Prof. CHEN Zhiwei

DVM (Northwestern Agricultural University), MSc (New Mexico State University), PhD (New York University)

Director and Tenured Chair Professor
AIDS Institute, Department of Microbiology, School of Clinical Medicine Li Ka Shing Faculty of Medicine, The University of Hong Kong

ORCID : https://orcid.org/0000-0002-4511-2888

HKU Scholars Hub: https://hub.hku.hk/cris/rp/rp00243

Tel: (852) 3917 9831; Fax: 3917 9095

Email: zchenai@hku.hk

Education

DVM. (Sept. 1980 – July 1985), Veterinary Medicine, College of Veterinary Medicine, Northwestern Agricultural University, Shaanxi, P.R. of China

M.Sc. (Sept. 1991 – May 1993), Biology and Molecular Biology, Department of Biology, New Mexico State University, USA (Mentor: Professor Preston A. Marx)

Ph.D. (Jan. 1994 – May 1996), Microbiology, Department of Microbiology, New York University Medical Center, New York University, USA (Mentor: Professor Preston A. Marx)

professrional experience

2023 – present Director and Tenured Chair Professor; AIDS Institute, Department of Microbiology, School of Clinical Medicine, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR

2014 – 2023 Director and Tenured Full Professor; AIDS Institute, Department of Microbiology, School of Clinical Medicine, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR

2007 – 2014 Director and Tenure-track Associate Professor, AIDS  Institute,  Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR

2002 – 2007 Guest Professor and Ph.D. Advisor, State Key Laboratory of Virology of China, Modern Virology Research Center and AIDS Center, College of Life Sciences, Wuhan University, China

2002 – 2007 Staff Investigator and Assistant Professor, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, USA

1999 – 2002 Research Scientist, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, USA (Mentor: Professor David D. Ho)

1996 – 1999 Postdoctoral Fellow, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, USA (Mentor: Professor David D. Ho)

Honours/Awards/other Esteemed Factors

  1. Charles H. Revson/Norman and Rosita Winston Fellow 1998
  2. US NIH F32 Fellow 1998-2002
  3. Clinical Infectious Diseases Award for Outstanding Review 2010
  4. JAIDS Outstanding Reviewer Award 2015
  5. China New Development Award 2019 (Springer Nature)
  6. Faculty Knowledge Exchange Award 2018-19 (HKUMed)
  7. Knowledge Exchange Excellence Award 2019 (HKU)
  8. Outstanding Researcher Award 2020-21 (HKU)
  9. Outstanding Research Student Supervisor Award 2020-21 (HKU)
  10. Gold Medal in Inventions Geneva Evaluation 2021
  11. Faculty Outstanding Research Output Award 2021 (HKUMed)
  12. Most Picked Award – 2021 Chinese Scientists with Cell Press (Cell Press)
  13. Bronze Medal in Inventions Geneva Evaluation 2022
  14. Faculty Outstanding Research Output Award 2022 (HKUMed)
  15. Ranked by Clarivate Analytics as the top 1% worldwide by citations and one of HKU academics among Highly Cited Researchers 2022
  16. Conferment of the title of Chair Professor by the president of The University of Hong Kong 2023
  17. Faculty Outstanding Research Output Award 2023 (HKUMed)
  18. Ranked by Clarivate Analytics as the top 1% worldwide by citations and one of HKU academics among Highly Cited Researchers 2023

Academic Editor and Editorial Board Member

  1. Immunotherapy Advances, Founding Editorial Board Member, since 2020; Publisher: Oxford University Press, invited by British Society for Immunology
  2. AIDS: Member of Editorial Board, since Jan 2017; Publisher: Lippincott Williams & Wilkins, USA
  3. Journal of Acquired Immune Deficiency Syndromes (JAIDS); Member of Editorial Board, since Jan 2010; Publisher: Lippincott Williams & Wilkins, USA
  4. Journal of Neuroimmune Pharmacology (JNIP); the peer-reviewed journal of the Society on NeuroImmune Pharmacology. Publisher: Springer
  5. Journal of Leukocyte Biology, Guest editor, 2020
  6. Current Opinion in HIV and AIDS, Invited guest editor for the November Issue 2020 on COVID-19, together with the invited Editorial
  7. Journal of Medical Primatology, Member of Editorial Board, since 2008; Publisher: Blackwell-Wiley InterScience
  8. PLoS ONE, Academic Editor and Member of Editorial Board since 2010; Publisher: Public Library of Science, USA
  9. Journal of Antivirals and Antiretrovirals (Editor/Member of Editorial Board, since 2009); Publisher: OMICS Publishing Group
  10. Faculty Member of F1000, F1000 Faculty comprises the world’s leading researchers across all of biology and medicine

Organizing or Scientific Committee for International Conferences on HIV/AIDS

  1. 2014 Scientific Committee Member, 20th International AIDS Conference, Melbourne, by International AIDS Society
  2. 2015 Scientific Advisory Board, Cent Gardes Conference: HIV Vaccines, France
  3. 2016 Scientific Committee Member, Asia-pacific AIDS & Co-Infection Conference
  4. 2017 Scientific Committee Member, Asia-pacific AIDS & Co-Infection Conference
  5. 2018 Section chair at The HIV Research for Prevention (HIVR4P) international conference in Madrid
  6. 2018 Scientific Committee Member, Asia-pacific AIDS & Co-Infection Conference
  7. 2019 Invited Speaker, Cent Gardes Conference: HIV Vaccines, France
  8. 2020 Invited plenary speaker at the Asia-Pacific AIDS & Co-Infections Conference 2020 in Thailand
  9. 2020 Scientific Committee Member, Asia-pacific AIDS & Co-Infection Conference
  10. 2020 Section Chair and Plenary Speaker, 5th International Conference & Expo on HIV & AIDS, the HIV-AIDS Summit 2020, Philadelphia, USA
  11. 2022 Scientific Committee Member, Asia-pacific AIDS & Co-Infection Conference
  12. IAS 2023: World’s largest scientific conference on HIV (Brisbane) by International AIDS Society, Abstract Selection Panel
  13. IAS 2023, Invited Speaker, 2023 HIV Cure & Immunotherapy Forum; Section Chair for Advances in gene delivery and engineering of T and B cells: Implications for prevention, therapy and cure, Brisbane, Australia
  14. AIDS 2024, basic research scientific committee member and reviewer, Munich, Germany
    1.  

Reviewer for domestic and international grant applications

  1. Hong Kong Health and Medical Fund (HMRF)
  2. National Natural Science Foundation of China
  3. Science, Technology and Innovation Commission of Shenzhen Municipality
  4. American Foundation for AIDS Research (amFAR)
  5. The Bill & Melinda Gates Foundation
  6. Netherlands Organization for Scientific Research
  7. British St Stephen’s AIDS Trust

Professional Services at HKU and Local Community

  1. Director, AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong; July 2007 – present
  2. Council member, Hong Kong Society for Immunology; Term: 2015 – present
  3. Chairman, Hong Kong Society for Immunology; Term: 2018 – 2020
  4. Member, Faculty BBMS Organizing Committee and Curriculum Committee; Term: 2015 – 2020
  5. Member, Faculty High Degree Committee; Term: 2016 – 2019
  6. Member, Advisory Council on AIDS, Department of Health, HKSAR; Term: 2008 – 2014
  7. Board Director, Friends of Hope Education Fund, Hong Kong SAR; Term: 2008 – 2019; Initiated the AIDS orphan educational program, honorary board member
  8. Board Director, AIDS Concern, Hong Kong SAR; Term: 2013 –
  9. Board Director, Hong Kong AIDS Foundation, Hong Kong SAR; Term: 2019 – present; to promote HIV education and preventions programs
  10. Member of Biology Panel, University Grants Committee, HKSAR; May 2024
  11. Founding professor, Research Pandemic Alliance (RPA), Global; 2024

The American Society and Association Membership

  1. The American Society for Microbiology
  2. The American Association of Immunologists
  3. American Society on NeuroImmune Pharmacology
  4. International AIDS Society

Professional Services at HKU and Local Community

  1. Director, AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong; July 2007 – present
  2. Council member, Hong Kong Society for Immunology; Term: 2015 – present
  3. Chairman, Hong Kong Society for Immunology; Term: 2018 – 2020
  4. Member, Faculty BBMS Organizing Committee and Curriculum Committee; Term: 2015 – 2020
  5. Member, Faculty High Degree Committee; Term: 2016 – 2019
  6. Member, Advisory Council on AIDS, Department of Health, HKSAR; Term: 2008 – 2014
  7. Board Director, Friends of Hope Education Fund, Hong Kong SAR; Term: 2008 – 2019; Initiated the AIDS orphan educational program, honorary board member
  8. Board Director, AIDS Concern, Hong Kong SAR; Term: 2013 –
  9. Board Director, Hong Kong AIDS Foundation, Hong Kong SAR; Term: 2019 – present; to promote HIV education and preventions programs
  10. Member of Biology Panel, University Grants Committee, HKSAR; May 2024
  11. Founding professor, Research Pandemic Alliance (RPA), Global; 2024

Reviewer for peer-reviewed international journals

AIDS, JAIDS, Immunity, Science Translational Medicine, Lancet Infectious Disease, Lancet HIV, Journal of Virology, Journal of Clinical Investigation, Journal of Experimental Medicine, Emerging Microbes & Infections, Virology, Clinical Infectious Diseases, Journal of Infectious Diseases, Clinical Chemistry, Journal of Virological Methods, PLoS One, Journal of Immunology, Applied Microbiology and Biotechnology, Viruses, etc.

Fellowship, Awards and Grants in the USA

1998-1999 Fellowship award from the Charles H. Revson/Norman and Rosita Winston Foundation, The Rockefeller University. Role: Principal Investigator

1998-2002 Grant funded by National Institutes of Health (NIH/NIAID, 1F32AI 10256), Characterization of a CCR2-tropic recombinant simian immunodeficiency virus; Role: Principal Investigator

2000-2001 Grant funded by the American Foundation for AIDS Research (amFAR, 02663-27-RGM); Development of a Novel SHIV/Macaque Model for Microbicide Testing; Role: Principal Investigator

2005-2009 Grant from National Institutes of Health, USA; (NIH RO1 HL080211-01); A Novel Model for the Study of Lung Pathogenesis of SARS; Role: Principal Investigator

External Grants Received from the USA for Research at HKU

2007-2009 Grant from National Institutes of Health, USA; (NIH 5 R01 HL080211-03); US$2.4 million; A Novel Model for the Study of Lung Pathogenesis of SARS; Role: Principal Investigator

2007-2011 Grant from National Institutes of Health, USA; (NIH  3  R01 DA020419-02S1); Cannabinoid effects on HIV/AIDS; Role: Co-Principal Investigator

2008-2009 Grant BMGF 52117, Bill & Melinda Gates Foundation; Preventing HIV-1 infection using a novel vaccine immunogen; Role: Principal Investigator

2017-2021 Grant from Bill & Melinda Gates Foundation for the National Institutes of Health (AR170035), USA; Structure-Based Vaccine Design against HIV-1, Role: Co-Principal Investigator

External Grant Received from the UK for Research at HKU

2020 – 2022 Grant from Wellcome Trust (the Funder) for project entitled “A comprehensive study of immunopathogenesis of SARS-CoV-2 infection”, Role: Co-Principal Investigator

External Grant Received from the Coalition for Epidemic Preparedness Innovations (CEPI) for COVID-19 Vaccine Research at HKU

2020 – 2020    Phase I, Role: Co-Principal Investigator

2020 – 2022    Phase II, Role: Co-Principal Investigator

External Awards and Grants Received from Australia for Research at HKU

2020 – 2022 Grant from Australian MRFF 2020 COVID-19 Vaccine Candidate Grant Opportunity for project entitled “A safe, effective, and rapidly tuneable SARS-CoV-2 vaccine”, Role: Co-Investigator

External Awards and Grants Received in Hong Kong as PI

2008-2009       Grant RGC-GRF 762208M, HKSAR;      Mucosal vaccine against HIV-1 infection; Role: Principal Investigator

2008-2009       Understanding the Ongoing HIV Epidemic in Yunnan China; Supported by China AIDS Initiative (Hong Kong Committee); Role: Principal Investigator

2009-2012       Grant RGC-GRF 762209M, HKSAR; Role of the PD-1/PD-L pathway in AIDS vaccine design; Role: Principal Investigator

2010-2012 Grant RFCID 09080772, HKSAR; Characterization of novel anti-HIV/TB natural product analogues; Role: Principal Investigator

2011-2013 AIDS Trust Fund (ATF) MSS 183 R, HKSAR; Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system; Role: Principal Investigator

2011-2013 Pneumoconiosis Compensation Fund Board (PCFB), HKSAR; A Novel Vaccine for Mesothelioma Immunotherapy and Prevention; Role: Principal Investigator

2011-2013 Grant RFCID 11101022, HKSAR, A Novel Vaccine for Tuberculosis Prevention; Role: Principal Investigator

2012-2014 Grant RGC-GRF 762811M, HKSAR; A Promising Mucosal Prime and Intramuscular Boost AIDS Vaccine Regimen; Role: Principal Investigator

2012-2015       Grant RGC-NSFC N_HKU 709/11, HKSAR; HIV prevention using gene-encoded neutralizing antibodies; HK$892,290; Role: Principal Investigator

2013-2015       Grant Information Technology Fund (ITF) GHX/013/11SZ, HK$682,642. Phenotypic Assay for HIV drug resistance; Role: Principal Investigator

2013-2016       Grant RGC-GRF 762712, HKSAR; Mechanism of soluble PD-1 based vaccine in amplifying antiviral CD8+ T-cell immunity; Role: Principal Investigator

2014-2016 Grant ITF ITS/194/13, HKSAR; A New Therapeutic Vaccine for HIV/AIDS; Role: Principal Investigator

2014-2017       Grant RGC-CRF HKU5/CRF/13G, HKSAR; Mechanism of potentiating HIV antigen-specific CD8+ T cells; Role: Project Coordinator

2014-2017       Grant ATF MSS 227R, HKSAR; The level of GFAP as a specific biomarker of neuroAIDS among Chinese patients; Role: Principal Investigator

