Dr. MOK Wing Yee, Bobo

PhD in Infection Biology (Karolinska Institute)

Scientific Officer

Email: bobomok@hku.hk

ORCID: https://orcid.org/0000-0003-3187-2736


Dr. Mok obtained her PhD in Infection Biology from the Karolinska Institute in Sweden under the supervision of Professor Mat Wahlgren in 2007. During her doctoral studies, she focused on transcriptomic and genomic analyses of Plasmodium falciparum, the deadliest species of Plasmodium responsible for causing malaria in humans. Upon completing her PhD, Dr. Mok returned to Hong Kong and joined the Department of Microbiology under the esteemed mentorship of Professor Chen Honglin. Since 2020, Dr. Mok has been serving as a Scientific Officer, overseeing various research projects in Professor Chen’s group. She aims to inspire future generations of scientists and medical professionals through her dedication and expertise.

research focus

  1. Investigating the roles of nuclear NS1 in influenza.
  2. Exploring epigenetic regulation in response to RNA virus infections.
  3. Examining RNA granules and their association with cellular responses to RNA virus challenges.

selected publications

  1. Ho JSY*, Mok BW*, Campisi L et al., TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. Cell. 2021 May 13;184(10):2618-2632.e17. doi: 10.1016/j.cell.2021.03.051 (*These authors contributed equally to this work)
  2. Lu L*Mok BW*, Chen LL*, Chan JM, Tsang OT, Lam BH, Chuang VW, Chu AW, Chan WM, Ip JD, Chan BP, Zhang R, Yip CC, Cheng VC, Chan KH, Jin DY, Hung IF, Yuen KY, Chen H, To KK. Neutralization of SARS-CoV-2 Omicron variant by sera from BNT162b2 or Coronavac vaccine recipients. Clin Infect Dis. 2021 Dec 16:ciab1041. doi: 10.1093/cid/ciab1041. (*These authors contributed equally to this work)
  3. Mok BW, Liu H, Deng S, Liu J, Zhang AJ, Lau SY, Liu S, Tam RC, Cremin CJ, Ng TT, Leung JS, Lee LK, Wang P, To KK, Chan JF, Chan KH, Yuen KY, Siu GK, Chen H.  Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters. Commun Biol. 2021 Sep 20;4(1):1102. doi: 10.1038/s42003-021-02640-x.
  4. Lau SY*, Wang P*Mok BW*, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H. Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction. Emerg Microbes Infect. 2020 Dec;9(1):837-842.  (*These authors contributed equally to this work) 
  5. Meng F, Siu GK, Mok BW, Sun J, Fung KSC, Lam JY, Wong NK, Gedefaw L, Luo S, Lee TMH, Yip SP, Huang CL.  Viral MicroRNAs Encoded by Nucleocapsid Gene of SARS-CoV-2 Are Detected during Infection, and Targeting Metabolic Pathways in Host Cells. Cells. 2021 Jul 12;10(7):1762. doi: 10.3390/cells10071762.
  6. Liu YC, Mok BW, Wang P, Kuo RL, Chen H, Shih SR. Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication. 2021 Aug 31;12(4):e0094521. doi: 10.1128/mBio.00945-21.
  7. Liu S, Mok BW, Wang P, Chen P, Huang X, Zheng M, Liu H, Cremin CJ, Lau SY, , Li B, Jiang L, Chen Y, Song WJ, Yuen KY and Chen H. PB2 host adaptation evades host autophagic antiviral response for influenza virus replication. Cell Rep. 2021 Jun 8;35(10):109213. doi: 10.1016/j.celrep.2021.109213.
  8. Mok BWLiu H, Chen P, Liu S, Lau SY, Huang X, Liu YC, Wang P, Yuen KY, Chen H. 2017. The role of nuclear NS1 protein in highly pathogenic H5N1 influenza viruses. Microbes Infect. 2017 Dec;19(12):587-596
  9. Wen X, Huang X, Mok BW, Chen Y, Zheng M, Lau SY, Wang P, Song W, Jin DY, Yuen KY, Chen H. NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. J Immunol. 2014 Apr 15;1
  10. Mok BW, Song W, Wang P, Tai H, Chen Y, Zheng M, Wen X, Lau SY, Wu WL, Matsumoto K, Yuen KY, Chen H. The NS1 protein of influenza A virus interacts with cellular processing bodies (P-bodies) and stress granules through RNA-associated protein 55 (RAP55) during virus infection. J Virol. 2012 Dec 86(23): 12695-707.
  11. Mok BW, Ribacke U, Rasti N, Kironde F, Chen Q, Nilsson P, Wahlgren M. Default Pathway of var2csa switching and translational repression in Plasmodium falciparum. PLoS ONE. 2008 Apr 23;3(4):e1982.
  12. Mok BW, Ribacke U, Sherwood E, Wahlgren M. A highly conserved segmental duplication in the subtelomeres of Plasmodium falciparum chromosomes varies in copy number. Malar J. 2008 Mar 7;7:46.
  13. Ribacke U, Mok BW, Wirta V, Normark J, Lundeberg J, Kironde F, Egwang TG, Nilsson P, Wahlgren M. Genome wide gene amplifications and deletions in Plasmodium falciparum. Mol Biochem Parasitol. 2007 Sep;155(1):33-44.
  14. Mok BW, Ribacke U, Winter G, Yip BH, Tan CS, Fernandez V, Chen Q, Nilsson P, Wahlgren M. Comparative transcriptomal analysis of isogenic Plasmodium falciparum clones of distinct antigenic and adhesive phenotypes. Mol Biochem Parasitol. 2007 Feb;151(2):184-92.
  15. Donati D, Mok BW, Chêne A, Xu H, Thangarajh M, Glas R, Chen Q, Wahlgren M, Bejarano MT. Increased B cell survival and preferential activation of the memory compartment by a malaria polyclonal B cell activator. J Immunol. 2006 Sep 1;177(5):3035-44.
  16. Mok BW, Yeung WS, Luk JM. Differential expression of gap-junction gene connexin 31 in seminiferous epithelium of rat testes. FEBS Lett. 1999 Jun 25;453(3):243-8.