PMID: 33750821; PMCID: PMC7943568.

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170: Wong SC, Lam GK, AuYeung CH, Chan VW, Wong NL, So SY, Chen JH, Hung IF, Chan JF, Yuen KY, Cheng VC. Absence of nosocomial influenza and respiratory syncytial virus infection in the coronavirus disease 2019 (COVID-19) era: Implication of universal masking in hospitals. Infect Control Hosp Epidemiol. 2021 Feb;42(2):218-221. doi: 10.1017/ice.2020.425. Epub 2020 Aug 17. PMID: 32799965; PMCID: PMC7468684.

171: Lau SKP, Fan RYY, Zhu L, Li KSM, Wong ACP, Luk HKH, Wong EYM, Lam CSF, Lo GCS, Fung J, He Z, Fok FCH, Au-Yeung RKH, Zhang L, Kok KH, Yuen KY, Woo PCY. Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice. Nat Commun. 2021 Jan 11;12(1):216. doi: 10.1038/s41467-020-20458-9. PMID: 33431849; PMCID: PMC7801609.

172: Chu H, Hu B, Huang X, Chai Y, Zhou D, Wang Y, Shuai H, Yang D, Hou Y, Zhang X, Yuen TT, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Chan IH, Sit KY, Foo DC, Wong IY, Ng AT, Cheung TT, Law SY, Au WK, Brindley MA, Chen Z, Kok KH, Chan JF, Yuen KY. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung. Nat Commun. 2021 Jan 8;12(1):134. doi: 10.1038/s41467-020-20457-w. PMID: 33420022; PMCID: PMC7794309.

173: Chu H, Chan JF, Wang Y, Yuen TT, Chai Y, Shuai H, Yang D, Hu B, Huang X, Zhang X, Hou Y, Cai JP, Zhang AJ, Zhou J, Yuan S, To KK, Hung IF, Cheung TT, Ng AT, Hau-Yee Chan I, Wong IY, Law SY, Foo DC, Leung WK, Yuen KY. SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19. Cell Mol Gastroenterol Hepatol. 2021;11(3):771-781. doi: 10.1016/j.jcmgh.2020.09.017. Epub 2020 Oct 1. PMID: 33010495; PMCID: PMC7527315.

174: Lu L, Fong CH, Zhang AJ, Wu WL, Li IC, Lee AC, Dissanayake TK, Chen L, Hung IF, Chan KH, Chu H, Kok KH, Yuen KY, To KK. Repurposing of Miltefosine as an Adjuvant for Influenza Vaccine. Vaccines (Basel). 2020 Dec 11;8(4):754. doi: 10.3390/vaccines8040754. PMID: 33322574; PMCID: PMC7768360.

175: Chan JF, Zhang AJ, Yuan S, Poon VK, Chan CC, Lee AC, Chan WM, Fan Z, Tsoi HW, Wen L, Liang R, Cao J, Chen Y, Tang K, Luo C, Cai JP, Kok KH, Chu H, Chan KH, Sridhar S, Chen Z, Chen H, To KK, Yuen KY. Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility. Clin Infect Dis. 2020 Dec 3;71(9):2428-2446. doi: 10.1093/cid/ciaa325. PMID: 32215622; PMCID: PMC7184405.

176: Lam JY, Yuen CK, Ip JD, Wong WM, To KK, Yuen KY, Kok KH. Loss of orf3b in the circulating SARS-CoV-2 strains. Emerg Microbes Infect. 2020 Dec;9(1):2685-2696. doi: 10.1080/22221751.2020.1852892. PMID: 33205709; PMCID: PMC7782295.

177: Li C, Chu H, Liu X, Chiu MC, Zhao X, Wang D, Wei Y, Hou Y, Shuai H, Cai J, Chan JF, Zhou J, Yuen KY. Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target. Emerg Microbes Infect. 2020 Dec;9(1):2663-2672. doi: 10.1080/22221751.2020.1850183. PMID: 33179566; PMCID: PMC7751432.

178: Ma BM, Hung IFN, Chan GCW, Tam AR, Chan SSK, Wong BCK, Fukuda K, Ohno T, Yuen KY, Chan TM. Case of “relapsing” COVID-19 in a kidney transplant recipient. Nephrology (Carlton). 2020 Dec;25(12):933-936. doi: 10.1111/nep.13786. Epub 2020 Sep 28. PMID: 32951300; PMCID: PMC7536982.