2015-2016       Grant PCFB, HKSAR; Induction of Mesothelioma-Specific CD8+ T cells Response for Immunotherapy and Prevention; Role: Principal Investigator

2015-2019 Grant RGC-ANR A-HKU709/14, HKSAR; A novel DNA-based vaccination strategy to mimic Gag• specific responses found in HIV Elite Controllers; Role: Principal Investigator

2015-2017 Grant RGC-GRF 17103514, HKSAR; Role of a newly identified PD-1 isoform in modulating immune responses; Role: Principal Investigator

2015-2017 Grant HMRF 14130582, HKSAR; Role of Delta 42PD-1 in HIV Infection; Role: Principal Investigator

2016-2018 Grant RGC-GRF 17122915, HKSAR; Role of PD-1 Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression; Role: Principal Investigator

2017-2018 Grant PCFB, HKSAR; Induction of Mesothelioma-Specific CD8+ T cells Response for Immunotherapy and Prevention; Role: Principal Investigator

2018-2019 Grant ITF ITS/170/17, HKSAR; A Novel Therapeutic AAV-vectored Bi-Specific Neutralizing Antibody against HIV/AIDS; Role: Principal Investigator

2018-2019 Grant ITF UIM/314, HKSAR; A novel PD1-based vaccine for HIV/AIDS Immunotherapy; Role: Principal Investigator

2018-2019 Grant PCFB, HKSAR; Enhancing immunotherapeutic efficacy of mesothelioma by overcoming MDSC-mediated immunosuppression; Role: Principal Investigator

2018-2021 Industry Contract Research, A Humanized anti-d42PD1 antibody against human inflammatory disease and cancer; Role: Principal Investigator

2019-2021 Grant RGC-GRF 17115818, HKSAR; Role of Δ42PD-1 in Human Dendritic Cells during HIV-1 Infection; Role: Principal Investigator

2019-2021 Grant HMRF 18170762, HKSAR; HIV-1 mucosal prevention and immunotherapy by engineered tandem bi-specific IgA; Role: Principal Investigator

2019-2023 Grant RGC-TRS T11-706/18-N, HKSAR; Potentiating Host Immunity for HIV-1 Functional Cure; Role: Project Co-ordinator

2020-2022 Grant RGC-GRF 17104919, HKSAR; Mechanism of a Δ42PD-1-specific humanized antibody huCH101 in treating HIV/AIDS; Role: Principal Investigator

2021-2023 Grant RGC-GRF 17121420, HKSAR; Combined BiIA-SG and

anti-TRABD2A antibody for HIV-1 Functional Cure; Role: Principal Investigator

2021-2024 Grant RGC-CRF C7156-20G, HKSAR; Mechanism of Immune Control against COVID-19; Role: Project Coordinator

2022-2025 Grant RGC-GRF 17117422, HKSAR; Mechanism of vaccine-induced mucosal immune responses against SARS-CoV-2 infection; Role: Principal Investigator

2023-2026 Grant RGC-GRF 1711923, HKSAR; Role of HIV-1-specific antibodies cloned from Δ42PD-1 positive memory B cells; Role: Principal Investigator

2024-2029  Grant ITC- RAISe+ RA1/23/072A, HKSAR; Research and development of the lead Δ42PD1 antibody drug as an immunotherapy against cancers and infections: Person-in-charge

External Awards and Grants Received in Hong Kong as Co-PI

2015-2018 Grant RGC-CRF C7038-14G, HKSAR; Investigation of  effects  and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma; Role: Co-Principal Investigator

2017-2020 Grant from Sanming Project (AR160087); Study on AIDS Vaccine and Immunotherapy; Role: Project Leader

2019-2022 Grant RGC-CRF C4045-18W,  HKSAR;  Deciphering Enhancer Regulation of Tumor Immune Evasion to Develop New Combination Immunotherapies; Role: Co-Principal Investigator

2020-2022 HMRF Commissioned Research (COVID190123); “Clinical study of flu-based

and PD1-based vaccines for the SARS-CoV-2”; HK$10 million; Role: Co-Principal investigator

2020-2025 Grant RGC-TRS T12-703/19-R, HKSAR; Fighting Disease Recurrence and Promoting Tissue Repair after Liver Transplantation: Translating Basic Discoveries to Clinical Excellence; Role: Co-Principal Investigator

2020-2025 InnoHK “Centre for Virology, Vaccinology and Therapeutics”,  HKSAR; Role: Project Co-Principal Investigator

2021-2024     Grant RGC-CRF C1134-20G, HKSAR;  A novel vaccination strategy: using a microrobot platform for DNA vaccine delivery and antigen presentation; Role: Co-Principal Investigator

2022-2026 Grant RGC-TRS T11-709/21-N, HKSAR; Ecology, Molecular Virology and Pathogenesis of SARS-CoV-2: From Bedside to Bench and Back; Role: Co-Principal Investigator

External Awards and Grants Received for Research in Mainland China

2006-2010 Chinese 973 Research Program on HIV/AIDS; Role: Project 8 Leader

2008-2010 Grant from the China Ministry of Health; Novel AIDS mucosal vaccine (2008ZX10001-011); Role: Project Leader

2008-2010 Grant from the China Ministry of Health; (2008ZX10001-015); Microbicide against HIV; Role: Project Leader

2012-2015 Grant from the China Ministry of Health; Novel AIDS mucosal vaccine (China’s Major Project of the National Science & Technology 2012ZX10001-009); Role: Project 1 Leader

2013-2016 Grant from the China Ministry of Health; Novel Anti-HIV Antibody for Prevention (China’s Major Project of the National Science & Technology 2017ZX10201101-004); Role: Project 4 Leader

2020-2022 Grant from the Shenzhen Government at HKU SZH; PD1-based COVID-19 vaccine (ICCOV); JSGG20200225151410198; Role: Principal Investigator

2020-2022 Sub-grant from the Ministry of Science and Technology at HKU SZH; Mechanism of antibody-enhanced SARS-CoV-2 infection; 2020YFC0860600; Role: Co-Investigator

2022-2023 Grant from the Shenzhen Government at HKU SZH; Development portable Raman instrument for COVID disease detection; JSGG220220606141800002; Role: Co-Investigator

Peer-reviewed International Publications: (*Corresponding author)

  1. Chen Z, Telfer P, Reed P, Zhang L, Getti A, Ho DD and Marx Isolation and characterization of the first simian immunodeficiency virus from a feral sooty mangabey (Cercocebus atys) in West Africa. Journal of Medical Primatology. 24:108-115, 1995.
  2. Chen Z, Telfer P, Gettie A, Reed P, Zhang L, Ho DD and Marx 1996. Genetic characterization of new West African simian immunodeficiency virus SIVsm: geographic clustering of household-derived SIV strains with human immunodeficiency virus type 2 subtypes and genetically diverse viruses from a single feral sooty mangabey troop. Journal of Virology. 70:3617-3627, 1996.
  3. Chen Z, Luckay A, Sodora DL, Telfer P, Reed P, Gettie A, Kanu JM, Sadek RF, Yee J, Ho DD, Zhang L and Marx PA. Human immunodeficiency virus type 2 (HIV-2) seroprevalence and characterization of a distinct HIV-2 genetic subtype from the natural range of simian immunodeficiency virus  infected  sooty  mangabeys. Journal of Virology. 71:3953-3960, 1997.
  1. Chen Z,  Zhou P,  Ho DD, Landau NR and Marx   Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. Journal of Virology. 71:2705-2714, 1997.
  2. Georges-Courbot MC, Lu CY, Makuwa M, Telfer P, Onanga R, Dubreil, Chen Z, Smith SM, Georges A and Marx Natural Infection of a Household Pet Red-Capped Mangabey (Cercocebus torquatus torquatus) with a New Simian Immunodeficiency Virus. Journal of Virology. 72:600-8, 1998.
  3. Chen Z, Gettie A, Ho DD and Marx Primary SIVsm isolates use the CCR5 co-receptor from sooty mangabeys naturally infected in West Africa: a comparison of coreceptor usage of primary SIVsm, HIV-2 and SIVmac. Virology. 246:113-124, 1998.
  4. Marx PA and Chen Z. The function of simian chemokine receptors in the  replication of Seminars in Immunology. (Invited review article) 10:215-223, 1998.
  5. Zhang L, He T, Huang Y, Chen Z, Guo Y, Wu S, Kunstman KJ, Brown RC, Phair JP, Neumann AU, Ho DD, Wolinsky Chemokine coreceptor usage by diverse primary isolates of human immunodeficiency virus type 1. Journal of Virology. Nov; 72(11):9307-12, 1998. (IF: 5.402; Cited: 142.)
  6. Palacios E, Digilio L, McClure HM, Chen Z, Marx PA, Goldsmith MA and Grant RM. Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus. Current Biology. Jul 30-Aug 13;8(16):943-6,
  7. Chen Z, Kwon D, Jin Z , Monard S, Telfer P, Jones MS, Aguilar R, Ho DD and Marx Natural infection of a homozygous deleted CCR5 red-capped mangabey with a CCR2b-tropic simian immunodeficiency virus. Journal of Experimental Medicine. Dec 7;188(11):2057-65, 1998.
  8. Chen Z, Huang Y, Zhao X, Skulsky E, Lin D, Ip J, Gettie A and Ho DD. Enhanced infectivity of an R5-tropic simian/human immunodeficiency virus carrying human immunodeficiency virus type 1 subtype C envelope after serial passages in pig-tailed macaques (Macaca nemestrina). Journal of Virology. 74:6501-10,
  9. Chen Z, Zhao X, Huang Y, Huang YL, Gettie A, Ba L, Blanchard J and Ho DD. CD4+ Lymphocytopenia in Acute Infection of Asian Macaques by a Vaginally Transmissible Subtype-C, CCR5-Tropic Simian/Human Immunodeficiency Virus (SHIV). Journal of Acquired Immune Deficiency Syndromes. 30:133-145,
  10. Lue J, Hsu M, Yang D, Marx P, Chen Z, and Cheng-Mayer C. Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1. Journal of Virology. Oct;76(20):10299-306,
  11. Pohlmann S, Zhang J, Baribaud F, Chen Z, Leslie GJ, Lin G, Granelli-Piperno A, Doms RW, Rice CM, McKeating JA. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. Journal of Virology. Apr;77(7):4070-80,
  12. Zhuang K, Gui X, Su B, Tien P, Chen Z, Zhang L. High prevalence of HIV  infection among women and their children in Henan Province, China. Journal of Acquired Immune Deficiency Syndromes. 33(5):649-50. 2003.
  13. Su B, Liu L, Wang F, Gui X, Zhao M, Tien P, Zhang L and Chen Z*.  HIV-1 subtype B’ dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China. AIDS. 21;17(17):2515-20. 2003.
  14. Wu Z, Chen Z, Phillips DM. Human genital epithelial cells  capture  cell-free human immunodeficiency virus type 1 and transmit the virus to CD4+ Cells: implications for mechanisms of sexual transmission. The Journal of Infectious Diseases. 188(10):1473-82. 2003.
  15. Kao RY, Tsui WH, Lee TS, Tanner JA, Watt RM, Huang JD, Hu L, Chen G, Chen Z, Zhang L, He T, Chan KH, Tse H, To AP, Ng LW, Wong BC, Tsoi HW, Yang D, Ho DD, Yuen KY. Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics. Chemistry & Biology. 2004 Sep;11(9):1293-9.
  16. Zhang L, Chen Z, Cao Y, Yu J, Li G, Yu W, Yin N, Mei S, Li L, Balfe P, He T, Ba L, Zhang F, Lin HH, Yuen MF, Lai CL, Ho DD. Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in China. Journal of Virology. 78(24):13591-9. 2004. (Shared the first author)
  17. Chen Z, Zhang L, Qin C, Ba L, Yi CE, Zhang F, Wei Q, He T, Yu W, Yu J, Gao H, Tu X, Gettie A, Farzan M, Yuen KY, Ho DD. Recombinant modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region. Journal of Virology. 79(5):2678-88. 2005.
  18. Fang Q, Yang L, Zhu W, Liu L, Wang H, Yu W, Xiao G, Tien P, Zhang L, Chen Z*. Host range, growth property, and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain. Virology. 10;335(2):242-51. 2005.
  19. Yi CE, Ba L, Zhang L, Ho DD, Chen Z*. Single amino acid substitutions in the severe acute respiratory syndrome coronavirus spike glycoprotein determine viral entry and immunogenicity of a major neutralizing domain. Journal of Virology. Sep;79(18):11638-46. 2005.
  20. Woo PC, Lau SK, Tsoi HW, Chen Z, Wong BH, Zhang L, Chan JK, Wong LP, He W, Ma C, Chan KH, Ho DD, Yuen KY. SARS coronavirus spike polypeptide DNA vaccine priming with recombinant spike polypeptide from Escherichia coli as booster induces high titer of neutralizing antibody against SARS coronavirus. Vaccine. Oct 10;23(42):4959-4968. 2005.
  21. Liu L, Su B, Zhuang K, Tien P, Chen Z, Zhang L. Genetic Characterization of Full-Length HIV Type 1 Genomes From 3 Infected Paid Blood Donors in Henan, China. Journal of Acquired Immune Deficiency Syndromes. 2005 Dec 1;40(4):501-503.
  22. Chen Z, Zhu W, Fang Q, Zhuang K, Yu W, Wang H, Liu L, Tien P and Zhang L. Construction and characterization of a novel replication competent vaccinia Tiantan-based vector for vaccine development. Antiviral Therapy. 11(S2):171-172. 2006.
  1. Chen Z, Fang Q, Zhuang K, Yu W, Zhu W, Wang H, Liu L, Tien P, Ho DD and Zhang L. A novel mucosal vaccinia vector for inducing high-level anti-viral immunity. Antiviral Therapy. 11(S2): 70-71. 2006.
  2. Chen Z, Zhang Y, Lu L, Ba L, Yang L, Jia MH, Shi Y, Yan W, Chang G, Zhang L and Ho DD. A comprehensive molecular epidemiology study of HIV-1 subtypes in Yunnan Province of China. Antiviral Therapy. 11(S2):120-121. 2006.
  3. Zhang L, Zhang F, Yu W, He T, Yu J, Yi CE, Ba L, Li W, Farzan M, Chen Z, Yuen KY, Ho D. Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals. Journal of Medical Virology. Jan;78(1):1-8. 2006.
  4. Lin H-H, Gaschen BK, Collie M, EL-Fishaway M, Chen Z, Korber BT, Beatrice ST, Zhang L. Genetic Characterization of Human Immunodeficiency Virus Type I (HIV-1) Strains in an Immigrant Population Living in New York City. Journal of Acquired Immune Deficiency Syndromes. 2006 Apr 1;41(4):399-404..
  5. Gardiner DF, Huang Y, Basu S, Leung L, Song Y, Chen Z, Ho DD. Multiple-site DNA vaccination enhances immune responses in mice. Vaccine. 2006 Jan 16;24(3):287-92. Epub 2005 Aug 8.
  6. Pohlmann S, Munch J, Aziz S, Reeves JD, Otto C, Leslie GJ, Hofmann H, Puffer BA, Baribaud F, Marzi A, Gramberg T, Chen Z, Stolte N, Haaft PT, Heeney JL, Stahl-Hennig C, Matz-Rensing K, Schneider T, Doms RW, Kirchhoff F. A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo. Virology. 2007 Apr 10;360(2):275-85.
  7. Zhang Y, Lu L, Ba L, Liu L, Yang L, Jia M, Wang H, Fang Q, Shi Y, Yan W, Chang G, Zhang L, Ho DD, Chen Z*. Dominance of HIV-1 subtype CRF01_AE in sexually acquired cases leads to a new epidemic in Yunnan province of China. PLoS Medicine. 2006 Nov;3(11):e443.
  8. Liu L, Fang Q, Deng F, Wang H, Yi C, Ba L, Yu W, Lin RD, Li T, Hu ZH, Ho DD, Zhang L, Chen Z*. Natural mutations in the receptor binding domain of spike glycoprotein determine the reactivity of cross-neutralization between palm civet coronavirus and severe acute respiratory syndrome coronavirus. Journal of Virology. 2007. May;81(9):4694-700.
  9. Li T, Xie J, He Y, Fan H, Baril L, Qiu Z, Han Y, Xu W, Zhang W, You H, Zuo Y, Fang Q, Yu J, Chen Z, Zhang L. Long-term persistence of robust antibody and cytotoxic T cell responses in recovered patients infected with SARS coronavirus. PLoS ONE. 2006 Dec 20;1:e24.
  10. Ma D, Yu S, Li B, Chen L, Chen R, Yu K, Zhang L, Chen Z, Zhong D, Gong Z, Wang R, Jiang H, Pei G. Synthesis and Biological Evaluation of 1,3,3,4-Tetrasubstituted Pyrrolidine CCR5 Receptor Antagonists. Discovery of a Potent and Orally Bioavailable Anti-HIV Agent. ChemMedChem. 2007 Feb 12;2(2):187-193.
  11. Zhu W, Fang Q, Liu L, Wang H, Zhou J, Yu W, Tien P, Zhang L, Chen Z*. The attenuation of vaccinia Tian Tan strain by the removal of the viral M1L-K2L genes. Journal of Virological Methods. 2007 Sep;144(1-2):17-26.
  12. Ba L, Yi CE, Zhang L, Ho DD, Chen Z*. Heterologous MVA-S prime Ad5-S boost regimen induces high and persistent levels of neutralizing antibody response against SARS coronavirus. Applied Microbiology and Biotechnology. 2007 Oct;76(5):1131-6.
  13. Ma T, Gao Q, Chen Z, Wang L, Liu G. Chemical resolution of ()-calanolide A, ()-cordatolide A and their 11-demethyl analogues. Bioorganic & Medicinal Chemistry Letters. 2008 Feb 1;18(3):1079-83.
  14. Ma T, Liu L, Xue H, Li L, Han C, Wang L, Chen Z, Liu G. Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents. Journal of Medicinal Chemistry. 2008 Mar 13;51(5):1432-46.
  15. Chen Z, Huang Y, Zhao X, Ba L, Zhang W and Ho DD. Design, Construction, and Characterization of a Multigenic Modified Vaccinia Ankara Candidate Vaccine against Human Immunodeficiency Virus Type 1 Subtype C/B’. Journal of Acquired Immune Deficiency Syndromes. 2008 Apr 1;47(4):412-21.
  16. Huang Y, Chen Z, Zhang W, Song Y, Zhao X, Gardiner DF and Ho DD. Design, Construction, and Characterization of a Dual-Promoter Multigenic DNA Vaccine Directed against an HIV-1 Subtype C/B’ Recombinant. Journal of Acquired Immune Deficiency Syndromes. 2008 Apr 1;47(4):403-11.
  17. Huang Y, Chen A, Li X, Chen Z, Zhang W, Song Y, Gurner D, Gardiner D, Basu S, Ho DD, Tsuji M. Enhancement of HIV DNA vaccine immunogenicity by the NKT cell ligand, alpha-galactosylceramide. Vaccine. 2008 Mar 28;26(15):1807-16.
  18. Chen YX, Liu L, Wei Q, Zhu H, Jiang H, Tu XM, Qin C and Chen Z*. Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques. Virology. 2008 Nov 10;381(1):89-97.
  19. Lu L, Jia M, Ma Y, Yang L, Chen Z, Ho DD, Jiang Y, Zhang L. The Changing Face of HIV in China. Nature. Oct 2. 455:609-11, 2008.
  20. Luo M, Liu H, Zhuang K, Liu L, Su B, Yang R, Tien P, Zhang L, Gui X and Chen Z*. Prevalence of drug resistant HIV-1 in rural areas of Hubei province in the People’s Republic of China. Journal of Acquired Immune Deficiency Syndromes. Jan 1; 50(1): 1-8. 2009.
  21. Bian C, Zhang X, Cai X, Zhang L, Chen Z, Zha Y, Xu Y, Xu K, Lu W, Yan L, Yuan J, Feng J, Hao P, Wang Q, Zhao G, Liu G, Zhu X, Shen H, Zheng B, Shen B, Sun B. Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody. Virology. 2009 Jan 5;383(1):39-46.
  22. Huang XX, Lu B, Fang Q, Yu W, Liu L, Zhuang K, Shen TT, Wang HB, Tian P, Zhang L, and Chen Z*. A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination. PLoS ONE. 2009;4(1):e4180.
  23. Cheng S, LI J, Lin B, Lee D, Liu L, Chen Z, Lau A. HIV-1 trans-activator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN signaling. Blood. 2009 May 21;113(21):5192-201.
  24. Xu L, Zhang YF, Liu Y, Chen Z, Deng H, Ma Z, Wang H, Hu Z, and Fei Deng F. Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus. Journal of General Virology. 2009 Nov. 90:2695-2703.
  25. Chen Z, Sun C, Du Y, Chen L and Zhang L. Effective control of a pathogenic SIVmac239 challenge by a novel heterologous mucosal prime and intramuscular boost vaccine strategy. Retrovirology. 2009, 6 (S3):419.
  26. Vasan S, Schlesinger SJ, Huang Y, Hurley A, Lombardo A, Chen Z, Than S, Adesanya P, Bunce C, Boaz M, Boyle R, Sayeed E, Clark L, Dugin D, Schmidt C, Song Y, Seamons L, Dally L, Ho M, Smith C, Markowitz M, Cox J, Gill DK, Gilmour J, Keefer MC, Fast P, Ho DD. Phase 1 Safety and Immunogenicity Evaluation of ADVAX, a Multigenic, DNA-based Clade C/B’ HIV-1 Candidate Vaccine. PLoS ONE. 2010 Jan; 5(1):e8617.
  27. Vasan S, Schlesinger SJ, Chen Z, Hurley A, Lombardo A, Than S, Adesanya P, Bunce C, Boaz M, Boyle R, Sayeed E, Clark L, Dugin D, Boente-Carrera M, Schmidt C, Fang Q, LeiBa, Huang Y, Zaharatos GJ, Gardiner DF, Caskey M, Seamons L, Ho M, Dally L, Smith C, Cox J, Gill D, Gilmour J, Keefer MC, Fast P, Ho DD. Phase 1 Safety and Immunogenicity Evaluation of ADMVA, a Multigenic, Modified Vaccinia Ankara-based Clade C/B’ HIV-1 Candidate Vaccine. PLoS ONE. 2010 Jan; 5(1):e8816.
  28. Xue H, Lu XF, Zheng PR, Liu L, Han CY, Hu JP, Liu ZJ, Ma T, Li Y, Wang L, Chen Z* and Liu G*. Highly suppressing wild-type HIV-1 and Y181C Mutant HIV-1 Strains by 10-Chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile. Journal of Medicinal Chemistry. 53(3), pp1397-1401. 2010.
  29. Yu W, Fang Q, Zhu W, Wang H, Tien P, Zhang L, and Chen Z*. One time intranasal vaccination with a modified vaccinia Tiantan strain MVTT (ZCI) protects animals against pathogenic viral challenge. Vaccine. 2010 Feb 25;28(9):2088-96.
  30. Tang X and Chen Z*. The development of an AIDS mucosal vaccine. Viruses. 2010, 2(1), 283-297. (Invited review article)
  31. Wang H, Zhuang K, Liu L, Tang Z, Tang J, Tien P, Zhang L, and Chen Z*. Acute infection of Chinese macaques by a CCR5-tropic SHIV carrying a primary HIV-1 subtype B’ envelope. Journal of Acquired Immune Deficiency Syndromes. Mar 1:53(3):285-291. 2010.
  32. Liu H, Yu W, Zhu W, Wang H, and Chen Z*. The route of inoculation determines the tissue tropism of modified vaccinia Tiantan expressing the spike glycoprotein of SARS-CoV in mice. Journal of Medical Virology. 2010 May;82(5):727-34.
  33. Lu XF and Chen Z*. The development of anti-HIV drugs. ACTA Pharmaceutica Sinica. 2010. 45(2): 165-176. (Invited review article)
  34. Chen JH-K, Wong K-H, Chen Z, Chan K, Lam H-Y, et al. Increased Genetic Diversity of HIV-1 Circulating in Hong Kong. PLoS ONE. 2010. 5(8): e12198.
  35. Jiang B, Qin L, Du Y, Peng N, Chen L, Chen Z, Chen X. Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites. Vaccine. 2010 Nov 23;28(50):7915-22.
  36. Chen JH, Wong KH, Chan KC, To SW, Chen Z, Yam WC. Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong. PLoS One. 2011;6(9):e25286. Epub 2011 Sep 22.
  37. Liu L, Wei Q, Alvarez X, Wang H, Du Y, Zhu H, Jiang H, Zhou J, Lam P, Zhang L, Lackner A, Qin C, Chen Z*. Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tract of Rhesus Macaques. Journal of Virology. 2011. 85(8b):4025-4030.
  38. Lu B, Yu W, Huang XX, Wang H, Liu L, and Chen Z*. Mucosal immunization induces a higher level of lasting neutralizing antibody response in mice by a replication-competent smallpox vaccine, vaccinia Tiantan strain. Journal of Biomedicine and Biotechnology. 2011;2011:970424.