179: Lim CY, Bohn MK, Lippi G, Ferrari M, Loh TP, Yuen KY, Adeli K, Horvath AR; IFCC Task Force on COVID-19. Staff rostering, split team arrangement, social distancing (physical distancing) and use of personal protective equipment to minimize risk of workplace transmission during the COVID-19 pandemic: A simulation study. Clin Biochem. 2020 Dec;86:15-22. doi: 10.1016/j.clinbiochem.2020.09.003. Epub 2020 Sep 12. PMID: 32926883; PMCID: PMC7486214.

180: Liu L, To KK, Chan KH, Wong YC, Zhou R, Kwan KY, Fong CH, Chen LL, Choi CY, Lu L, Tsang OT, Leung WS, To WK, Hung IF, Yuen KY, Chen Z. High neutralizing antibody titer in intensive care unit patients with COVID-19. Emerg Microbes Infect. 2020 Dec;9(1):1664-1670. doi: 10.1080/22221751.2020.1791738. PMID: 32618497; PMCID: PMC7473321.

181: Yuen CK, Lam JY, Wong WM, Mak LF, Wang X, Chu H, Cai JP, Jin DY, To KK, Chan JF, Yuen KY, Kok KH. SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists. Emerg Microbes Infect. 2020 Dec;9(1):1418-1428. doi: 10.1080/22221751.2020.1780953. PMID: 32529952; PMCID: PMC7473193.

182: Chen JH, Yip CC, Poon RW, Chan KH, Cheng VC, Hung IF, Chan JF, Yuen KY, To KK. Evaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2. Emerg Microbes Infect. 2020 Dec;9(1):1356-1359. doi: 10.1080/22221751.2020.1775133. PMID: 32459137; PMCID: PMC7448919.

183: Lau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H. Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction. Emerg Microbes Infect. 2020 Dec;9(1):837-842. doi: 10.1080/22221751.2020.1756700. PMID: 32301390; PMCID: PMC7241555.

184: Zhang X, Chu H, Wen L, Shuai H, Yang D, Wang Y, Hou Y, Zhu Z, Yuan S, Yin F, Chan JF, Yuen KY. Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation. Emerg Microbes Infect. 2020 Dec;9(1):733-746. doi: 10.1080/22221751.2020.1738277. PMID: 32223537; PMCID: PMC7170352.

185: Chan JF, Yuan S, Zhang AJ, Poon VK, Chan CC, Lee AC, Fan Z, Li C, Liang R, Cao J, Tang K, Luo C, Cheng VC, Cai JP, Chu H, Chan KH, To KK, Sridhar S, Yuen KY. Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2020 Nov 19;71(16):2139-2149. doi: 10.1093/cid/ciaa644. PMID: 32472679; PMCID: PMC7314229.

186: Hung IF, Yuen KY. Early triple antiviral therapy for COVID-19 – Authors’ reply. Lancet. 2020 Nov 7;396(10261):1488. doi: 10.1016/S0140-6736(20)32268-6. PMID: 33160568; PMCID: PMC7832612.

187: Yuan S, Wang R, Chan JF, Zhang AJ, Cheng T, Chik KK, Ye ZW, Wang S, Lee AC, Jin L, Li H, Jin DY, Yuen KY, Sun H. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Nov;5(11):1439-1448. doi: 10.1038/s41564-020-00802-x. Epub 2020 Oct 7. PMID: 33028965.

188: To KK, Chua GT, Kwok KL, Wong JS, Au DCY, Lam YY, Wong WH, Ho MH, Chan GC, Chui CS, Li X, Tung KT, Wong RS, Tso WW, Wong IC, Wong CS, Fong CH, Chan KH, Yuen KY, Ip P, Kwan MY. False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease. Diagn Microbiol Infect Dis. 2020 Nov;98(3):115141. doi: 10.1016/j.diagmicrobio.2020.115141. Epub 2020 Jul 17. PMID: 32795776; PMCID: PMC7366972.