  39. Lu X, Liu L, Zhang X, Lau TC, Tsui SK, Kang Y, Zheng P, Zheng B, Liu G, Chen Z*. F18, a novel small molecule NNRTI, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis. Antimicrob Agents Chemother. 2012 Jan;56(1):341-51.
  40. Zhang Q, Zhang X, Wu H, Seto D, Zhang H-J, Chen Z, Wan CS, Zheng BJ. Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC. PLoS ONE. 2012 Feb; 7(2): e31233. doi:10.1371/journal.pone.0031233
  41. Liu Z, Li L, Chen Z, Xu M, Zhang T, Jiao Y, Sheng B, Chen D and Wu Prevalence  of GB virus type C viraemia in MSM with or without HIV-1 infection in Beijing, China. Epidemiology & Infection. 2012 Dec;140(12):2199-209.
  42. Yao X, Wang H, Yan P, Lu Y, Lin H, Chen L, Ng J, Lau E, Li L, Wu J, Chen Z*. Rising epidemic of HIV-1 infections among general populations in Fujian, China. Journal of Acquired Immune Deficiency Syndromes. 2012 Jul; 60(3): 328-35.
  43. Zhou F, Wang G, Buchy P, Cai Z, Chen H, Chen Z, Cheng G, Wan XF, Deubel V, Zhou P. A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses. Journal of Virology. 2012 Jun; 86(12): 6970-8.
  44. Qiu M, Wang Q, Chu Y, Yuan Z, Song HY, Chen Z*, and Wu Z* Lignosulfonic acid shows potent antiretroviral activity – potential as a microbicide candidate for the prevention of HIV-1 sexual transmission. PLoS One. 2012 Apr; 7(4): e35906. doi:10.1371/journal.pone.0035906
  45. Kang Y, Wu Z, Lau TC, Lu X, Liu L, Cheung AK, Tan Z, Ng J, Liang J, Wang H, Li S, Zheng B, Li B, Chen L, Chen Z*. CCR5 antagonist TD-0680 uses a novel mechanism for enhanced potency against HIV-1 entry, cell-mediated infection, and a resistant variant. The Journal of Biological Chemistry. 2012 May; 287(20):16499-509.
  46. Qiu M, Chen Y, Song S, Song H, Chu Y, Yuan Z, Cheng L, Zheng D, Chen Z, Wu Z. Poly (4-styrenesulfonic acid-co-maleic acid) is an entry inhibitor against both HIV-1 and HSV infections – potential as a dual functional microbicide. Antiviral Research. 2012 November; 96(2):138-47.
  47. Kang Y, Guo J and Chen Z*. Closing the door to human immunodeficiency virus. Protein & Cell. 2013 Feb; 4(2):86-102 (Invited Review Article)
  48. Zhou J, Cheung AKL, Tan Z, Wang H, Kang Y, Du Y, Lu X, Liu L, Yuen KY and Chen Z*. PD1-based DNA vaccine amplifies HIV-1 CD8+ T cells in mice. Journal of Clinical Investigation. 2013 Jul; 123(6):2629–2642.
  49. Sun C, Chen Z*, Tang X, Zhang Y, Feng L, Du Y, Xiao L, Liu L, Chen L, Zhang L. Mucosal Prime with a Replicating Vaccinia-based Vaccine Elicits Protective Immunity against SIV Challenge in Rhesus Monkeys. Journal of Virology. 2013 May; 87(10):5669-77. (Shared first author and corresponding author)
  50. Zhou J, Cheung AKL, Liu H, Tan Z, Tang X, Kang Y, Du Y, Wang H, Liu L, and Chen Z*. Potentiating functional antigen-specific CD8+ T cell immunity  by  a novel PD1 isoform-based fusion DNA vaccine. Molecular Therapy. 2013 Jul; 21(7):1445-55.
  51. Peng Q, Wang H, Wang H, Li X, Lu X, Zhou B, and Chen Z*. Imbalances of gut-homing CD4+ T cell subsets in HIV-1 infected Chinese patients. Journal of Acquired Immune Deficiency Syndromes. 2013 Sep; 64(1):25-31.
  52. To SW, Chen JH, Wong KH, Chan KC, Chen Z, Yam WC. Determination of the High Prevalence of Dual/Mixed- or X4-Tropism Among HIV Type 1 CRF01_AE in Hong Kong by Genotyping and Phenotyping Methods. AIDS Research and Human Retroviruses. 2013 August; 29(8):1123-8.
  53. Zhang Y, Xu J, San Q, Shao Y, Chen Z and Zhang MY. The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development. AIDS. 2013 Oct; 27(16):2529-39.
  54. Xiao H, Liu L, Zhu Q, Tan Z, Yu W, Tang X, Zhan D, Du Y, Wang H, Liu D, Li Z, Yuen KY, Ho DD, Gao GF, Chen Z*. A replicating modified vaccinia tiantan strain expressing an avian-derived influenza H5N1 hemagglutinin induce broadly neutralizing antibodies and cross-clade protective immunity in mice. PLoS One. 2013 Dec 17;8(12):e83274.
  55. Liang JG, JP Chen, Tan ZW, Peng J, Zheng X, Nishiura KJ, Ng J, Wang ZY, Wang DM, Chen Z* and Liu L*. Extracts of medicinal herb Sanguisorba officinalis inhibit the entry of human immunodeficiency virus type one. Journal of Food and Drug Analysis. 2013 Dec; 21(4):S52-S58.
  56. Chen Z* and Zhou J. Strengthening the role of dendritic cells in AIDS vaccine development. Journal of Antivirals & Antiretrovirals. 2013 Aug. 5: xxiii-xxiv. (Invited Editorial Article).
  57. Tan Z, Zhou J, Cheung AK, Yu Z, Cheung KW, Liang J, Wang H, Lee BK, Man K, Liu L, Yuen KY, Chen Z*. Vaccine-elicited CD8+ T cells cure mesothelioma by overcoming tumor-induced immunosuppressive environment. Cancer Research. 2014 Aug; 74:6010-21.
  58. Wu H, Zhang XM, Zhang HJ, Zhang, Q, Chen Z, Huang JD, Lee SS, Zheng BJ. In vitro selection of HIV-1 CRF08_BC variants resistant to reverse transcriptase inhibitors. AIDS Research and Human Retroviruses. 2015;31(2):260-70.
  59. Guo J, Zuo T, Cheng L, Wu X, Tang J, Sun C, Feng L, Chen L, Zhang L, Chen Z*. Simian immunodeficiency virus infection evades vaccine-elicited antibody responses to V2 region. Journal of Acquired Immune Deficiency Syndromes. 2015 Apr; 68(5):502-10.
  60. Liang J, Liu L, Cheung M, Lee MP, Wang H, Li CH, Chan CC, Nishiura K, Tang X, Tan Z, Peng J, Cheung KW, Yam WC, Chen Z*. Community-Based HIV-1 Early Diagnosis and Risk Behavior Analysis of Men Having Sex with Men in Hong Kong. PLoS One. 2015 Apr 27;10(4):e0125715.
  61. Zhang XM, Wu H, Zhang Q, Lau TC, Chu H, Chen Z, Jin DY, Zheng BJ. A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs. Journal of Antimicrobial Chemotherapy. 2015 May;70(5):1381-90.
  62. Zhang Y, Li SK, Yang YK, Liu M, Lee N, Tang X, Wang H, Liu L, Chen Z, Zhang C, Wang J, Kwok-Wing Tsui Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1. Scientific Reports. 2015 Jun 3;5:10806..
  63. Cheng L, Tang X, Liu L, Peng J, Nishiura K, Cheung AK, Guo J, Wu X, Tang HY, An M, Zhou J, Cheung KW, Wang H, Guan X, Wu Z, Chen Z*. Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis. MAbs 2015 July; 7(3): 620-9.
  64. Cong Z, Xue J, Xiong J, Yao N, Wang W, Jiang H, Chen T, Chen Z, Wei Q, Qin C. Correlation of central memory CD4+ T-Cell decrease in the peripheral blood with disease progression in SIVmac251-infected Chinese rhesus macaques. Journal of Medical Primatology 2015 Aug;44(4):175-82. doi: 10.1111/jmp.12171.
  65. Zhe Y, Tan Z, Lee BK, Tang J, Wu X, Cheung KW, Lo NTL, Man K, Liu L, Chen Z*. Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells. Oncotarget. 2015 Oct; 6(32): 32426-38.
  66. Lai KK, Cheung NN, Yang F, Dai J, Liu L, Chen Z, Sze KH, Chen H, Yuen KY, Kao RY. Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics. Journal of Virology. 2016;90(5):2690-701. doi:10.1128/JVI.02326-15
  67. Cheung KW, Peng Q, He L, Cai K, Jiang Q, Zhou B, To SW, Yam WC, Liu L, Chen Z*, Wang H. Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY® System. PLoS One. 2016 Apr; 11(4):e0153641.
  68. Tang J, Yam WC, Chen Z. Mycobacterium tuberculosis infection and vaccine development. Tuberculosis (Edinb). 2016 May;98:30-41.
  69. Liu L, Wei Q, Nishiura K, Peng J, Wang H, Midkiff C, Alvarez X, Qin C, Lackner A and Chen Z*. Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques. Mucosal Immunology. 2016 Jul; 9(4):1089-101.
  70. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F; International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen É, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nature Medicine. 2016 Aug;22(8):839-50.
  71. Ren H, Wang G, Wang S, Chen H, ChenZ, Hu H, Cheng G and Zhou P. Cross-protection of newly emerging HPAI H5 viruses by neutralizing human monoclonal antibodies: A viable alternative to oseltamivir. MAbs. 2016 Aug-Sep; 8(6): 1156–1166.
  72. Li MD, Hser YI, Chen Z, Chang L. Promoting Global Health – Prevention and Treatment of Substance Abuse and HIV in Asia. Journal of Neuroimmune Pharmacology. 2016 Sep;11(3):379-82.
  73. Wu X, Liu L, Cheung KW, Wang H, Lu X, Cheung AK, Liu W, Huang X, Li Y, Chen ZW, Chen SM, Zhang T, Wu H, Chen Z*..Brain Invasion by CD4(+) T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice. Journal of Neuroimmune Pharmacology. 2016 Sep; 11(3):572-83.
  74. Wei Q, Liu L, Cong Z, Wu X, Wang H, Qin C, Molina P, Chen Z*. Chronic Δ(9)-Tetrahydrocannabinol Administration Reduces IgE(+)B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin. Journal of Neuroimmune Pharmacology. 2016 Sep;11(3):584-591.
  75. Lau SK, Woo PC, Li KS, Zhang HJ, Fan RY, Zhang AJ, Chan BC, Lam CS, Yip CC, Yuen MC, Chan KH, Chen ZW, Yuen KY. Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model. PLoS Pathogens. 2016 Oct 13;12(10):e1005911.
  76. Liu L, Wang W, Matz J, Ye C, Bracq L, Delon J, Kimata JT, Chen Z, Benichou S, Zhou P. The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1. Journal of Virology. 2016 Nov 14;90(23):10642-10659.
  77. Cheung A.K., Huang Y., Kwok H.Y., Chen M., Chen Z*. Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells. Blood Advances. 2017 Jan; 1(5):306-318.
  78. Liu M, Zhou J, Chen Z, Cheng AS. Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy. The Journal of Pathology. 2017 Jan;241(1):10-24.
  79. Jiang W, Wang S, Chen H, Ren H, Huang X, Wang G, Chen Z, Chen L, Chen Z, Zhou P. A Bivalent Heterologous DNA Virus-Like-Particle Prime-Boost Vaccine Elicits Broad Protection against both Group 1 and 2 Influenza A Viruses. Journal of Virology. 2017 Apr 13;91(9). pii: e02052-16.
  80. To KKW, Chan WM, Li KSM, Lam CSF, Chen Z, Tse H, Lau SKP, Woo PCY, Yuen KY. High prevalence of four novel astrovirus genotype species identified from rodents in China. Journal of General Virology. 2017 May;98(5):1004-1015.
  81. Hser YI, Li MD, Grella C, Brecht L, Chen Z, Chang SL, Chang L, Normand J, Tai B. The 2017 CALDAR Summer Institute and International Conference Promoting Global Health-Precision Research in Substance Abuse, HIV, and Care. J Neuroimmune 2017    Jun;      12(Suppl          2):79-80.          doi: 10.1007/s11481-017-9750-9.PMID: 28497234
  82. Cheung AK, Kwok HY, Huang Y, Chen M, Mo Y, Wu X, Lam KS, Kong HK, Lau TCK, Zhou J, Li J, Cheng L, Lee BK, Peng Q, Lu X, An M, Wang H, Shang H, Zhou B, Wu H, Xu A, Yuen KY, Chen Z*. Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection. Nature Microbiology. 2017 Oct;2(10):1389-1402.
  83. Tang X, Guo J, Cheng L, Sun C, Liu L, Zuo T, Wang H, Chen L, Zhang L, Chen Z*. Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses. Vaccine. 2017 May 2;35(19):2582-2591.
  84. Wu X, Guo J, Niu M, An M, Liu L, Wang H, Jin X, Zhang Q, Lam KS, Wu T, Wang H, Wang Q, Du Y, Li J, Cheng L, Tang HY, Shang H, Zhang L, Zhou P, Chen Z*. Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. Journal of Clinical Investigation. 2018 Apr 23. pii: 96764.
  85. Zhou J, Liu M, Sun H, Feng Y, Xu L, Chan AWH, Tong JH, Wong J, Chong CCN, Lai PBS, Wang HK, Tsang SW, Goodwin T, Liu R, Huang L, Chen Z, Sung JJ, Chow KL, To KF, Cheng AS Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy. Gut. 2018 May;67(5):931-944.
  86. Liu W, Wong YC, Chen SMY, Tang J, Wang H, Cheung AKL, Chen Z*. DNA prime/MVTT boost regimen with HIV-1 mosaic Gag enhances the potency of antigen-specific immune responses. Vaccine. 2018 Jul 25;36(31):4621-4632.
  87. Wang S, Ren H, Jiang W, Chen H, Hu H, Chen Z, Zhou P. Divergent Requirement of Fc-Fcγ Receptor Interactions for In Vivo Protection against Influenza Viruses by Two Pan-H5 Hemagglutinin Antibodies. Journal of Virology 2017 May 12;91(11). pii: e02065-16.
  88. Gao N, Wang W, Wang C, Gu T, Guo R, Yu B, Kong W, Qin C, Giorgi EE, Chen Z, Townsley S, Hu SL, Yu X, Gao F, Development of broad neutralization activity in simian/human immunodeficiency virus-infected rhesus macaques after long-term infection. AIDS. 2018 Mar 13;32(5):555-563.
  89. Cheung KW, Wu T, Ho SF, Wong YC, Liu L, Wang H, Chen Z. α4β7 CD4 effector/effector memory T cells differentiate into productively and latently infected central memory T cells by transforming growth factor β1 during HIV-1 infection. Journal of Virology 2018 Mar 28;92(8). pii: e01510-17.
  90. Chen M, Jia MH, Ma YL, Luo HB, Chen HC, Yang CJ, Dai J, Yang L, Dong LJ, Lu R, Song LJ, Han Y, Lu JY, Cheung AKL, Chen Z, Lu L. The changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China. Epidemiology & Infection. 2018 Apr;146(6):775-781.
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  92. Tan Z, Liu L, Chiu MS, Cheung KW, Yan CW, Yu Z, Lee BK, Liu W, Man K, Chen Z*.Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression. Oncoimmunology. 2018 Oct 16;8(1):e1518672.
  1. Ling L, Tang X, Huang X, Li J, Wang H, Chen Z*. AAV-Vectored Fms-Related Tyrosine Kinase 3 Ligand Inhibits CD34+ Progenitor Cell Engraftment in Humanized Mice. Journal of Neuroimmune Pharmacology. 2018 Dec;13(4):541-550.
  2. Chen Z. Monkey Models and HIV Vaccine Research. Adv Exp Med Biol. 2018;1075:97-124. doi: 10.1007/978-981-13-0484-2_5.PMID: 30030791
  3. Tang J, Cai Y, Liang J, Tan Z, Tang X, Zhang C, Cheng L, Zhou J, Wang H, Yam WC, Chen X, Wang H, Chen Z*. In vivo electroporation of a codon-optimized BERopt DNA vaccine protects mice from pathogenic Mycobacterium tuberculosis aerosol challenge. Tuberculosis (Edinb). 2018 Dec;113:65-75.
  4. Cui H, Geng W, Sun H, Han X, An M, Jiang Y, Zhang Z, Chen Z, Xu J, Hu Q, Zhao B, Zhou B, Shang H. Rapid CD4+ T-cell decline is associated with coreceptor switch among MSM primarily infected with HIV-1 CRF01_AE in Northeast China. AIDS. 2019 Jan 27;33(1):13-22. doi: 10.1097/QAD.0000000000001981.PMID: 30102662
  5. Liu L, Wei Q, Lin Q, Fang J, Wang H, Kwok HY, Tang HY, Nishiura K, Peng J, Tan Z, Wu T, Cheung KW, Chan KH, Alvarez X, Qin C, Lackner A, Perlman S, Yuen KY, Chen Z*. Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection. Journal of Clinical Investigation Insight. 2019 Feb 21;4(4). pii: 123158.
  6. Ling L, Wu T, To KKW, Cheung KW, Lui KO, Niu M, Lam KS, Wang CC, Li J, Wang H, Yuen KY, Chen Z*. Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after cART interruption in humanized mice. AIDS. 2019 Jan 14.
  7. Cheng L, Tang X, Xu L, Zhang L, Shi H, Peng Q, Zhao F, Zhou Y, He Y, Wang H, Zhou B, Gao Z, Chen Z*. Interferon-γ upregulates Δ42PD1 expression on human monocytes via the PI3K/AKT pathway. Immunobiology. 2019 May;224(3):388-396.
  8. Cheung AKL, Huang Y, Chen M and Chen Z. Transfer of HIV-1 from HIV-1 latently infected CD34+ haematopoietic progenitors to CD4+ T cells. Hong Kong Med J. PMID: 31761770.
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  73. He X, Wong YC, Zhong M, Mo Y, Li B, Yim LY, Li X, Liu W, Du Y, Wang H, Zhang H, Chen Z*. A follow-up study: 6-year cART-free virologic control of rhesus macaques after PD-1-based DNA vaccination against pathogenic SHIVSF162P3CN challenge. Microbiology Spectrum. 2023 Dec 12;11(6):e0335023. doi: 10.1128/spectrum.03350-23. Epub 2023 Nov 3. PMID: 37921496; PMCID: PMC10715146.
  74. Tan Z, Chiu MS, Yue M, Kwok HY, Tse MH, Wen Y, Chen B, Yang D, Zhou D, Song YQ, Man K, Chen Z*. Enhancing the efficacy of vaccinia-based oncolytic virotherapy by inhibiting CXCR2-mediated MDSC trafficking. Journal of Leukocyte Biology. 2023 Dec 8:qiad150. doi: 10.1093/jleuko/qiad150.
  75. H Xu, M Yue, R Zhou, P Wang, MYC Wong, J Wang, H Huang, B Chen, Y Mo, R CY Tam, B Zhou, Z Du, H Huang, L Liu, Z Tan, KY Yuen, Y Song, H Chen, ZW Chen*. Lung resident memory CD8+ T cells derived from Central memory T cells prevent tumor lung metastasis. Cancer Review. (Under Review)

Book Chapters:

  1. Chen Z. SIV-specific DNA in Museum Specimens from Non-human Primates. New Mexico State University,
  2. Chen Z. Evolution and characterization of primate lentiviruses (SIVsm and HIV-2) in West Ph.D. Dissertation. New York University Publications, 1996.
  3. AIDS – Laboratory techniques and quality control. Chapter 3: Specific immune response against HIV-1 2009, Science Press, Beijing, People’s Republic of China.
  4. HIV Immunology. Chapter 6: HIV-1 Mucosal Immunity, Science Press, Beijing, People’s Republic of China, in
  5. HIV Manual 2013, Chapter One, Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region
  6. HIV Vaccines and Cure: The Path Towards Finding an Effective Cure and Chapter 5. Springer Nature Singapore Pte Ltd. 2018.
  7. HIV Manual 2019, Chapter One, Hong Kong, Publisher:

 

Oral Presentations with Conference Papers in International Meetings

  1. 12th Annual Symposium on Non-human Primate Models for AIDS, Oct 12-15, 1994; Boston, Massachusetts,
  2. 13th Annual Symposium on Non-human Primate Models for AIDS, 5-8, 1995; Monterey, California, USA.
  3. 14th Annual Symposium on Non-human Primate Models for AIDS, Oct.23-26, 1996; Portland, Oregon, USA (Late breaker, Identification of Rhesus CCR5 as entry co-receptor of diverse SIV).
  4. 4th Conference on Retroviruses and Opportunistic Infections, Jan. 22-26, 1997; Washington C., USA (Genetically Divergent Simian Immunodeficiency Viruses Use CCR5 but not CXCR4 as a Coreceptor for Entry)
  5. Symposium on HIV/AIDS Prevention and Care, May 20, 1997; Beijing,
  6. 15th Annual Symposium on Non-human Primate Models for AIDS, Sept. 3-6, 1997; Seattle, Washington,
  7. 16th Annual Symposium on Non-human Primate Models for AIDS, Oct. 3-6, 1998; Atlanta,
  8. 6th Conference on Retroviruses and Opportunistic Infections, Jan. 22-26, 1999; Chicago, USA (Natural Infection of a Red-Capped Mangabey with a Homozygous CCR5 Defect (d24) by a CCR2b-Tropic Simian Immunodeficiency Virus).
  9. 1st AIDS Symposium at Chung Shan Medical & Dental College, Feb. 25-26, 1999; Taichung,
  10. The Fifth International AIDS Conference at Taipei, 27-Mar. 1, 1999; Taipei, Taiwan.
  11. The Sixth International AIDS Conference at Chung Shan Medical & Dental College, Feb. 25-26, 2000; Taichung,
  12. The 2001 Workshop of Aaron Diamond AIDS Research Center, Emory Vaccine Center and UCLA AIDS Institute Collaborative Vaccine, June 26&27, 2001; Los Angeles, USA
  13. 19th Annual Symposium on Non-human Primate Models for AIDS, 7-10, 2001; San Juan, Puerto Rico.
  14. AIDS Vaccine Conference 2003, Sept. 18-23, Hilton New York, New York City, ,
  15. International meeting on emerging infectious disease and AIDS at Wuhan University, 16-17, 2004; P.R. China.
  16. Expert Group Meeting on HIV/AIDS in China, Aug. 26, 2005; Beijing, R. China, organized by CAMS/MOH.
  17. AIDS Vaccine Conference 2006, Aug 28-Sept. 2, 2006; RAI, Amsterdam, the Netherlands.
  18. 13th SNIP Annual Conference – Neuroimmune Circuits and Infectious Disease, April 10-14, 2007, Salt Lake City, Utah,
  19. International Conference on Modern Mucosal Vaccine, Adjuvants and Microbicides, Oct. 22-24, 2008, Porto,
  20. Scientific, regulatory and public health aspects of microbicide research and development, Nov 3-6, 2008, Nanjing, China. Organized by WHO and NJU. Chair of the plenary session 3.
  21. Second Ditan International Conference on Infectious Diseases. Nov 14-17, 2008, Beijing, China. Chair of the session for HIV/AIDS.
  22. 8th Asia-Pacific Congress of Medical Feb 25-28, 2009, Hong Kong, China.
  23. 15th Society on NeuroImmune Pharmacology Conference. Apr 21-24, 2009. Wuhan, China.
  24. Second Annual World Summit of Antivirals. Jul 18-20, 2009. Beijing, China.
  25. Third Ditan International Conference on Infectious Diseases. Jul 30 – Aug 2, 2009. Beijing, China.
  26. AIDS Vaccine 2009, Satellite meeting on replicating viral vaccine vectors; Oct 19-22, Paris, France.
  27. Frontiers in Biomedical Research HKU 2009. Dec 4, 2009. Hong Kong, China.
  28. 2010 Annual General Meeting and Scientific Meeting of Hong Kong Society for Immunology. Apr 17, 2010.   Hong Kong, China. Role: Keynote Speaker (“Control of a pathogenic SIVmac239 infection by a heterologous mucosal prime and intramuscular boost vaccination strategy”)
  29. Symposium on HIV ART updates, organized by Shenzhen Third People’s Hospital, Shenzhen, China April 24, 2010, Role: Keynote Speaker
  30. China AIDS Vaccine Initiative (CAVI) Executive Committee Meeting & The Second China AIDS Vaccine Forum. May 10-14, 2010. Shanghai, China. Role: Speaker
  31. Fourth Ditan International Conference on Infectious Diseases. Jul 15 – 18, Beijing, China.
  32. 1st World Congress of Virus and Infections 2010. July 31 – Aug 3, 2010. Busan, South Korea (SAB member and section Chairman).
  33. The 4th International Symposium on Emerging Viral Diseases. Oct 24-27, 2010. Wuhan, China.
  34. “Tsinghua-Yue-Yuen Symposium on Medical Sciences 2011”at Tsinghua University, April 12, 2011, titled of speech: “Novel mechanism of SARS-CoV transmission”
  35. CAVI Meeting, talk titled: “A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity”, September 17, 2011.
  36. Phacilitate Vaccine Forum Singapore, Talk Titled: “Induction of robust HIV-1 specific T cell immunity”, September 19-21, 2011 (invited Speaker and Panelist)
  37. “Forum of Frontier Virology”, Invited lecturer and oral presenter, Beijing, October 12, 2011. Chinese Academy of Sciences.
  38. Heterologous immunization induces potent anti-SIV immunity with qualitative and quantitative improvements. Immunology 2011 98th Annunal Meeting 186:53.22 Tang  X & Chen Z. (2011).
  39. 18th Society on NeuroImmune Pharmacology (SNIP) Conference in Honolulu, HI, invited to co-chair for the “Spice and Bath Salts – An Emerging Health Risk in the United States” Symposium (both Oral and Poster Presentation) Titled: “Infection of Chinese Macaques by a Neurotropic SIVmac251/CNS without and with Tetrahydrocannabinal (THC)” April 24-28, 2012.
  40. 2012 National Institute on Drug Abuse (NIDA) International forum – New and Emerging Psychoactive Substances: Second Interdisciplinary Forum, Palm Springs, USA, Abstract titled: “Tetrahydrocannabinal (THC) Effect on SIVmac251 Infection in Chinese Macaques”, Invited Lecturer and featured guest, June 8-13, 2012.
  41. College on Problems of Drug Dependence (CPDD) Workshop: Chinese and Global Health, Invited Speaker (Oral and Poster Presentation); June 12, 2012
  42. AIDS Vaccine Conference 2012, Boston, USA, September 9-12, 2012 (Oral and Poster Presentation).
  43. Frontiers in Biomedical Research HKU 2012. Dec 14, 2012.  Hong Kong, China.  Invited Speaker and Section Chair.
  44. International conference on Global Health: Prevention and Treatment of Substance Use Disorders and HIV in Taipei, Taiwan, talk titled: “Potentiating HIV-Specific CTL via Dendritic Cells” Invited Speaker, April 17-19, 2013.
  45. Invited speaker, Promoting global health—treatment and prevention of substance abuse and HIV in Asia, held in Taiwan in 2015.
  46. Invited speaker, Promoting global health—treatment and prevention of substance abuse and HIV in Asia, held in UCLA, USA in 2016.
  47. Invited speakers at The International Global Virus Network (GVN) Meeting hosted by The Peter Doherty Institute for Infection and  Immunity  in    September 25-27, 2017.
  48. Invited speaker, “A novel tandem bispecific neutralizing antibody for HIV-1 functional cure”, Xiangshan Meeting, 27 April 2018, Beijing
  49. Invited speaker, “Humanized NSG Mouse Models for HIV/AIDS”, Nanjing 26 September 2018.
  50. Invited speaker, HIV Research for Prevention (HIVR4P) 2018, the only global scientific conference focused exclusively on the challenging and fast-growing field of biomedical HIV prevention research, Oct. 21-25, 2018 at Madrid Marriott Auditorium, Madrid, Spain.
  51. Invited speaker, The 5th AIDS Forum of Beijing, Hong Kong, Macau and Taiwan, on “HIV Immunotherapy”, 12 April 2019, Taipei.