189: Cheng VC, Wong SC, Chan VW, So SY, Chen JH, Yip CC, Chan KH, Chu H, Chung TW, Sridhar S, To KK, Chan JF, Hung IF, Ho PL, Yuen KY. Air and environmental sampling for SARS-CoV-2 around hospitalized patients with coronavirus disease 2019 (COVID-19). Infect Control Hosp Epidemiol. 2020 Nov;41(11):1258-1265. doi: 10.1017/ice.2020.282. Epub 2020 Jun 8. PMID: 32507114; PMCID: PMC7327164.

190: Chan WM, Ip JD, Chu AW, Yip CC, Lo LS, Chan KH, Ng AC, Poon RW, To WK, Tsang OT, Leung WS, Kwan MY, Chua GT, Chung TW, Hung IF, Kok KH, Cheng VC, Chan JF, Yuen KY, To KK. Identification of nsp1 gene as the target of SARS-CoV-2 real-time RT-PCR using nanopore whole-genome sequencing. J Med Virol. 2020 Nov;92(11):2725-2734. doi: 10.1002/jmv.26140. Epub 2020 Jun 19. PMID: 32501535; PMCID: PMC7300711.

191: Wang X, Lam JY, Wong WM, Yuen CK, Cai JP, Au SW, Chan JF, To KKW, Kok KH, Yuen KY. Accurate Diagnosis of COVID-19 by a Novel Immunogenic Secreted SARS- CoV-2 orf8 Protein. mBio. 2020 Oct 20;11(5):e02431-20. doi: 10.1128/mBio.02431-20. PMID: 33082264; PMCID: PMC7587431.

192: Lee AC, Zhang AJ, Chan JF, Li C, Fan Z, Liu F, Chen Y, Liang R, Sridhar S, Cai JP, Poon VK, Chan CC, To KK, Yuan S, Zhou J, Chu H, Yuen KY. Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters. Cell Rep Med. 2020 Oct 20;1(7):100121. doi: 10.1016/j.xcrm.2020.100121. Epub 2020 Sep 22. PMID: 32984855; PMCID: PMC7508015.

193: Zhou R, To KK, Wong YC, Liu L, Zhou B, Li X, Huang H, Mo Y, Luk TY, Lau TT, Yeung P, Chan WM, Wu AK, Lung KC, Tsang OT, Leung WS, Hung IF, Yuen KY, Chen Z. Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses. Immunity. 2020 Oct 13;53(4):864-877.e5. doi: 10.1016/j.immuni.2020.07.026. Epub 2020 Aug 4. PMID: 32791036; PMCID: PMC7402670.

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198: Zhang BZ, Chu H, Han S, Shuai H, Deng J, Hu YF, Gong HR, Lee AC, Zou Z, Yau T, Wu W, Hung IF, Chan JF, Yuen KY, Huang JD. SARS-CoV-2 infects human neural progenitor cells and brain organoids. Cell Res. 2020 Oct;30(10):928-931. doi: 10.1038/s41422-020-0390-x. Epub 2020 Aug 4. PMID: 32753756; PMCID: PMC7399356.

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200: Shuai H, Chu H, Hou Y, Yang D, Wang Y, Hu B, Huang X, Zhang X, Chai Y, Cai JP, Chan JF, Yuen KY. Differential immune activation profile of SARS-CoV-2 and SARS-CoV infection in human lung and intestinal cells: Implications for treatment with IFN-β and IFN inducer. J Infect. 2020 Oct;81(4):e1-e10. doi: 10.1016/j.jinf.2020.07.016. Epub 2020 Jul 21. PMID: 32707230; PMCID: PMC7373021.

201: Chan KH, Sridhar S, Zhang RR, Chu H, Fung AY, Chan G, Chan JF, To KK, Hung IF, Cheng VC, Yuen KY. Factors affecting stability and infectivity of SARS- CoV-2. J Hosp Infect. 2020 Oct;106(2):226-231. doi: 10.1016/j.jhin.2020.07.009. Epub 2020 Jul 9. PMID: 32652214; PMCID: PMC7343644.

202: Wong LR, Ye ZW, Lui PY, Zheng X, Yuan S, Zhu L, Fung SY, Yuen KS, Siu KL, Yeung ML, Cai Z, Woo PC, Yuen KY, Chan CP, Jin DY. Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein Suppresses Type I IFN Expression by Impeding HSP70-Dependent Activation of IRF3 Kinase IKKε. J Immunol. 2020 Sep 15;205(6):1564-1579. doi: 10.4049/jimmunol.1901489. Epub 2020 Aug 3. PMID: 32747502; PMCID: PMC9202338.