Invited Lectures and Speaker for Seminars at Universities and Institutes

  1. Institute of Microbiology, Chinese Academy of Sciences, China, 2000.
  2. School of Life Science and Engineering, Tsinghua University, China, 2001.
  3. The Chinese University of Hong Kong, Dept of Chemistry, China, 2001.
  4. College of Life Sciences, Wuhan University, China, 2001.
  5. College of Life Sciences, Wuhan University, China, 2002.
  6. College of Life Sciences, Beijing University, China, 2002.
  7. Section of Microbial Pathogenesis, Yale University School of Medicine, USA, 2003.
  8. Center for Public Health Research, Nanjing University, China, 2004.
  9. Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2007.
  10. Louisiana State University Health Sciences Center, USA, 2007.
  11. Tulane Regional Primate Research Laboratory, USA, 2007.
  12. Pearl River Delta AIDS Vaccine Forum, Guangzhou, Oct 12-13, 2007.
  13. HIV/AIDS Research Conference, Oct 13-19, 2007, Beijing.
  14. Forum on AIDS and Hepatitis vaccines; organized by the Chinese Academy of Sciences, Beijing, Nov 29, 2007.
  15. International conference on AIDS vaccine preparedness; co-organized by International AIDS Vaccine Initiative and the Chinese Academy of Medical Sciences, Guangxi, Dec 3-5, 2007.
  16. “HIV/AIDS: Unanswered Questions” at Queen Elizabeth Hospital, July 25, 2008, Hong Kong.
  17. “中國科學院 2008 年傳染病學術交流會” organized by the Chinese Academy of Sciences, Guangzhou, Jan 3-5, 2008.
  18. Global Health Lessons through the Lens of HIV/AIDS, Beijing, Nov 11, 2008. Co Organized by Ministry of Health of China and Harvard University.
  19. CAMS-IAVI HIV/AIDS Vaccine Workshop; “為愛滋病疫苗創建最佳社會配套環境研 討 會 ” co-organized by International AIDS Vaccine Initiative and the Chinese Academy of Medical Sciences, Beijing, Nov 18-19, 2008.
  20. Yunnan CDC 7th Anniversary Conference and Director Meeting, organized by Yunnan CDC, Kunming, Dec 16-19, 2008.
  21. The first scientific forum on AIDS; “第一届愛滋病科學論壇”, organized by the Chinese CDC, Beijing, Dec 22, 2008.
  22. Cross Strait Workshop on Emerging Infectious Diseases, Xiamen, Sept 17-20, 2009, China.
  23. CAVI-IAVI 2009 AIDS Vaccine  Network Meeting,  Nov.  9-10, 2009, Beijing.      (CAVI: Chinese AIDS Vaccine Initiative; IAVI: International AIDS Vaccine Initiative).
  24. 愛滋病專題學術研討會 organized by Institut Pasteur of Shanghai, Chinese Academy of Sciences, Mar 19, 2010, Shanghai.
  25. Invited Speaker 深圳巿繼續教育學習班《2010 深圳巿愛滋病篩查實驗室品質考評工作培訓班》, organized by Shenzhen CDC, Shenzhen, China, May 27, 2010.
  26. 深圳巿繼續教育學習班《愛滋病抗病毒治療的新進展》organized by Shenzhen Third People’s Hospital, April 24, 2010, Shenzhen, China.
  27. Institut of Pasteur Shanghai, Chinese Academy of  Sciences, May 10, 2010. Shanghai, China.
  28. “The fifth China Health communication Conference and Tsinghua public health science conference” at Tsinghua University in Beijing, Nov 4-5, 2010.
  29. “Tsinghua-Yue-Yuen Symposium on Medical Sciences 2011” at Tsinghua University, April 12, 2011, titled of speech: “解密沙士(SARS)病毒传播的新机制”.
  30. “Canossian Global Youth Conference” July 18, 2011, Hong Kong.
  31. Invited Seminar at the Department of Biomedical Sciences, UNT Health Science Center, Fort Worth, Texas; Seminar titled: “Antigen targeting to DCs by soluble PD-1 amplifies HIV-1 Gag CD8+ T-cell immunity” June 13-16, 2012. USA.
  32. NIDA Neuroscience Consortium Cutting-edge seminar series, symposium entitled “HIV/NeuroAIDS Treatment and Prevention beyong HAART – Thinking Outside the Box”. Talk titled: “Vaccine: A Possible Solution to Protect against HIV/NeuroAIDS”. (Invited Speaker/Expert), June 18, 2012. NIH, USA.
  33. Invited lecture, Hong Kong AIDS Foundation for hundreds of local community people on our PD1-based vaccine in 2013.
  34. Invited speaker, “艾滋病疫苗与免疫根治研究”, 廣州, 5 Janury 2015.
  35. Invited speaker, “Biomedical Prevention and Possible Cure of HIV/AIDS”, Hospital Authority Convention, 19 May 2015, Hong Kong.
  36. Invited speaker at The Aaron Diamond AIDS Research Center, The Rockefeller University, USA. July 2015.
  37. Invited seminar speaker at the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, USA. July 2015.
  38. A talk entitled “PD1-based vaccines for AIDS and cancer immunotherapy” at Institut Pasteur, Paris, France. October 2015.
  39. Invited seminar speaker, “Immunology and Cancer Research”, 4 March 2016, CUHK.
  40. Invited speaker, A potent bi-specific bnAb for HIV prevention and immunotherapy. Tianjin, 17 Nov 15 2016.
  41. Invited seminar speaker, “Antibody Engineering for HIV Prevention and Immunotherapeutic Cure”, The 78th Academic Seminar on Biomedicine and Biotechnology. 1 December 2016, Chinese Academy of Science.
  42. Invited lectures at world-leading research institutions and universities to exchange our findings on PD1-based vaccine including (1) US National Institute of Health for The Neuroscience Consortium Cutting Edge Symposium, (2) The Ragon Institute of MGH, MIT and Harvard, (3) The Aaron Diamond AIDS Research Center of Rockefeller University, and (4) Institut Pasteur in Paris.
  43. Invited speaker, 中华医学会第七次全国艾滋病、病毒性丙型肝炎暨全国热带病学术会议 2015 年 9 月 18 日深圳.
  44. Invited speaker, 粤港澳大湾区合作发展座谈会, 12 May 2018, HKU.
  45. Invited speaker, 国家卫生健康委员会代表团座谈会 2018 年 5 月 8 日, 国家新发传染病重点实验室.
  46. Invited speaker, “登峰计划” 高峰论坛之 —— 肿瘤多学科研究新策略 ,香港大学深圳医院,香港大学外科系 , 2018 年 12 月 14 日地点:香港大学深圳医院学术会议中心.
  47. Invited speaker, Croucher Foundation Sponsored Conference 2018/2019, Gut Microbiome as a Biomarker and Therapy for Cancer Immunotherapy, 26 April 2019.
  48. Invited speaker, HIV or not, does it make a difference under COVID-19? September 16, 2021, Cheung Kung Hai Conference Centre, William MW Mong Block, 21 Sassoon Road.
  49. Invited speaker, The 40th Anniversary of HIV Discovery. November 30, 2021 Guangdong-HongKong Greater Bay Area AIDS Prevention and Control Seminar (Webinar)
  50. Invited Speaker for Webinar: Advances in COVID Management Vaccines/ Treatment and Technologies. March 18, 2022 Organized by Society For Innovative Healthcare Hong Kong.
  51. Invited Speaker for Webinar: 2022 愛滋病專防冶专家高層對話 August 21, 2022, Organized by 廣東省性病愛滋病防冶協會
  52. Invited Speaker, Recent Advances in HIV Cure Research, 2nd Symposium on Combating Infectious Diseases, December 16, 2022, Lecture Theatre 2, G/F, William MW Mong Block, 21 Sassoon Road

Teaching duties performed at HKU

Graduate research students supervised

(Please include only students in respect of whom you are the principal supervisor)

  • Number of research students supervised

 

Graduated

Current

PhD

Full-time

21

10

Part-time

 

 

MPhil

Full-time

1

 

Part-time

 

 

 

  • For graduated research students

 

Degree

Mode

Holder of Hong Kong PhD Fellowship Scheme

(Y/N)

Immediate

Latest

Contact email

Name

(MPhil /

of

Appointment after

appointment

address and/or phone

 

PhD)

Study

graduation

 

number

 

 

(F/T /

 

 

 

 

 

P/T)

 

 

 

Lu Xiaofan

PhD

F/T

N

Research Associate;

Associate

luxiaofan2008hk@cc

 

 

 

 

Beijing Key Lab for

professor;

mu.edu.cn

 

 

 

 

HIV/AIDS Beijing

Beijing Key Lab

 

 

 

 

 

You’An Hospital,

for HIV/AIDS

 

 

 

 

 

Capital Medical

Beijing You’An

 

 

 

 

 

University

Hospital, Capital

 

 

 

 

 

 

Medical

 

 

 

 

 

 

University

 

Kang Yuanxi

PhD

F/T

N

Postdoctoral Fellow, Stanford University, United States

NA

NA

Tang Xian

PhD

F/T

N

Research assistant,

Associate

Tel:

 

 

 

 

Institute of Live

professor,

(86)755-61222333-5

 

 

 

 

Disease, Shenzhen

Institute of Live

809

 

 

 

 

Third People’s

Disease,

E‐mail:

 

 

 

 

Hospital, Shenzhen,

Shenzhen Third

xtang0217@gmail.co

 

 

 

 

China.

People’s

m

 

 

 

 

 

Hospital,

 

 

 

 

 

 

Shenzhen,

 

 

 

 

 

 

China.

 

Zhou Jingying

PhD

F/T

N

Postdoctoral Fellow,

Tenue-track

Tel: 852-39439843

 

 

 

 

SBS, CUHK

Assistant

E-mail:

 

 

 

 

 

Professor; SBS,

zhoujy@cuhk.edu.hk

 

 

 

 

 

Lee Woo Sing

 

 

 

 

 

 

College, The

 

 

 

 

 

 

Chinese

 

 

 

 

 

 

University of

 

 

 

 

 

 

Hong Kong,

 

 

 

 

 

 

CUHK

 

Guo Jia

PhD

F/T

Y

Research Assistant;

Senior Research

Tel: +44 (0)20

 

 

 

 

AIDS Institute and

Associate;

33155986; Email:

 

 

 

 

Department of

Centre for

jia.guo@imperial.ac.

 

 

 

 

Microbiology, HKU

Immunology and

uk

 

 

 

 

 

Vaccinology,

 

 

 

 

 

 

Department of

 

 

 

 

 

 

Infectious

 

 

 

 

 

 

Disease,

 

 

 

 

 

 

Imperial College

 

 

 

 

 

 

London

 

Tan Zhiwu

PhD

F/T

N

Post-doctoral Fellow. AIDS Institute and Department of Microbiology, HKU

 

Research Assistant Professor, AIDS Institute and Department of Microbiology,

HKU

zwtan@hku.hk

Tang Jiansong

PhD

F/T

N

Product Manager: China Bioengineering Technology Group limited

Technical Director; Precision Health Research Center Co. Lt.

Tel: +852 92317133

Email:tjswhdx638@ 126.com

Peng Jie

PhD

F/T

N

Research Assistant; AIDS Institute and

Department of Microbiology, HKU

R&D Director; Shenzhen Pando

Medical Laboratory

sobinsonpj19@hotm ail.com

Wu Xilin

PhD

F/T

N

Research Associate; Medical school at Nanjing University

Associate Professor; Medical School at Nanjing University

Email: xilinwu@nju.edu.cn Tel:

+86-18805158739

Lee Boon Kiat

PhD

F/T

N

Technical Officer; Faculty Core Facility, Faculty of Medicine, HKU

Research Scientist, SPH Biotherapeutics (HK) Limited

lbk.hk@hotmail.com

 

+852 54416625

Chen MY Samantha

PhD

F/T

N

Postdoctoral Research Fellow; Ragon Institute of MGH, MIT and Harvard University

Senior Postdoctoral Research Fellow; University of Colorado Anschutz

Medical Campus

samueamu813@hot mail.com

Liu Wan

PhD

F/T

N

Postdoctoral Fellow; HKU

R&D Director: Shenzhen Ying He Yuan Medical Technology Development

Co. Ltd

458603680@qq.com

Lam Ka Shing

PhD

F/T

N

HKU MBBS student

HKU         MBBS

student

kslamab@connect.hk u.hk

Lin Qingqing

PhD

F/T

N

Research Associate; Shenzhen Innovation Immunotechnology Co.Ltd

same

dxdyleye@163.com

Ling Lijun

PhD

F/T

N

Postdoctoral fellow at University of North Carolina at

Chapel Hill

same

lijun100@ad.unc.edu

;

lijun100@connect.hk u.hk

Niu Mengyue

PhD

F/T

Y

Chief          Executive

Officer; Beijing Trinokure Technology Co., Ltd

same

mengyueniu@gmail. com

Huang Haode

MPhil

F/T

N

Research Assistant; AIDS Institute and Department             of

Microbiology, HKU

same

a311541x@gmail.co m

Zhou Dongyan

PhD

F/T

N

Postdoctoral fellow at CVVT of InnoHK

same

dongyanzhou@cvvt. hk

Mo Yufei

PhD

F/T

N

Postdoctoral fellow at AIDS Institute and Department             of Microbiology, HKU

same

mophie@hku.hk

Li Shuang

PhD

F/T

N

RD Engineer, Sinovac                                   Life Sciences Co. Ltd

same

Lshuang1996@gmail

.com

Yang Qing

PhD

F/T

N

Analyst,  黄埔生物

医药产业投资基金

same

ethanyeng@outlook. com

Zhou Biao

PhD

F/T

N

Research Scientist, SPH Biotherapeutics (HK) Limited

same

zhoubiao2018@gmai l.com

Yee Ming

PhD

F/T

N

 

same

 

Chen Ruijun

PhD

F/T

N

 

same

 

Huang Huarong

PhD

F/T

N

Postdoctoral fellow at CVVT of InnoHK

same

hhuarong@connect.hku.hk

Xu Haoran

PhD

F/T

N

 

same

haoran_Xu@connect.hku.hk

Liu Wenjing

PhD

F/T

N

 

same

liuwan@sibs.ac.cn

 

 

 

 

 

 

 

Curriculum Committee and Innovation

1.             Committee member for HKU Postgraduate Student Presidential PhD Scholar Programme, invited by graduate school dean

2.             Review committee member for HKU AOE/TRS grant applications (2019 – present)

3.             Elected Member for Faculty High Degree Committee, 2016 – 2019

4.             Organizing Committee Member for the Bachelor of Biomedical Sciences in 2011, appointed by the faculty dean

5.             Curriculum Committee Member for the Bachelor of Biomedical Sciences, 2011- present

6.             Admission Committee Member: Conduct review and Interview for JUPAS and Non-JUPAS for the Bachelor of Biomedical Sciences, 2011 – Present

7.             Year 3 Course Coordinator for the Bachelor of Biomedical Sciences, 2011 – Present

8.             Chief Course Coordinator and Teacher for “Infection and Immunity” of the Bachelor of Biomedical Sciences program, 2011 – Present

9.             Co-director of organizing a course on HIV/AIDS for graduate students in Hong Kong and surrounding regions (mainly Asian countries)

 

Teaching Performed at HKU

1.  2007/08 Second semester; Course title: Pasteur-Asia Virology Course; Course code: MMPH 6171; Credit: 3; Duration: 3 weeks / 30 contact hours per week.

2.  2008/09 Fall semester; Course title: 1st Pasteur-Asia Immunology Course

3.  Workshop on “HIV/AIDS after 25 Years of Research” to HKU staff and students, February 22, 2008

4.  Plenary Lecture on “HIV/AIDS Research: Challenges and Opportunities” at the HKU Summer Science Institute 2008, Faculty of Science, July 23, 2008

5.  Lecture on “Stop AIDS. Keep the Promise.” to HKU staff and students, December 1, 2009

6.  2009/10 Second semester; Course title: Haematology and Immunology; Course code: MBBS2004; Credit: 3; Duration: 5 weeks / 4 contact hours per week

7.  2010/11 First semester; Course title: Central Nerve System; Course code: MBBS2006; Credit: 3; Duration: 5 weeks / 4 contact hours per week

8.  2010/11 Second semester; Course title: Haematology and Immunology Course code: MBBS2004; Credit: 3; Duration: 5 weeks / 4 contact hours per week

9.  2010/11 Second semester; Tutorials for common core course; Course title: Infectious disease in a changing world; Course code: CCST9008; Credit: 3; Duration: 4 weeks/ 2 contact hours per week

10. 2010/11 Summer semester; Tutorials for independent student, Mr. Koon Yin NG; Course code: MBBS II; Course Name: Self-Initiated SSM; Duration: 29 days

11. November 24, 2011: 4th HKU Pasteur Immunology Course, talk titled: “HIV Vaccine Development” (Invited Lecturer)

12. 2011/12 First semester; Course title: Central Nerve System; Course code: MBBSII; Credit: 3; Duration: 5 weeks / 4 contact hours per week

13. 2011/12 Second semester; Tutorials for common core course; Course title: Haematology and Immunology; Course code: MBBS2004, Credit 3, Duration: 5 weeks/4 contact hours per week

14. 2011/12 Second semester: Tutorials for common core course; Course title: Infectious disease in a changing world; Course code: CCST9008: Credit 3; Duration: 4 weeks/2 contact hours per week (2 tutorials – Group 5 and Group 6)

15. November 2012, organized the event “Hong Kong Symposium on HIV/AIDS 2012”. This Symposium provided a timely response to the record number of HIV infections in Hong Kong recently. Over 200 people attended, among them scientists, physicians, nurses, students, government officers and AIDS activists from various non-government organizations in Hong Kong and Mainland China.

16. December 14, 2012 “Frontiers in Biomedical Research, HKU, invited to give a talk under the “Infection and Immunology” session. This event is one  of  the  highlighted scientific events of the Faculty’s 125th Anniversary.

17. 2012/13 First semester; Course title: Central Nerve System; Course code: MBBS2006; Credit: 3, Duration: 5 weeks/4 contact hours per week

18. 2012/13 Second semester; Course title: Haematology and Immunology; Course code: MBBS2004; Credit: 3; Duration: 5 weeks/4 contact hours per week

19. 2012/13 Second semester; Tutorials for common core course; Course title: Infectious disease in a changing world; Course code: CCST9008, Credit: 3, Duration: 4 weeks/ 2 contact hours per week (2 tutorials, T5 and T7)

20. 2012/13 Serve as the Faculty Academic Advisor and Mentor for ten first-year students of the MBBS.

21. Jul 14-26, 2013, 10th HKU-Pasteur Virology Course on HIV/AIDS. Talk titled “Vaccine Strategies”. Role: Co-director and Lecturer, with 23 speakers and 28 students from 11 countries.

22. 2013/14 First semester; Course title: Central Nerve System; Course code: MBBS2006; Credit: 3, Duration: 5 weeks/4 contact hours per week

23. 2013/14 Second semester; Course title: Haematology  and  Immunology;  Course code: MBBS2004; Credit: 3; Duration: 5 weeks/4 contact hours per week

24. 2014/15 MMedSc Specialized  Module:  MMPH6176/PATH6200  Current Topics and Techniques in Immunology

25. 2014/15 Second semester; Course Coordinator: BBMS3005 Infection and Immunity

26. 2014/15 First semester; Course title: Central Nerve System; Course code: MBBS2006; Credit: 3, Duration: 5 weeks/4 contact hours per week

27. 2014/15 Second semester; Course title: Haematology  and  Immunology;  Course code: MBBS2004; Credit: 3; Duration: 5 weeks/4 contact hours per week

28. 2015/16 Second semester; Course Coordinator: BBMS3005 Infection and Immunity

29. 2015/16 First semester; Course title: Central Nerve System; Course code: MBBS3007; Credit: 3, Duration: 5 weeks/4 contact hours per week

30. 2015/16 Second semester; Course title: Haematology  and  Immunology;  Course code: MBBS3009; Credit: 3; Duration: 5 weeks/4 contact hours per week

31. 2015/16 First semester; Course title: Vaccination and immunotherapy; Course code: BBMS3001

32. 2016/17 Second semester; Course Coordinator: BBMS3005 Infection and Immunity

33. 2016/17 First semester; Course title: Central Nerve System; Course code: MBBS3007; Credit: 3, Duration: 5 weeks/4 contact hours per week

34. 2016/17 Second semester; Course title: Haematology and Immunology; Course code: MBBS3009; Credit: 3; Duration: 5 weeks/4 contact hours per week

35. 2016/17 Second semester; Course title: Cardiopulmonary & Renal Systems Block; Course code: MBBS; Credit: 3; Duration: 5 weeks/4 contact hours per week

36. 2016/17 First semester; Course title: HIV pandemic: History, Problems and the Future; Course code: BBMS3010

37. 2016/17 MPH Course; Course title: Emerging Infectious Diseases; Course code: CMED 6104

38. 2016/17 Graduate Course; Course title: Current Topics and Techniques in Immunology; Course code: MMPH6176

39. 2017/18 First semester; Course title: Central Nerve System; Course code: MBBS3007; Credit: 3, Duration: 5 weeks/4 contact hours per week

40. 2017/18 Second semester; Course title: Cardiopulmonary and Rental Systems; Course code: MBBS3007; Credit: 3, Duration: 5 weeks/4 contact hours per week

41. 2017/18 First semester; Course title: Vaccination and immunotherapy; Course code: BBMS3001

42. 2017/18 First semester; Course title: HIV pandemic: History, Problems and the Future; Course code: BBMS3010

43. 2017/18 MPH Course; Course title: Emerging Infectious Diseases; Course code: CMED 6104

44. 2017/18 Graduate Course; Course title: Current Topics and Techniques in Immunology; Course code: MMPH6176

45. 2017/18 Second semester; Course Coordinator: BBMS3005 Infection and Immunity

46. 2017/18 Tutors for the Health Research Project (HRP); Total teaching hours: 16

47. 2018/19 First semester; Course title: Gastrointestinal System; Credit: 3, Duration: 5 weeks/4 contact hours per week

48. 2018/19 First semester; Course title: Clinical Foundation; Duration: 2 weeks/3 contact hours per week

49. 2018/19 First semester; Course title: Cardiopulmonary and Rental Systems; Course code: MBBS3007; Credit: 3, Duration: 5 weeks/4 contact hours per week

50. 2018/19 First semester; Course title: Vaccination and immunotherapy; Course code: BBMS3001

51. 2018/19 First semester; Course title: Host-parasite relationship; Course code: BBMS3001

52. 2018/19 First semester; Course title: HIV pandemic: History, Problems and the Future; Course code: BBMS3010

53. 2018/19 Second semester; Course Coordinator: BBMS3005 Infection and Immunity

54. 2018/19 MMedSc Specialized Course; Course title: Current Topics and Techniques in Immunology; Course code: MMPH6176/PATH6202

55. 2019/20 First semester; Course title: Gastrointestinal System; Course code: MBBS2011; Credit: 3, Duration: 5 weeks/4 contact hours per week

56. 2019/20 First semester; Course title: Vaccination and immunotherapy; Course code: BBMS3001

57. 2019/20 First semester; Course title: Host-parasite relationship; Course code: BBMS3001

58. 2019/20 First semester; Course title: HIV pandemic: History, Problems and the Future; Course code: BBMS3010

59. 2019/20 Second semester; Course Coordinator: BBMS3005 Infection and Immunity MMedSc Specialized Course; Course title: Current Topics and Techniques in Immunology; Course code: MMPH6176/PATH6202

60. 2020/2021 First semester; Course title: Gastrointestinal System; Course code: MBBS2011; Credit: 3, Duration: 5 weeks/4 contact hours per week

61. 2020/21 First semester; Course title: Vaccination and immunotherapy; Course code: BBMS3001

62. 2020/21 First semester; Course title: Host-parasite relationship; Course code: BBMS3001

63. 2020/21 First semester; Course title: HIV pandemic: History, Problems and the Future; Course code: BBMS3010

64. 2020/21 Second semester; Course Coordinator: BBMS3005 Infection and Immunity MMedSc Specialized Course; Course title: Current Topics and Techniques in Immunology; Course code: MMPH6176/PATH6202

65. 2021/22 First semester; Course title: Gastrointestinal System; Course code: MBBS2011; Credit: 3, Duration: 5 weeks/4 contact hours per week

66. 2021/22 First semester; Course title: Vaccination and immunotherapy; Course code: BBMS3001

67. 2021/22 First semester; Course title: Host-parasite relationship; Course code: BBMS3001

68. 2021/22 First semester; Course title: HIV pandemic: History, Problems and the Future; Course code: BBMS3010

69. 2021/22 Second semester; Course Coordinator: BBMS3005 Infection and Immunity

70. 2021/22 MMedSc Specialized Course; Course title: Current Topics and Techniques in Immunology; Course code: MMPH6176/PATH6202

71. 2022/23 First semester; Course title: Vaccination and immunotherapy; Course code: BBMS3001

72. 2022/23 First semester; Course title: Host-parasite relationship; Course code: BBMS3001

73. 2022/23 First semester; Course title: HIV pandemic: History, Problems and the Future; Course code: BBMS3010

 

Visiting Scientists Trained at HKU

1.      Xu Yao, MD, 2009; Fuzhou CDC, China (one first-author paper in JAIDS)

2.      Zhiying Liu, Ph.D. 2010. Beijing You-An Hospital, China (one first-author paper in Epidemiol. Infect.)

3.      Qiaoli Peng, MD, 2011; Shenzhen’s 3rd Hospital, China (one first-author paper in JAIDS)

4.      Lin Cheng, Ph.D. 2012; Nanjing University, Nanjing, China; PhD awarded, (one first-author paper in mAb)

5.      Minghui An, MD. 2013; Chinese Medical University, Shenyang, China, (one co-author paper in JCI)

 

Postdocs Trained at HKU

1.      Susan X. Zhao, M.D, 1997-2001; Research Associate; 2001-2005 Harvard Medical School, Boston, MA M.D.; 2005-2008 Massachusetts General Hospital, Boston, MA. Intern Internal Medicine and Resident Internal Medicine; 2008-2012, University of California, San Francisco, CA, Fellow, Cardiology.

2.      Lin Yang, Postdoc, 2005; postdoc at the University of Pittsburgh, U.S.A.; current post: Associate professor at Wuhan Institute of Virology, Chinese 
Academy of Sciences.

3.      Li Liu, Postdoc., 2007; current post: research assistant professor at AIDS Institute of the University of Hong Kong

4.      Qing Fang, Ph.D., 2007; current post: postdoc at the Aaron Diamond AIDS Research Center, The Rockefeller University, U.S.A.

5.      Henggui Liu, Ph.D., 2011; current post: PI at Harbin Veterinary Research Institute, Chinese Academy of Agricultural Science, China.

6.      Haibo Wang, Ph.D. 2010; current post: Vice-director, Zhuhai Customs

7.      Dr Ka Wai Cheung, Ph.D. 2011; current post: Senior Research Scientist, Singapore

8.      Dr Allen Ka Loon Cheung, Ph.D. 2011; current post: Assistant Professor, BU, HK

9.      Dr Zhe YU, Ph.D. 2013; Mentorship of the Xiang-Jiang Scholar Program, current post: Associate Professor, Tangdu Hospital, Xian, China

10.  Dr Tan Zhiwu, Ph.D. 2014; Current post: Research Assistant Professor, AIDS Institute of the University of Hong Kong

11.  Dr Yick Chun Wong, Ph.D. 2016; AIDS Institute of the University of Hong Kong; Current post: Scientific Director at Immuno Cure HK LTD.

12.  Dr Zhou Runhong, Ph.D. 2018; AIDS Institute of the University of Hong Kong; Current post: Research Assistant Professor, same place.

13.  Dr Lok Yan Yam, Ph.D. 2018; AIDS Institute of the University of Hong Kong; current post: Scientific Officer at Hong Kong Hospital Authority

14.  Dr Cao Tianyu, Ph.D. 2019; AIDS Institute of the University of Hong Kong; current post: Associate Professor, Tangdu Hospital, Xian, China

15.  Dr. Chee-Hoo Yip, Ph.D. 2020; Postdoctoral fellow, AIDS Institute of the University of Hong Kong

 

Postdocs being trained at HKU

1.    Dr. Yufei Mo, Ph.D. 2021; Postdoctoral fellow, AIDS Institute of the University of Hong Kong

2.    Dr, Wang Weiwei, Ph.D. 2023; Postdoctoral fellow, AIDS Institute of the University of Hong Kong

 

Professional Services at HKU and Local Communities

 

1.  Director, AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong; July 2007 – present.

2.  Chairman, Hong Kong Society for Immunology; Term: 2018 – 2020.

3.  Co-director and guest professor, HKU-AIDS Institute Shenzhen Research Laboratory, The Third People Hospital of Shenzhen, 2011-present.

4.  Council Member, Hong Kong Society for Immunology; Term: 2010 – present.

5.  Board director, Hong Kong AIDS Foundation, Hong Kong SAR; Term: 2019 – present.

6.  Board member, Friends of Hope Education Fund, Hong Kong SAR; 2008 – present; Initiated the AIDS orphan educational program.

7.  Board director, AIDS Concerns, Hong Kong SAR; Term: 2012 – 2016

8.  Executive Committee Member of China AIDS Vaccine Initiative: 2008 – present.

9.  Expert Committee Member of China AIDS Vaccine Network (www.cavax.org): 2008 – present.

10.  Scientific Advisory Board Member, Key Immunology Laboratory of Ministry of Health on HIV/AIDS, 2011-present.

11.  Scientific Advisory Board Member, Guangdong Provincial Key Laboratory of Emerging Infectious Diseases, 2013-present.