203: Chan JF, To KK, Yuen KY. A Case Series of Children With Coronavirus Disease 2019: What Have We Learned? Clin Infect Dis. 2020 Sep 12;71(6):1552-1553. doi: 10.1093/cid/ciaa469. PMID: 32318718; PMCID: PMC7188164.

204: Chu H, Chan JF, Wang Y, Yuen TT, Chai Y, Hou Y, Shuai H, Yang D, Hu B, Huang X, Zhang X, Cai JP, Zhou J, Yuan S, Kok KH, To KK, Chan IH, Zhang AJ, Sit KY, Au WK, Yuen KY. Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19. Clin Infect Dis. 2020 Sep 12;71(6):1400-1409. doi: 10.1093/cid/ciaa410. PMID: 32270184; PMCID: PMC7184390.

205: Fong CH, Cai JP, Dissanayake TK, Chen LL, Choi CY, Wong LH, Ng AC, Pang PKP, Ho DT, Poon RW, Chung TW, Sridhar S, Chan KH, Chan JF, Hung IF, Yuen KY, To KK. Improved Detection of Antibodies against SARS-CoV-2 by Microsphere-Based Antibody Assay. Int J Mol Sci. 2020 Sep 9;21(18):6595. doi: 10.3390/ijms21186595. PMID: 32916926; PMCID: PMC7555114.

206: Hung IF, Cheng VC, Li X, Tam AR, Hung DL, Chiu KH, Yip CC, Cai JP, Ho DT, Wong SC, Leung SS, Chu MY, Tang MO, Chen JH, Poon RW, Fung AY, Zhang RR, Yan EY, Chen LL, Choi CY, Leung KH, Chung TW, Lam SH, Lam TP, Chan JF, Chan KH, Wu TC, Ho PL, Chan JW, Lau CS, To KK, Yuen KY. SARS-CoV-2 shedding and seroconversion among passengers quarantined after disembarking a cruise ship: a case series. Lancet Infect Dis. 2020 Sep;20(9):1051-1060. doi: 10.1016/S1473-3099(20)30364-9. Epub 2020 Jun 12. PMID: 32539986; PMCID: PMC7292581.

207: Yuan S, Chan JFW, Chik KKH, Chan CCY, Tsang JOL, Liang R, Cao J, Tang K, Chen LL, Wen K, Cai JP, Ye ZW, Lu G, Chu H, Jin DY, Yuen KY. Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system. Pharmacol Res. 2020 Sep;159:104960. doi: 10.1016/j.phrs.2020.104960. Epub 2020 May 28. PMID: 32473310; PMCID: PMC7254006.

208: Yuan S, Chu H, Huang J, Zhao X, Ye ZW, Lai PM, Wen L, Cai JP, Mo Y, Cao J, Liang R, Poon VK, Sze KH, Zhou J, To KK, Chen Z, Chen H, Jin DY, Chan JF, Yuen KY. Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target. Sci Adv. 2020 Aug 28;6(35):eaba7910. doi: 10.1126/sciadv.aba7910. PMID: 32923629; PMCID: PMC7455044.

209: Zhao H, To KKW, Sze KH, Yung TT, Bian M, Lam H, Yeung ML, Li C, Chu H, Yuen KY. A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. Nat Commun. 2020 Aug 25;11(1):4252. doi: 10.1038/s41467-020-17986-9. PMID: 32843628; PMCID: PMC7447754.

210: Yip CC, Sridhar S, Leung KH, Ng AC, Chan KH, Chan JF, Tsang OT, Hung IF, Cheng VC, Yuen KY, To KK. Development and Evaluation of Novel and Highly Sensitive Single-Tube Nested Real-Time RT-PCR Assays for SARS-CoV-2 Detection. Int J Mol Sci. 2020 Aug 7;21(16):5674. doi: 10.3390/ijms21165674. PMID: 32784770; PMCID: PMC7461039.