12.  Scientific Advisory Board Member, Shenzhen CDC, 2013-present.

13.  Teaching and give talk on AIDS to Hong Kong local community, invited by Dr. Kwok Siu Ming.

14.  Providing HIV/AIDS training for volunteers of Hong Kong AIDS Foundation chaired by Dr. CH Leong for several years.

15.  Recommended HIV/AIDS Strategies for Hong Kong (2017-2021)

16.  Recommended HIV/AIDS Strategies for Hong Kong (2012-2016)

17.  The Medicine Annual Quiz 2017, Hong Kong

18.  Journey of HIV Medicine at Hong Kong Museum of Medical Sciences in 2017

 

Eight Symposiums on HIV/AIDS and Immunology: as the Chairman and a Speaker

1        Grand Challenge on HIV Cure and Vaccine, 1 December 2017, co-organized with Tsinghua University; Venue: Cheung Kung Hai Lecture Theatre 4, 21 Sassoon Road, HKU LKS Faculty of Medicine

2        Hong Kong Immunology Forum 2016, 10 September 2016, Venue: Lecture Theater 1, G/F, Cheung Kung Hai Conference Centre, William MW Mong Block, 21 Sassoon Road, Hong Kong

3        Hong Kong Immunology Forum 2015, 5 August 2015, Venue: Lecture Theater 1, G/F, Cheung Kung Hai Conference Centre, William MW Mong Block, 21 Sassoon Road, Hong Kong

4        HIV/AIDS FORUM 2014, 22-23 November 2014, Venue: Lecture Theater 1, G/F, Cheung Kung Hai Conference Centre, William MW Mong Block, 21 Sassoon Road, Hong Kong

5        INTERNATIONAL SYMPOSIUM ON HIV/AIDS 2013, Date: 17-18 December 2013, Venue: Shenzhen third People`s Hospital

6        Hong Kong Symposium on HIV/AIDS 2012: exploring new ways for HIV prevention, 13 November, 2012; co-organized with ACA chaired by Dr. Susan Fan; Venue: Cheung Kung Hai Lecture Theatre 1, 21 Sassoon Road, HKU LKS Faculty of Medicine

7        Hong Kong Symposium on Equal Opportunity of HIV/AIDS Care, 14 November, 2012, co-organized with Hong Kong AIDS Foundation chaired by Dr. CH Leong; Time: Nov 14, 1-6 pm; Venue: Cheung Kung Hai Lecture Theatre 1, 21 Sassoon Road, HKU LKS Faculty of Medicine

8        Inaugural symposium on “HIV/AIDS in China: Challenges and Opportunities”, 22 November, 2007, Venue: Lecture Theater 1, G/F, Cheung Kung Hai Conference Centre, William MW Mong Block, 21 Sassoon Road, Hong Kong

 

Three Croucher Courses on Advances in Immunology: as Co-organizer and a Speaker

1.      2018 A tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice

2.      2016 A chimeric bi-specific neutralizing antibody for HIV prevention and immunotherapy

3.      2014 Potential of Vaccine-elicited CD8+ T Cells in Curing HIV-Infection and Cancer

 

Eight Public Lectures: as a Chairman/Co-organizer in Hong Kong

1.      HLA-E revisited, June 2, 2017, by Professor Sir Andrew McMichael, Professor, Fellow of the Royal Society and of the Academy of Medical Sciences.

2.      Is There An HIV Myeloid Reservoir? Yes, No, Maybe, September 7, 2015, by Professor Ronald Swanstrom, Charles Postelle Distinguished Professor of Biochemistry, Director, UNC Center for AIDS Research, University of North Carolina, Chapel Hill, U.S.A.

3.      Challenges of HIV / AIDS Prevention, Care and Treatment in the 21st Century, co-organized with Hong Kong Advisory council on AIDS; Lecture Theatre 1, Cheung Kung Hai Conference Centre, 21 Sassoon Road by Nobel Laureate Professor Françoise BARRE-SINOUSSI, Institut Pasteur, France
(Recipient of the Nobel Prize in Physiology or Medicine in 2008); 24 July 2013

4.      Challenges of HIV/AIDS at the Bench, in the Clinic, and from the Field (Joint Lecture Co-Organized by the ITC, CUHK, and HKU), April 28, 2011, Speaker: Professor David D Ho, Scientific Director and Chief Executive Officer, Aaron Diamond AIDS Research Center, Rockefeller University, USA

5.      HIV/AIDS – a Scientific and Human Adventure in Response to an Emerging Epidemic. Venue: Rayson Huang Theatre, The University of Hong Kong, Pokfulam Road; Nobel Laureate Professor Françoise Barré-Sinoussi delivers the second Centenary Distinguished Lecture as part of HKU’s 100th anniversary celebrations in 2011-2012. 22 Nov 2010.

6.      The AIDS Epidemic and Prospects for Control co-organized with  Hong Kong Advisory council on AIDS, 20th Anniversary Public lecture by Professor David Ho, Scientific Director and Chief Executive Officer, Aaron Diamond AIDS Research Center, Rockefeller University, USA; 18 June 2010.

7.      The Global Threat of HIV/AIDS: How Does Science Face the Challenge. Lecture Theatre 2-4, Cheung Kung Hai Conference Centre.
Speaker: Professor Jay A Levy 
University of California, San Francisco, USA. 4 Dec 2009.

8.      Threats Posed by the AIDS Pandemic. December 4, 2008
Time: 11:00 a.m.

– 12:30 p.m.
Venue: Rayson Huang Theatre, The University of Hong Kong, Pokfulam Road; 
Speaker: Professor David D Ho, Scientific Director and Chief Executive Officer, Aaron Diamond AIDS Research Center, Rockefeller University, USA.

 

Postgraduate Committee Members (External / Internal examiner)

1.      Sun Caijun, Ph.D., Chinese Academy of Sciences, Chairman of Ph.D. Defense Committee, 2009

2.      Qin Kun, Ph.D., Department of Microbiology, University of Hong Kong, Examiner, Ph.D. Defense Committee, 2010

3.      Jean Millet, University of Hong Kong-Pasteur Center, Examiner, Ph.D. Defense Committee, 2010

4.      Hong Yao, Ph.D., Department of Chemistry, Faculty of Science, University of Hong Kong, Examiner, Ph.D. Defense Committee, 2010

5.      Jian Zheng, Oral examination (PhD student of Dr. Wenwei Tu) Served as internal examiner.

6.      Wu Hao, Oral examination (student of JD Huang) Served as internal examiner.

7.      Cheung Chun LAM Oral Examination (student of Dr. Honglin Chen) Served as internal examiner.

8.      Nancy Hiu Lan Leung, Oral Examination (MPhil student of Dr. Roberto Bruzzone, Pasteur) Served as internal examiner. Department of Microbiology, University of Hong Kong, Examiner, Defense Committee, 2011.

9.      Daniel Chu Viva Examination (PhD student of Prof. Malik Peiris) Served as internal examiner.

10.  Huailiang Ma Viva Examination (PhD student of Dr. Leo Poon, School of Public Health and Dr. Beatrice Nal from Brunel University) Served as the Chairperson of the Thesis Examining Committee for this student from HKU-Pasteur Research Centre

11.  Diana Dik Yan Wong, (MPhil student of Prof. JSM Peiris, School of Public Health) Served as the Chairperson of the Thesis Examining Committee.

12.  Peter Pak-Hang CHEUNG Oral Examination (PhD student of Prof. Malik Peiris, School of Public Health) Served as internal examiner.

13.  Isabelle Dutry, Viva exam, (PhD student of Prof. JSM Peiris, School of Public Health) Served as Internal Examiner.

14.  Karen, Kin Yi AU, (PhD student of Prof. Allen Lau, Department of Paediatrics & Adolescent Medicine) Served as Internal Examiner

15.  Chung Lam Cheung, Ph.D., Department of Microbiology, University of Hong Kong, Examiner, Ph.D. Defense Committee, 2011

16.  Jian Zheng, Ph.D., (PhD student of Prof. YL Lau and Dr. WW Tu, Department of Pediatrics & Adolescent Medicine, University of Hong Kong, Examiner, Ph.D. Defense Committee, 2011

17.  Chu Ka Wing, Ph.D. Department of Microbiology, University of Hong Kong, Examiner, Ph.D. Defense Committee, 2012

18.  Shi Lei, Ph.D., (PhD student of Dr. Jiandong Huang, Department of Biochemistry), Oral defense, served as Internal Examiner, 2012

19.  Bo Pan, PhD (PhD student of Dr Quan Hao, Department of Physiology), Oral defense, served as Chairman, 2013

20.  Teng Ooiean, PhD (PhD student of Dr HL Yen, School of Public Health), served as Internal Examiner, 2014

21.  Pong Chi Him, PhD (PhD student of Prof YL Lau, Department of Paediatrics & Adolescent Medicine), served as Internal Examiner, 2014

22.  Deng Jun, PhD (PhD student of Prof LW Lu, Department of Pathology), served as Internal Examiner, 2014

23.  Leung Ho Chuen, PhD (PhD student of Prof BJ Zheng, Department of Microbiology), served as Internal Examiner, 2014

24.  To Wai Chi Sabrina, PhD (PhD student of Dr WC Yam, Department of Microbiology), served as Internal Examiner, 2014

25.  Wang Xiaohui, PhD (PhD student of Prof LW Lu, Department of Pathology), served as Internal Examiner, 2014

26.  Zhang Xiaomin, PhD (PhD student of Prof DY Jin, Department of Biochemistry), served as Internal Examiner, 2015

27.  Xiang Zheng, PhD (PhD student of Prof WW Tu, Department of Paediatrics & Adolescent Medicine), served as Internal Examiner, 2015

28.  Lin Qiubin, PhD (PhD student of Prof JD Huang, School of Biomedical Sciences), served as Internal Examiner, 2015

29.  Ma Chi, PhD (PhD student of Prof Y Guan, School of Biomedical Sciences), served as Internal Examiner, 2015

30.  Dirkzwager Roderick Marshall, PhD (PhD student of Dr Julian A Tanner, School of Biomedical Sciences), served as Internal Examiner, 2015

31.  Jiao Delong, PhD (PhD student of Prof CK Wong, Department of Chemical Pathology, CUHK), served as External Examiner, 2015

32.  Yujuan Chai, PhD (Supervisor: Prof Y Guan, School of Public Health), served as Internal Examiner, 2016

33.  Xiaofeng Huang, PhD (Supervisor: Prof HL Chen, Department of Microbiology), served as Internal Examiner, 2016

34.  Ada Yim, PhD (Supervisor: Dr Vera Chan, Department of Medicine), served as Internal Examiner, 2016

35.  Louisa Chan, PhD (Supervisor: Dr Michael CW Chan, School of Public Health), served as Internal Examiner, 2016

36.  Tsang Chi Ching, PhD (Supervisor: Prof HL Chen, Department of Microbiology), served as Internal Examiner, 2016

37.  Hu Menglong, PhD (Supervisor: Prof Q Hao, School of Biomedical Sciences), served as Internal Examiner, 2016

38.  Nj Ke, PhD (Supervisor: Prof WW Tu, Department of Paediatrics and Adolescent Medicine), served as Internal Examiner, 2017

39.  Chan Fuk Woo, MD (Supervisor: Prof KY Yuen, Department of Microbiology), served as Internal Examiner, 2017

40.  Lee Hok Yeung, PhD (Supervisor: Prof R Bruzzone, School of Public Health), served as Chairperson, 2017

41.  Jin Ziying, PhD (Supervisor: Dr HC Zhu, School of Public Health), served as Chairperson, 2017

42.  Park Min Ah, PhD (Supervisor: Dr TK Wu, School of Public Health), served as Chairperson, 2018

43.  Mak Chun Kit, PhD (Supervisor: Prof JSM Peiris, School of Public Health), served as Internal Examiner, 2018

44.  Ou Zhihua, PhD (Supervisor: Prof Y Guan, School of Public Health), served as Chairperson, 2018

45.  Li Hung Sing, PhD (Supervisor: Dr CW Chan, School of Public Health), served as Chairperson, 2018

46.  Zhu Jing, PhD (Supervisor: Prof CK Wong, Department of Chemical Pathology, CUHK), served as External Examiner, 2018

47.  Kuok Iok Teng, PhD (Supervisor: Dr CW Chan, School of Public Health), served as Chairperson, 2018

48.  An Liwei, PhD (Supervisor: Dr Michael SY Huen, School of Biomedical Sciences), served as Chairperson, 2018

49.  Chen Miao, PhD (Supervisor: Prof XY Guan, Department of Clinical Oncology), served as Internal Examiner, 2018

50.  Li Jiatao, PhD (Supervisor: Dr Kathy OL Lui, Department of Chemical Pathology, CUHK), served as External Examiner, 2019

51.  LI Wanfei, PhD (Supervisor: Prof Zhang Hongjie, School of Chinese Medicine, HK Baptist University), served as External Examiner, 2019

52.  LIU Xiaoyu, PhD (Supervisor: Prof. CHENG Sze Lok Alfred; School of Biomedical Sciences, CUHK), served as External Examiner, 2020

53.  ZHAI Jianning, PhD (Supervisor: Prof. Jun YU, Department of Medicine & Therapeutics, CUHK), served as External Examiner, 2020

54.  Kishore Krishna KUMAREE, PhD (Supervisor: Prof. Guan Yi, School of Public Health), served as Chairperson, 2020

55.  SO Tak Yuk Ray, PhD (Supervisor: Professor Malik Peiris, School of Public Health), served as Internal Examiner, 2021

56.  YANG Xinxiang, PhD (Supervisor: Prof Kwan MAN, Department of Surgery), served as Internal Examiner, 2021

57.  Yu Zhang, PhD (Supervisor: Prof Xin-yuan Guan, Department of Clinical Oncology), served as Internal Examiner, 2021

58.  Deng Chong, PhD (Supervisor: Prof LW LU, Department of Pathology), served as Internal Examiner, 2021

59.  HUANG Chunyu, PhD (Supervisor: Tu Wenwei, Department of Paediatrics and Adolescent Medicine), served as Internal Examiner, 2021

60.  TSANG Nga Yi, PhD (Supervisor: Prof Zhang Hongjie, School of Chinese Medicine, HK Baptist University), served as External Examiner, 2021

61.  Fan Zhuming, PhD (Supervisor: Prof Hao Quan, School of Biomedical Sciences), served as Chairperson, 2022

62.  ZHU Jiye, PhD (Supervisor: Dr TT Cheung, Department of Surgery), served as Internal Examiner, 2022

63.  Mr LYU Huibin, PhD (Supervisor: Prof Roberto Bruzzone, School of Public Health), served as Internal Examiner, 2022

64.  LU Jiahuan, PhD (Supervisor: Prof KF To; Department of Anatomical and Cellular Pathology, CUHK), served as External Examiner, 2022

65.  WANG Jing, PhD (Prof. CHENG Sze Lok Alfred; School of Biomedical Sciences, CUHK), served as External Examiner, 2022