211: Yang D, Chu H, Hou Y, Chai Y, Shuai H, Lee AC, Zhang X, Wang Y, Hu B, Huang X, Yuen TT, Cai JP, Zhou J, Yuan S, Zhang AJ, Chan JF, Yuen KY. Attenuated Interferon and Proinflammatory Response in SARS-CoV-2-Infected Human Dendritic Cells Is Associated With Viral Antagonism of STAT1 Phosphorylation. J Infect Dis. 2020 Aug 4;222(5):734-745. doi: 10.1093/infdis/jiaa356. PMID: 32563187; PMCID: PMC7337793.

212: To KK, Yuen KY. Seroprevalence of SARS-CoV-2 in Hong Kong returnees – Authors’ reply. Lancet Microbe. 2020 Aug;1(4):e148. doi: 10.1016/S2666-5247(20)30092-6. Epub 2020 Aug 6. PMID: 33521714; PMCID: PMC7834862.

213: Liu L, Wang P, Nair MS, Yu J, Rapp M, Wang Q, Luo Y, Chan JF, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, Chen Z, Yuen KY, Kwong PD, Sodroski JG, Yin MT, Sheng Z, Huang Y, Shapiro L, Ho DD. Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike. Nature. 2020 Aug;584(7821):450-456. doi: 10.1038/s41586-020-2571-7. Epub 2020 Jul 22. PMID: 32698192.

214: Chu AW, Chan WM, Ip JD, Yip CC, Chan JF, Yuen KY, To KK. Evaluation of simple nucleic acid extraction methods for the detection of SARS-CoV-2 in nasopharyngeal and saliva specimens during global shortage of extraction kits. J Clin Virol. 2020 Aug;129:104519. doi: 10.1016/j.jcv.2020.104519. Epub 2020 Jun 23. PMID: 32629187; PMCID: PMC7309780.

215: Zhang BZ, Hu YF, Chen LL, Yau T, Tong YG, Hu JC, Cai JP, Chan KH, Dou Y, Deng J, Wang XL, Hung IF, To KK, Yuen KY, Huang JD. Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients. Cell Res. 2020 Aug;30(8):702-704. doi: 10.1038/s41422-020-0366-x. Epub 2020 Jul 1. PMID: 32612199; PMCID: PMC7327194.

216: Yip CC, Sridhar S, Cheng AK, Leung KH, Choi GK, Chen JH, Poon RW, Chan KH, Wu AK, Chan HS, Chau SK, Chung TW, To KK, Tsang OT, Hung IF, Cheng VC, Yuen KY, Chan JF. Evaluation of the commercially available LightMix® Modular E-gene kit using clinical and proficiency testing specimens for SARS-CoV-2 detection. J Clin Virol. 2020 Aug;129:104476. doi: 10.1016/j.jcv.2020.104476. Epub 2020 May 27. PMID: 32516739; PMCID: PMC7255195.

217: Cheng VCC, Wong SC, Chuang VWM, So SYC, Chen JHK, Sridhar S, To KKW, Chan JFW, Hung IFN, Ho PL, Yuen KY. Absence of nosocomial transmission of coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in the prepandemic phase in Hong Kong. Am J Infect Control. 2020 Aug;48(8):890-896. doi: 10.1016/j.ajic.2020.05.018. Epub 2020 May 24. PMID: 32461068; PMCID: PMC7246012.

218: Wong SC, AuYeung CH, Lam GK, Leung EY, Chan VW, Yuen KY, Cheng VC. Is it possible to achieve 100 percent hand hygiene compliance during the coronavirus disease 2019 (COVID-19) pandemic? J Hosp Infect. 2020 Aug;105(4):779-781. doi: 10.1016/j.jhin.2020.05.016. Epub 2020 May 15. PMID: 32422309; PMCID: PMC7255117.

219: Chan KH, Yuen KY. COVID-19 epidemic: disentangling the re-emerging controversy about medical facemasks from an epidemiological perspective. Int J Epidemiol. 2020 Aug 1;49(4):1063-1066. doi: 10.1093/ije/dyaa044. Erratum in: Int J Epidemiol. 2020 Oct 1;49(5):1760. PMID: 32232402; PMCID: PMC7184463.

220: To KK, Tsang OT, Yip CC, Chan KH, Wu TC, Chan JM, Leung WS, Chik TS, Choi CY, Kandamby DH, Lung DC, Tam AR, Poon RW, Fung AY, Hung IF, Cheng VC, Chan JF, Yuen KY. Consistent Detection of 2019 Novel Coronavirus in Saliva. Clin Infect Dis. 2020 Jul 28;71(15):841-843. doi: 10.1093/cid/ciaa149. PMID: 32047895; PMCID: PMC7108139.

221: Chen JH, Yip CC, Chan JF, Poon RW, To KK, Chan KH, Cheng VC, Yuen KY. Clinical Performance of the Luminex NxTAG CoV Extended Panel for SARS-CoV-2 Detection in Nasopharyngeal Specimens from COVID-19 Patients in Hong Kong. J Clin Microbiol. 2020 Jul 23;58(8):e00936-20. doi: 10.1128/JCM.00936-20. PMID: 32482633; PMCID: PMC7383549.

222: To KK, Cheng VC, Cai JP, Chan KH, Chen LL, Wong LH, Choi CY, Fong CH, Ng AC, Lu L, Luo CT, Situ J, Chung TW, Wong SC, Kwan GS, Sridhar S, Chan JF, Fan CY, Chuang VWM, Kok KH, Hung IF, Yuen KY. Seroprevalence of SARS-CoV-2 in Hong Kong and in residents evacuated from Hubei province, China: a multicohort study. Lancet Microbe. 2020 Jul;1(3):e111-e118. doi: 10.1016/S2666-5247(20)30053-7. Epub 2020 Jun 3. PMID: 33230504; PMCID: PMC7673299.

223: Zhou J, Li C, Liu X, Chiu MC, Zhao X, Wang D, Wei Y, Lee A, Zhang AJ, Chu H, Cai JP, Yip CC, Chan IH, Wong KK, Tsang OT, Chan KH, Chan JF, To KK, Chen H, Yuen KY. Infection of bat and human intestinal organoids by SARS-CoV-2. Nat Med. 2020 Jul;26(7):1077-1083. doi: 10.1038/s41591-020-0912-6. Epub 2020 May 13. PMID: 32405028.

224: Cheng VC, Wong SC, Chuang VW, So SY, Chen JH, Sridhar S, To KK, Chan JF, Hung IF, Ho PL, Yuen KY. The role of community-wide wearing of face mask for control of coronavirus disease 2019 (COVID-19) epidemic due to SARS-CoV-2. J Infect. 2020 Jul;81(1):107-114. doi: 10.1016/j.jinf.2020.04.024. Epub 2020 Apr 23. PMID: 32335167; PMCID: PMC7177146.

225: Cheung KS, Hung IFN, Chan PPY, Lung KC, Tso E, Liu R, Ng YY, Chu MY, Chung TWH, Tam AR, Yip CCY, Leung KH, Fung AY, Zhang RR, Lin Y, Cheng HM, Zhang AJX, To KKW, Chan KH, Yuen KY, Leung WK. Gastrointestinal Manifestations of SARS- CoV-2 Infection and Virus Load in Fecal Samples From a Hong Kong Cohort: Systematic Review and Meta-analysis. Gastroenterology. 2020 Jul;159(1):81-95. doi: 10.1053/j.gastro.2020.03.065. Epub 2020 Apr 3. PMID: 32251668; PMCID: PMC7194936.

226: Yuan S, Chan CC, Chik KK, Tsang JO, Liang R, Cao J, Tang K, Cai JP, Ye ZW, Yin F, To KK, Chu H, Jin DY, Hung IF, Yuen KY, Chan JF. Broad-Spectrum Host- Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19). Viruses. 2020 Jun 10;12(6):628. doi: 10.3390/v12060628. PMID: 32532085; PMCID: PMC7354423.

227: Hung DL, Li X, Chiu KH, Yip CC, To KK, Chan JF, Sridhar S, Chung TW, Lung KC, Liu RW, Kwan GS, Hung IF, Cheng VC, Yuen KY. Early-Morning vs Spot Posterior Oropharyngeal Saliva for Diagnosis of SARS-CoV-2 Infection: Implication of Timing of Specimen Collection for Community-Wide Screening. Open Forum Infect Dis. 2020 Jun 7;7(6):ofaa210. doi: 10.1093/ofid/ofaa210. PMID: 32577428; PMCID: PMC7299521.

228: Chung TW, Sridhar S, Zhang AJ, Chan KH, Li HL, Wong FK, Ng MY, Tsang RK, Lee AC, Fan Z, Ho RS, Luk SY, Kan WK, Lam SH, Wu AK, Leung SM, Chan WM, Ng PY, To KK, Cheng VC, Lung KC, Hung IF, Yuen KY. Olfactory Dysfunction in Coronavirus Disease 2019 Patients: Observational Cohort Study and Systematic Review. Open Forum Infect Dis. 2020 Jun 5;7(6):ofaa199. doi: 10.1093/ofid/ofaa199. PMID: 32548209; PMCID: PMC7284010.

229: To KKW, Yuen KY. Responding to COVID-19 in Hong Kong. Hong Kong Med J. 2020 Jun;26(3):164-166. doi: 10.12809/hkmj205101. Epub 2020 Jun 11. PMID: 32525099.

230: Cheng VCC, Wong SC, Kwan GSW, Hui WT, Yuen KY. Disinfection of N95 respirators by ionized hydrogen peroxide during pandemic coronavirus disease 2019 (COVID-19) due to SARS-CoV-2. J Hosp Infect. 2020 Jun;105(2):358-359. doi: 10.1016/j.jhin.2020.04.003. Epub 2020 Apr 8. PMID: 32277965; PMCID: PMC7194585.

231: Hung IF, Lung KC, Tso EY, Liu R, Chung TW, Chu MY, Ng YY, Lo J, Chan J, Tam AR, Shum HP, Chan V, Wu AK, Sin KM, Leung WS, Law WL, Lung DC, Sin S, Yeung P, Yip CC, Zhang RR, Fung AY, Yan EY, Leung KH, Ip JD, Chu AW, Chan WM, Ng AC, Lee R, Fung K, Yeung A, Wu TC, Chan JW, Yan WW, Chan WM, Chan JF, Lie AK, Tsang OT, Cheng VC, Que TL, Lau CS, Chan KH, To KK, Yuen KY. Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet. 2020 May 30;395(10238):1695-1704. doi: 10.1016/S0140-6736(20)31042-4. Epub 2020 May 10. PMID: 32401715; PMCID: PMC7211500.

232: Wang Q, Zhang Y, Wu L, Niu S, Song C, Zhang Z, Lu G, Qiao C, Hu Y, Yuen KY, Wang Q, Zhou H, Yan J, Qi J. Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. Cell. 2020 May 14;181(4):894-904.e9. doi: 10.1016/j.cell.2020.03.045. Epub 2020 Apr 9. PMID: 32275855; PMCID: PMC7144619.

233: Chu H, Chan JF, Yuen TT, Shuai H, Yuan S, Wang Y, Hu B, Yip CC, Tsang JO, Huang X, Chai Y, Yang D, Hou Y, Chik KK, Zhang X, Fung AY, Tsoi HW, Cai JP, Chan WM, Ip JD, Chu AW, Zhou J, Lung DC, Kok KH, To KK, Tsang OT, Chan KH, Yuen KY. Comparative tropism, replication kinetics, and cell damage profiling of SARS- CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study. Lancet Microbe. 2020 May;1(1):e14-e23. doi: 10.1016/S2666-5247(20)30004-5. Epub 2020 Apr 21. PMID: 32835326; PMCID: PMC7173822.

234: Cheng VC, Wong SC, Yuen KY. Estimating Coronavirus Disease 2019 Infection Risk in Health Care Workers. JAMA Netw Open. 2020 May 1;3(5):e209687. doi: 10.1001/jamanetworkopen.2020.9687. PMID: 32437571.

235: To KK, Tsang OT, Leung WS, Tam AR, Wu TC, Lung DC, Yip CC, Cai JP, Chan JM, Chik TS, Lau DP, Choi CY, Chen LL, Chan WM, Chan KH, Ip JD, Ng AC, Poon RW, Luo CT, Cheng VC, Chan JF, Hung IF, Chen Z, Chen H, Yuen KY. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect Dis. 2020 May;20(5):565-574. doi: 10.1016/S1473-3099(20)30196-1. Epub 2020 Mar 23. PMID: 32213337; PMCID: PMC7158907.

236: Cheng VCC, Wong SC, Chen JHK, Yip CCY, Chuang VWM, Tsang OTY, Sridhar S, Chan JFW, Ho PL, Yuen KY. Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID-19) due to SARS- CoV-2 in Hong Kong. Infect Control Hosp Epidemiol. 2020 May;41(5):493-498. doi: 10.1017/ice.2020.58. Epub 2020 Mar 5. PMID: 32131908; PMCID: PMC7137535.

237: Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS; China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28. PMID: 32109013; PMCID: PMC7092819.

238: Chan JF, Yip CC, To KK, Tang TH, Wong SC, Leung KH, Fung AY, Ng AC, Zou Z, Tsoi HW, Choi GK, Tam AR, Cheng VC, Chan KH, Tsang OT, Yuen KY. Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated <i>In Vitro</i> and with Clinical Specimens. J Clin Microbiol. 2020 Apr 23;58(5):e00310-20. doi: 10.1128/JCM.00310-20. PMID: 32132196; PMCID: PMC7180250.

239: Yip CC, Ho CC, Chan JF, To KK, Chan HS, Wong SC, Leung KH, Fung AY, Ng AC, Zou Z, Tam AR, Chung TW, Chan KH, Hung IF, Cheng VC, Tsang OT, Tsui SKW, Yuen KY. Development of a Novel, Genome Subtraction-Derived, SARS-CoV-2-Specific COVID-19-nsp2 Real-Time RT-PCR Assay and Its Evaluation Using Clinical Specimens. Int J Mol Sci. 2020 Apr 8;21(7):2574. doi: 10.3390/ijms21072574. PMID: 32276333; PMCID: PMC7177594.

240: Wu Y, Ho W, Huang Y, Jin DY, Li S, Liu SL, Liu X, Qiu J, Sang Y, Wang Q, Yuen KY, Zheng ZM. SARS-CoV-2 is an appropriate name for the new coronavirus. Lancet. 2020 Mar 21;395(10228):949-950. doi: 10.1016/S0140-6736(20)30557-2. Epub 2020 Mar 6. PMID: 32151324; PMCID: PMC7133598.

241: Cheng VCC, Wong SC, To KKW, Ho PL, Yuen KY. Preparedness and proactive infection control measures against the emerging novel coronavirus in China. J Hosp Infect. 2020 Mar;104(3):254-255. doi: 10.1016/j.jhin.2020.01.010. Epub 2020 Jan 18. PMID: 31962139; PMCID: PMC7134450.

242: Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, Liu J, Yip CC, Poon RW, Tsoi HW, Lo SK, Chan KH, Poon VK, Chan WM, Ip JD, Cai JP, Cheng VC, Chen H, Hui CK, Yuen KY. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020 Feb 15;395(10223):514-523. doi: 10.1016/S0140-6736(20)30154-9. Epub 2020 Jan 24. PMID: 31986261; PMCID: PMC7159286.

243: Ng MY, Lee EYP, Yang J, Yang F, Li X, Wang H, Lui MM, Lo CS, Leung B, Khong PL, Hui CK, Yuen KY, Kuo MD. Imaging Profile of the COVID-19 Infection: Radiologic Findings and Literature Review. Radiol Cardiothorac Imaging. 2020 Feb 13;2(1):e200034. doi: 10.1148/ryct.2020200034. PMID: 33778547; PMCID: PMC7233595.

244: Zhao X, Chu H, Wong BH, Chiu MC, Wang D, Li C, Liu X, Yang D, Poon VK, Cai J, Chan JF, To KK, Zhou J, Yuen KY. Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages. J Infect Dis. 2020 Feb 3;221(4):647-659. doi: 10.1093/infdis/jiz483. PMID: 31562757; PMCID: PMC7107474.

245: Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020 Jan 28;9(1):221-236. doi: 10.1080/22221751.2020.1719902. Erratum in: Emerg Microbes Infect. 2020 Dec;9(1):540. PMID: 31987001; PMCID: PMC7067204.

246: Lau SKP, Li KSM, Luk HKH, He Z, Teng JLL, Yuen KY, Wernery U, Woo PCY. Middle East Respiratory Syndrome Coronavirus Antibodies in Bactrian and Hybrid Camels from Dubai. mSphere. 2020 Jan 22;5(1):e00898-19. doi: 10.1128/mSphere.00898-19. PMID: 31969478; PMCID: PMC6977179.